Acute corticosteroid myopathy in intensive care patients

Relationship between extracellular matrix, contractile apparatus, muscle mass and strength in case of glucocorticoid myopathy

“…This system distributes the forces of muscle contractions both in muscle and tendon. Extracellular matrix is also influenced by glucocorticoids [12,13].…”

Analysis of muscle proteins in acute quadriplegic myopathy

“…2,8,13,14 In addition, some investigators have discussed the difficulty encountered in fiber type differentiation due to poor staining of muscle fibers with ATPase stain. 1,9,10,11,22 There are several reports examining AQM from the viewpoint of muscle protein, 11,12,17,23 using slow and fast myosin monoclonal antibodies and actin antibody. However, numerous muscle fibers are not stained with slow and fast myosin monoclonal anti- Abbreviations: AQM-A, acute phase of acute quadriplegic myopathy; AQM-R, recovery phase of acute quadriplegic myopathy; MELAS, mitochondrial encephalomyopathy with lactic acidemia and stroke-like episodes.…”

“…1,9,22,23 On light microscopy, however, it may be difficult to differentiate muscle fiber types, due to poor staining of muscle fibers with adenosine triphosphatase (ATPase) stain. 1,9,10,11,22 Thus, it is difficult to conduct a detailed study of changes in muscle fibers by type using ATPase staining. We considered the use of another method for differentiating muscle fiber types when differentiation is inadequate by conventional ATPase staining.…”

Rhabdomyolysis after cerebral perfusion pressure-guided management in severe head injury

“…Other causes include muscle compression due to prolonged surgery, 8,9 hyperthermia, 10 intense shivering, seizure, 11 prolonged administration of propofol, 12 high-dose administration of glucocorticoids 13 mannitol-induced hyperosmolar states 15 and alcohol abuse. 16 In our patient, there were no associated injuries including extremity fractures or crush injury on physical examination.…”