Acute COVID-19 Infection in a Pediatric Patient with ROHHAD

Udrea, Daniel S.; Lopez, Merrick; Avesar, Michael; Qureshi, Sonea; Moretti, A; Abd-Allah, Shamel; Chandnani, Harsha

doi:10.1055/s-0040-1718874

Cited by 4 publications

(3 citation statements)

References 12 publications

(13 reference statements)

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“…After screening by title and abstract, 246 articles proceeded to full-text review. Following full-text review, 126 articles, which reported on a total of 48,332 patients, were included for data extraction and analysis 25–148. The PRIMSA flow diagram is provided in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Coagulation Abnormalities and Clinical Complications in Children With SARS-CoV-2: A Systematic Review of 48,322 Patients

McDaniel

Commander²,

DeLaura

et al. 2021

Journal of Pediatric Hematology/Oncology

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Given the limited information on the coagulation abnormalities of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pediatric patients, we designed a systematic review to evaluate this topic. A comprehensive literature search was conducted for “SARS-CoV-2,” “coagulopathy,” and “pediatrics.” Two authors independently screened the articles that the search returned for bleeding, thrombosis, anticoagulant and/or antiplatelet usage, and abnormal laboratory markers in pediatric patients with SARS-CoV-2, and the authors then extracted the relevant data. One hundred twenty-six publications were included. Thirty-four (27%) studies reported thrombotic complications in 504 patients. Thirty-one (25%) studies reported bleeding complications in 410 patients. Ninety-eight (78%) studies reported abnormal laboratory values in 6580 patients. Finally, 56 (44%) studies reported anticoagulant and/or antiplatelet usage in 3124 patients. The variety of laboratory abnormalities and coagulation complications associated with SARS-CoV-2 presented in this review highlights the complexity and variability of the disease presentation in infants and children.

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Section: Resultsmentioning

confidence: 99%

Coagulation Abnormalities and Clinical Complications in Children With SARS-CoV-2: A Systematic Review of 48,322 Patients

McDaniel

Commander²,

DeLaura

et al. 2021

Journal of Pediatric Hematology/Oncology

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“…A total of 21 papers describe the regulation of contact between infants and mothers who are infected with COVID-19 or at risk of COVID-19. The types of interventions recommended by previous authors include avoiding skin-to-skin contact [ 56 , 138 – 142 ], isolation of infants in negative pressure incubators [ 60 , 67 , 111 , 143 , 144 ] or isolation separately from the mother for 14 days [ 55 , 77 , 111 , 120 , 138 , 140 ], rooming-in provision [ 61 , 68 , 147 ], and wear a face mask when breastfeeding or in close contact with infants [ 55 – 59 , 62 , 143 ].…”

Section: Discussionmentioning

confidence: 99%

Nursing care recommendation for pediatric COVID-19 patients in the hospital setting: A brief scoping review

Efendi

Natalia²,

Utami

et al. 2022

PLoS ONE

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Background The hospitalization of children during the COVID-19 pandemic has affected their physical and mental health. Pediatric nurses have faced challenges in providing high-quality nursing care for children and their families. However, the pediatric nursing care recommendations for COVID-19 patients in the hospital setting remain unclear. The current scoping review provides recommendations for nursing interventions for pediatric COVID-19 patients in the hospital setting. Methods and findings The selected articles containing management and nursing recommendations for COVID-19 that have occurred in pediatric patients ages 0–19 years old. A search strategy was developed and implemented in seven databases. We included peer-reviewed articles that reported observational or interventional studies, as well as policy papers, guides or guidelines, letters and editorials, and web articles. A total of 134 articles and other documents relevant to this review were included. We categorized the results based on The Nursing Intervention Classification (NIC) taxonomy which consists of six domains (e.g., Physiological: Basic); eleven classes (e.g., Nutrition Support); and eighteen intervention themes (e.g., Positioning, Family Presence Facilitation, Family Support, and Discharge Planning). Conclusion Apart from the intervention of physical problems, there is a need to promote patient- and family-centered care, play therapy, and discharge planning to help children and families cope with their new situation.

