Acute dermatomyositis-polymyositis and malignancy

Talbott, John H.

doi:10.1016/0049-0172(77)90033-6

Cited by 57 publications

(7 citation statements)

References 57 publications

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“…The concurrence of dermatomyositis and malignancy was first reported in 1916 [1], and has been the subject of numerous re ports [2][3][4]. The precise incidence of this as sociation remains controversial, owing to varying criteria used to diagnose dermato myositis.…”

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confidence: 99%

Dermatomyositis Associated with Chronic Myelogenous Leukemia

1985

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Dermatomyositis and polymyositis have been well established in association with malignant neoplastic disease. Most commonly, this association has been noted in patients with solid tumors rather than in patients with neoplasms of hematopoietic origin. We describe here a patient with chronic myelogenous leukemia who developed typical dermatomyositis, which responded to therapy with corticosteroids. This concurrence has been reported in only one previous patient to our knowledge. The nature and implications of the association of dermatomyositis and neoplasia are discussed.

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confidence: 99%

Dermatomyositis Associated with Chronic Myelogenous Leukemia

1985

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“…The rapid onset and evolution of the disease in this patient is relatively unusual and, despite his response to corticosteroid therapy, permanent impairment of muscle power subsequently ensued. Although some authors have suggested that patients with dermatomyositis and malignancy are less responsive to corticosteroids, many patients have been found to benefit from the initial administration of high doses of prednisolone, a significant improvement persisting after the dose is gradually reduced (Talbott 1977), as in this patient.…”

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confidence: 69%

Acute Dermatomyositis Associated with Squamous Carcinoma of the Oesophagus

Karp

1985

J R Soc Med

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The case of a patient with dermatomyositis and squamous carcinoma of the oesophagus is reported. No previous individual case report in English of this association has been traced. The patient responded to high-dose steroid therapy. The importance of differentiating dysphagia due to malignancy from that due to dermatomyositis is discussed.Case report A 63-year-old advertising consultant presented in July 1983 with a three-month history of epigastric discomfort after meals, abdominal bloating, intermittent regurgitation of food and the loss of one stone (6.3 kg) in weight. He had a past medical history of hypertension and had suffered a transient ischaemic attack 7 months previously when he was noted to have early clubbing. He was taking atenolol and aspirin, was a pipe smoker and consumed moderate quantities of alcohol. Physical examination now revealed marked clubbing and he was also noted to have palmar erythema. Routine blood investigations were normal. An upper gastrointestinal endoscopy revealed an extensive, ulcerating polypoidal carcinoma of the oesophagus extending 25-35 cm from the incisor teeth. The endoscope could not be passed distally. Biopsies showed this to be a poorly differentiated squamous cell carcinoma.Following a small haematemesis he received a split course of radiotherapy, with an initial 3000 cGy being administered in 8 fractions over two weeks and the same dose again six weeks later. He tolerated this very well, with considerable improvement in his swallowing and weight gain. Three weeks after completion of his radiotherapy he suddenly developed pain and weakness in his proximal limb muscles, a generalized itchy desquamating skin rash and lethargy. These symptoms rapidly progressed and he was admitted to hospital three weeks later.Examination revealed marked finger clubbing and a florid magenta-coloured scaly eruption on his face including both upper eyelids, the nape of his neck, elbows, forearms, dorsal hands, interphalangeal joints and dorsal proximal phalanges. There was nail-fold telangiectasia and slight scarring of the fingers, particularly both little fingers.

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“…Regression of Kaposi's sarcoma after discontinuation of immunosuppressive treatment is a hall mark ( 16). Howe ver, the present patient was unable to have p red nisone decreased beyond 20 mg orally every other day because of reac· tivation of the derma tomyosit is.…”

Section: Discussionmentioning

confidence: 95%

Dermatomyositis with Kaposi’s Sarcoma in a Patient without Human Immunodeficiency Virus-1 Infection

Liang

Szilagyi

Billick

et al. 1991

Canadian Journal of Gastroenterology

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myositis with Kaposi's sarcoma in a patient without human immunodeficiency virus-1 infection. Can J Gastroenterol 1991;5(1):l-4. The first case of dermatomyosit is complicating cutaneous and visceral Kaposi's sarcoma is presented in a 75-year-old man without human immunodeficiency virus infection. Dermacomyositis preceded a definitive diagnosis of Kaposi's sarcoma by six months, although in retrospect unrecognized lesions may have presented simultaneously. He was treated with prednisone and azathioprine, thus raising the possibility of the role of immunosuppression in promoting progress ion of the sarcoma. le is suggested that although the association between dermatomyosicis and Kaposi's sarcoma occurs rarely, dennatomyositis should be considered a paraneoplastic syndrome of Kaposi's sarcoma. Further, the finding of cutaneous les ions of Kaposi's sa rcoma co uld pred ict gastrointestinal involvement when dermatomyositis and Kaposi's sarcoma occur in the same patient Key Words: Dennatomyositis , Kaposi's sarcoma Dermatomyosite associee a un sarcome de Kaposi chez un patient non infecte par le virus d'immunodeficience humaine 1 RESUME: O n presence un cas de dcrmatomyosite compliquant un sa rcome de Kaposi (SK) cuta ne et visceral chez un homme de 75 ans qui n 'etait pas in fecte par le VIH. La dermatomyosite a precede le diagnostic fennel du SK de six mois, bien qu'en re trospective des lesions meconnues aie nt p u se manifest er simultanement. Le patient a ere traitc par la prednisone et l'azathioprine, ce qui evoque la possibilite du role de l'immunosuppression comme agent favorisant !'evolution du sarcome. On suggere que, bien que !'association dermatomyosite et sarcome de Kaposi soit ra re, la dennatomyosice soit consideree comme syndrome paraneoplasique d'un sa rcome de Kaposi. Plus encore, la decouverte des lesions cutanees du SK pourrait evoquer une atteinte gastrointestinale quand la dermatomyosite et le sarcome de Kaposi se declarent c hez un meme patient.

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Acute dermatomyositis-polymyositis and malignancy

Cited by 57 publications

References 57 publications

Dermatomyositis Associated with Chronic Myelogenous Leukemia

Dermatomyositis Associated with Chronic Myelogenous Leukemia

Acute Dermatomyositis Associated with Squamous Carcinoma of the Oesophagus

Dermatomyositis with Kaposi’s Sarcoma in a Patient without Human Immunodeficiency Virus-1 Infection

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