Acute dietary nitrate does not reduce resting metabolic rate or oxidative stress marker 8-isoprostane in healthy males and females

Carriker, Colin R.; Harrison, Caleb; Bockover, Evan J.; Ratcliffe, Brycen J.; Crowe, Sierra; Morales-Acuña, Francisco; Gurovich, Alvaro N.

doi:10.1080/09637486.2019.1580683

Cited by 4 publications

(3 citation statements)

References 40 publications

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“…An increased dietary nitrate intake induced upregulation of catalase, superoxide dismutase, glutathione peroxidase, mitofusin 2 and PGC1α in PBMCs in patients with metabolic syndrome [ 99 ]. Nevertheless, no significant effects of dietary nitrate supplementation were found on markers of oxidative stress (i.e., malondialdehyde, mitochondrial superoxide, 8-isoprostane) in other studies [ 100 – 102 ], which clearly emphasizes the need for further basic and translational research in this area.…”

Section: Introductionmentioning

confidence: 79%

Does dietary nitrate boost the effects of caloric restriction on brain health? Potential physiological mechanisms and implications for future research

Alharbi,

Stephan,

Shannon

et al. 2023

Nutr Metab (Lond)

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Dementia is a highly prevalent and costly disease characterised by deterioration of cognitive and physical capacity due to changes in brain function and structure. Given the absence of effective treatment options for dementia, dietary and other lifestyle approaches have been advocated as potential strategies to reduce the burden of this condition. Maintaining an optimal nutritional status is vital for the preservation of brain function and structure. Several studies have recognised the significant role of nutritional factors to protect and enhance metabolic, cerebrovascular, and neurocognitive functions. Caloric restriction (CR) positively impacts on brain function via a modulation of mitochondrial efficiency, endothelial function, neuro-inflammatory, antioxidant and autophagy responses. Dietary nitrate, which serves as a substrate for the ubiquitous gasotransmitter nitric oxide (NO), has been identified as a promising nutritional intervention that could have an important role in improving vascular and metabolic brain regulation by affecting oxidative metabolism, ROS production, and endothelial and neuronal integrity. Only one study has recently tested the combined effects of both interventions and showed preliminary, positive outcomes cognitive function. This paper explores the potential synergistic effects of a nutritional strategy based on the co-administration of CR and a high-nitrate diet as a potential and more effective (than either intervention alone) strategy to protect brain health and reduce dementia risk.

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Section: Introductionmentioning

confidence: 79%

Does dietary nitrate boost the effects of caloric restriction on brain health? Potential physiological mechanisms and implications for future research

Alharbi,

Stephan,

Shannon

et al. 2023

Nutr Metab (Lond)

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“…The macroscopic effect of these mechanisms was tested in a 3-day dietary nitrate supplementation trial showing a reduction of REE by 4.2% (−82 kcal/day) measured by indirect calorimetry in healthy subjects [ 52 ]. However, these initial findings have not been replicated in subsequent studies of different duration (i.e., 2 h or 7 days) as no significant changes were found for REE after nitrate supplementation [ 53 , 54 ]. All these studies were conducted in energy balance whereas our study purposively investigated whether dietary nitrate may amplify the expected (i.e., due to the decrease in metabolically active tissue) reduction in REE post-weight loss induced by CR.…”

Section: Discussionmentioning

confidence: 97%

Caloric Restriction (CR) Plus High-Nitrate Beetroot Juice Does Not Amplify CR-Induced Metabolic Adaptation and Improves Vascular and Cognitive Functions in Overweight Adults: A 14-Day Pilot Randomised Trial

