Acute development of multiple keratoacanthomas and squamous cell carcinomas after treatment with infliximab

Esser, Adam C.; Abril, Andy; Fayne, Scott; Doyle, John A.

doi:10.1016/j.jaad.2003.11.044

Cited by 75 publications

(39 citation statements)

References 15 publications

(11 reference statements)

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“…Definite associations were demonstrated for infusion/injection site reactions, whereas psoriasis and psoriasiform lesions, lupuslike syndromes, vasculitis, and cutaneous infections were found to be strongly associated with anti-TNF agents. A moderate association was apparent between anti-TNF treatment and eczematous reactions, lichenoid reactions, and granulomatous diseases, RCT 22,139 Case reports [131][132][133] whereas cutaneous lymphomas, non-melanoma skin cancers, and melanoma, mainly described in case reports, were poorly linked to anti-TNF treatment.…”

Section: Resultsmentioning

confidence: 99%

Cutaneous side effects of anti–tumor necrosis factor biologic therapy: A clinical review

Moustou

Matekovits

Dessinioti

et al. 2009

Journal of the American Academy of Dermatology

169

108

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Section: Resultsmentioning

confidence: 99%

Cutaneous side effects of anti–tumor necrosis factor biologic therapy: A clinical review

Moustou

Matekovits

Dessinioti

et al. 2009

Journal of the American Academy of Dermatology

169

108

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“…One patient with pre-existing photodamage of the skin developed multiple kerato-acanthomas and squamous cell carcinomas after infliximab treatment [35]. Several etanercept-treated patients developed a rapid onset of squamous cell carcinomas after treatment initiation [36, 37].…”

Section: Tnf-α Metabolic Pathway: Infliximab Etanercept and Adalimumabmentioning

confidence: 99%

Cutaneous Adverse Events of Biological Therapy for Psoriasis: Review of the Literature

Thielen¹,

Kuenzli²,

Saurat³

2005

Dermatology

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The use of biological agents is expanding worldwide as a new treatment alternative for chronic inflammatory diseases including more recently skin diseases, especially psoriasis. Although frequently observed, the knowledge about acute and chronic dermatological adverse events is limited, and potential pathogenic mechanisms still have to be identified. Exact diagnosis is required considering that dermatological adverse events raise a decisional challenge about potential treatment discontinuation. The object of this publication is to present an overview of the dermatological adverse events of these new treatment alternatives.

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“…However, the use of this agent has been reported to be associated with skin tumors. Esser et al [8] has reported a case of acute development of multiple keratoacanthomas and squamous cell carcinoma in a patient after treatment with infliximab.…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular Carcinoma Occurring in a Patient with Crohn’s Disease Treated with Both Azathioprine and Infliximab

et al. 2006

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Hepatocellular carcinoma is known to be associated with underlying liver diseases, such as cirrhosis, hemochromatosis, and chronic viral hepatitis. All reported cases of hepatocellular carcinoma in association with Crohn's disease involve patients treated previously with azathioprine or both azathioprine and steroids. However, hepatocellular carcinoma associated with the use of azathioprine and infliximab has not been reported. In this report, we describe an unusual case of hepatocellular carcinoma and focal hepatic glycogenosis (FHG) occurring in a non-cirrhotic Crohn's disease patient who has been treated with both azathioprine and infliximab.

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Acute development of multiple keratoacanthomas and squamous cell carcinomas after treatment with infliximab

Cited by 75 publications

References 15 publications

Cutaneous side effects of anti–tumor necrosis factor biologic therapy: A clinical review

Cutaneous side effects of anti–tumor necrosis factor biologic therapy: A clinical review

Cutaneous Adverse Events of Biological Therapy for Psoriasis: Review of the Literature

Hepatocellular Carcinoma Occurring in a Patient with Crohn’s Disease Treated with Both Azathioprine and Infliximab

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