Acute covid-19 and multisystem inflammatory syndrome in children

Rubens, Jessica; Akindele, Nadine Peart; Tschudy, Megan M.; Sick-Samuels, Anna

doi:10.1136/bmj.n385

Cited by 75 publications

(81 citation statements)

References 38 publications

(65 reference statements)

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“…This was because the conditions are not triggered, exclusively, by COVID-19. The strategy retrieves references to secondary diseases linked to COVID-19 (Rubens, Akindele, Tschudy, & Sick-Samuels, 2021). It does not retrieve references, outside of the NICE remit, that do not state a link to COVID-19 (Shenker, Trogen, Schroeder, Ratner, & Kahn, 2020).…”

Section: Related Conditionsmentioning

confidence: 99%

The NICE COVID-19 search strategy for Ovid MEDLINE and Embase: developing and maintaining a strategy to support rapid guidelines

Levay

Finnegan

2021

Preprint

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Introduction The United Kingdom's (UK) National Institute for Health and Care Excellence (NICE) needs access to evidence on COVID-19 to develop rapid guidelines for healthcare professionals. This paper reports on how the NICE COVID-19 search strategy for identifying references in Ovid MEDLINE and Embase has been developed and maintained. Methods Each free-text line from the June 2020 version of the NICE COVID-19 search strategy was categorised as Critical, High, Medium, Low or Zero priority, according to the number of results and their relevance to NICE. Five search options were devised and tested by combining them with a search for drug treatments. The two prioritised options were compared to the COVID-19 Limit available in Ovid. New subject headings were tested and added. The selected option was refined to make the strategy simpler to use. Results The updated strategy combines free-text terms, categorised as Critical, High and Medium priority for NICE, with appropriate subject headings. Discussion The paper describes the challenges of maintaining a search strategy during the COVID-19 pandemic, as terminology continues to evolve. Conclusions A search strategy for identifying COVID-19 references, within the remit of NICE, has been developed. The recommended strategy could be considered for validation at an appropriate point in the pandemic. It is hoped that understanding how NICE has maintained its COVID-19 strategy will encourage further discussion on the challenges.

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Section: Related Conditionsmentioning

confidence: 99%

The NICE COVID-19 search strategy for Ovid MEDLINE and Embase: developing and maintaining a strategy to support rapid guidelines

Levay

Finnegan

2021

Preprint

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“…It is known that children can specific develop a multisystemic inflammatory syndrome during the COVID-19 clinical course (10). However, information of a more severe clinical course in patients with autoimmune or autoinflammatory condition is scarce.…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and COVID-19 outcomes in a regional cohort of pediatric patients with rheumatic diseases

Clemente

Udaondo

Arocena

et al. 2021

Preprint

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Background: This study aimed to assess the baseline characteristics and clinical outcomes of coronavirus disease 2019 (COVID-19) in pediatric patients with rheumatic and musculoskeletal diseases (RMD) and identify the risk factors associated with symptomatic or severe disease defined as hospital admission, intensive care admission or death. Methods: An observational longitudinal study was conducted during the first year of pandemic SARS-CoV-2 (1st March 2020 to 1st March 2021). All pediatric patients attended at the rheumatology outpatient clinic of six tertiary hospital in Madrid, Spain, with a medical diagnosis of RMD and COVID-19 were included. Main outcomes were symptomatic disease and hospital admission. The covariates were sociodemographic, clinical, and treatments. We ran a multivariable logistic regression model to assess risk factors for outcomes. Results: The study population included 77 pediatric patients. Mean age was 11.88 (4.04) years Of these, 30 patients were asymptomatic, 41 had a mild or moderate disease and other 6 patients (7.79%) required hospital admission related to COVID-19. The median length of stay was 5 (2-20) days and there was no death. Previous comorbidities increased the risk for symptomatic disease and hospital admission. Compared with outpatients, the factor independently associated with hospital admission was the use of glucocorticoids (OR 1.08; p=0.00). No statistically significant findings for symptomatic COVID-19 were found in the final model. Conclusion: Our data found no differences in COVID-19 outcomes between children-onset rheumatic diseases. Our results suggest that associated comorbidities and being in treatment with glucocorticoids increase the risk of hospital admission.

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“…In the UK, there has been a 5-fold higher rate of COVID-19 test positivity among children 5 to 12 years of age (0.35% prevalence) and adults ages 18 to 24 (0.36% prevalence) than in those 65 years of age or older 8 . Furthermore, of great concern is the increase of pediatric multisystem inflammatory syndrome (MIS-C) associated to COVID-19, which showed an incidence of about 100 affected children per week 9 . In Italy, the local national institute of health reports that after the emergence of the delta variant, the increase of COVID-19 cases involved the population 0-9 years old, while the older age groups showed a decline in cases 10 .…”

mentioning

confidence: 99%

Viewpoint of the European Pediatric Societies over Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccination in Children Younger Than Age 12 Years Amid Return to School and the Surging Virus Variants

Pettoello‐Mantovani¹,

Carrasco-Sanz²,

Huss³

et al. 2021

The Journal of Pediatrics

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Acute covid-19 and multisystem inflammatory syndrome in children

Cited by 75 publications

References 38 publications

The NICE COVID-19 search strategy for Ovid MEDLINE and Embase: developing and maintaining a strategy to support rapid guidelines

The NICE COVID-19 search strategy for Ovid MEDLINE and Embase: developing and maintaining a strategy to support rapid guidelines

Clinical characteristics and COVID-19 outcomes in a regional cohort of pediatric patients with rheumatic diseases

Viewpoint of the European Pediatric Societies over Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccination in Children Younger Than Age 12 Years Amid Return to School and the Surging Virus Variants

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