et al. 2023

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Caloric restriction (CR) and dietary nitrate supplementation are nutritional interventions with pleiotropic physiological functions. This pilot study investigates the combined effects of CR and nitrate-rich beetroot juice (BRJ) on metabolic, vascular, and cognitive functions in overweight and obese middle-aged and older adults. This was a two-arm, parallel randomized clinical trial including 29 participants allocated to CR + BRJ (n = 15) or CR alone (n = 14) for 14 days. Body composition, resting energy expenditure (REE), and hand-grip strength were measured. Resting blood pressure (BP) and microvascular endothelial function were measured, and Trail-Making Test A and B were used to assess cognitive function. Salivary nitrate and nitrite, and urinary nitrate and 8-isoprostane concentrations were measured. Changes in body composition, REE, and systolic and diastolic BP were similar between the two interventions (p > 0.05). The CR + BRJ intervention produced greater changes in average microvascular flux (p = 0.03), NO-dependent endothelial activity (p = 0.02), and TMT-B cognitive scores (p = 0.012) compared to CR alone. Changes in urinary 8-isoprostane were greater in the CR + BRJ group (p = 0.02), and they were inversely associated with changes in average microvascular flux (r = −0.53, p = 0.003). These preliminary findings suggest that greater effects on vascular and cognitive functions could be achieved by combining CR with dietary nitrate supplementation.

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“…Alternatively, rather than increasing NO production per se the rich concentration of polyphenols and other antioxidants in BRJ (37) could act in concert with any NO that is produced, either by prolonging NO bioavailability and/or by protecting cellular machinery from other reactive nitrogen and/or oxygen species. However, numerous studies to date have failed to reveal any influence of either acute or repeated BRJ intake on markers of oxidative stress in various populations (38)(39)(40)(41)(42)(43). For example, we recently determined the effects of daily ingestion of either NO 3 − -containing or NO 3 − -free BRJ for 2 wk on plasma 8-hydroxydeoxyguanosine (8-OHdG), protein carbonyls (PCs), and 4-hydroxynonenal (4-HNE), markers of oxidative damage to DNA/RNA, proteins/amino acids, and lipids, respectively, in 65-79 y old men and women (43).…”

Section: Discussionmentioning

confidence: 99%

Beetroot juice supplementation and exercise performance: is there more to the story than just nitrate?

Zoughaib,

Fry,

Singhal

et al. 2024

Front. Nutr.

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This mini-review summarizes the comparative effects of different sources of dietary nitrate (NO3−), beetroot juice (BRJ) and nitrate salts (NIT), on physiological function and exercise capacity. Our objectives were to determine whether BRJ is superior to NIT in enhancing exercise-related outcomes, and to explore the potential contribution of other putatively beneficial compounds in BRJ beyond NO3−. We conducted a comparative analysis of recent studies focused on the impact of BRJ versus NIT on submaximal oxygen consumption (VO2), endurance performance, adaptations to training, and recovery from muscle-damaging exercise. While both NO3− sources provide benefits, there is some evidence that BRJ may offer additional advantages, specifically in reducing VO2 during high-intensity exercise, magnifying performance improvements with training, and improving recovery post-exercise. These reported differences could be due to the hypothesized antioxidant and/or anti-inflammatory properties of BRJ resulting from the rich spectrum of phytonutrients it contains. However, significant limitations to published studies directly comparing BRJ and NIT make it quite challenging to draw any firm conclusions. We provide recommendations to help guide further research into the important question of whether there is more to the story of BRJ than just NO3−.

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Acute dietary nitrate does not reduce resting metabolic rate or oxidative stress marker 8-isoprostane in healthy males and females

Cited by 4 publications

References 40 publications

Does dietary nitrate boost the effects of caloric restriction on brain health? Potential physiological mechanisms and implications for future research

Does dietary nitrate boost the effects of caloric restriction on brain health? Potential physiological mechanisms and implications for future research

Caloric Restriction (CR) Plus High-Nitrate Beetroot Juice Does Not Amplify CR-Induced Metabolic Adaptation and Improves Vascular and Cognitive Functions in Overweight Adults: A 14-Day Pilot Randomised Trial

Beetroot juice supplementation and exercise performance: is there more to the story than just nitrate?

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