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“…He was not suitable for extracorporeal therapies due to hemodynamic instability and died ten days later in the intensive care unit. Udrea et al [4] described the first case of COVID-19 infection in a pediatric patient with ROHHAD. Our case is the first described adult case of ROHHAD syndrome presenting with COVID-19 infection.…”

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confidence: 99%

COVID-19 infection in a rare disease: ROHHAD syndrome

Çevik¹

2021

South Clin Ist Euras

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Letter to the EditorTo the Editor, Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) is an extremely rare disease having a high risk of mortality. Death usually occurs around the age of 10, but very few patients can survive beyond this age. [1,2] During the novel coronavirus (COVID-19) outbreak, the specific risks for patients with genetic disorders were not fully disclosed; however, available data indicated that they have a more severe course of infection compared to the general population requiring intensive care support. [3] We described the critical care management of a 20-year-old patient with ROHHAD syndrome presenting with COVID-19 and discussed the clinical challenges. The patient was admitted to the emergency department with complaints of shortness of breath and fever. His previous history revealed ROHHAD syndrome associated with intellectual delay, severe obstructive sleep apnea requiring continuous positive airway pressure, autonomic nervous system, and endocrine abnormalities. His computed tomography of the thorax demonstrated bilateral ground-glass infiltrates and pulmonary congestion. Laboratory investigations showed leucopenia (1.5x10 3 /uL), hypernatremia (169 mmol/L), impairment of renal and hepatic function (creatinine: 1.85 mg/dl, blood urea: 84mg/dl, alanine aminotransferase: 65 U/L, aspartate aminotransferase: 110 U/L, international normalized ratio: 1.82 and prothrombin time: 23.7 sec), elevated level of D-dimer (2690 µgr/L), ferritin (63.2 µg/L), C reactive protein (CRP) (27.4 mg/L) and interleukin-6 (IL-6): 84.39 pg/ml). His nasopharyngeal swab for real-time polymerase chain reaction resulted positive. The patient was initially admitted to the pandemic clinic and the COVID-19 treatment protocol was commenced. However, he developed severe hypoxia that required emergency intubation and was transferred to the intensive care unit three days after hospitalization. He received mechanical ventilation, which required intravenous sedatives with a high fraction of inspired oxygen, high positive end-expiratory pressure, low tidal volume strategy, and concomitant rescue therapies (infusion of neuromuscular blocking agents, prone positioning, and inhaled vasodilators). Nevertheless, he had persistent hypoxemia and respiratory acidosis. Blood glucose levels were consistently high despite the adjusting insulin infusion. Serum sodium level measurements demonstrated fluctuations and required frequent blood sampling and correction of the imbalance. During his course in intensive care unit, his condition gradually deteriorated with hemodynamic alterations refractory to supportive treatment, spiked inflammatory markers (D-dimer: 13.500 µgr/L, CRP: 263.6 mg/L, ferritin: 281.8 µg/L and IL-6: 427.2 pg/ml), impaired liver and renal function tests. He was not suitable for extracorporeal therapies due to hemodynamic instability and died ten days later in the intensive care unit. Udrea et al. [4] described the first case of COVID-19 infection in a pediatric pati...

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Acute COVID-19 Infection in a Pediatric Patient with ROHHAD

Cited by 4 publications

References 12 publications

Coagulation Abnormalities and Clinical Complications in Children With SARS-CoV-2: A Systematic Review of 48,322 Patients

Coagulation Abnormalities and Clinical Complications in Children With SARS-CoV-2: A Systematic Review of 48,322 Patients

Nursing care recommendation for pediatric COVID-19 patients in the hospital setting: A brief scoping review

COVID-19 infection in a rare disease: ROHHAD syndrome

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