Acute Coronary Syndromes: Differences in Men and Women

Kawamoto, Kris; Davis, Melinda B.; Duvernoy, Claire S.

doi:10.1007/s11883-016-0629-7

Cited by 63 publications

(55 citation statements)

References 102 publications

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“…There are known differences in how men and women are affected by CVD, with men showing a higher and earlier incidence but women showing a higher mortality rate (reviewed in 192,203 ). Sex differences related to intrauterine exposures and CVD risk are also common.…”

Section: Discussionmentioning

confidence: 99%

Intensive gestational glycemic management and childhood obesity: a systematic review and meta-analysis

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Intensive gestational glycemic management and childhood obesity: a systematic review and meta-analysis

et al. 2017

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“…Both risk factors for acute coronary syndrome, as well as the pathophysiological mechanism behind acute MI, differ in men and women. For example, plaque rupture is much less common in women compared to men [29].Our observational data do not allow us to further elucidate this finding and subsequent analyses have to be performed to study the specific role of circulating endostatin as a risk factor for ischemic heart disease in women.…”

Section: Possible Mechanisms For Observed Associationsmentioning

confidence: 87%

The association between circulating endostatin levels and incident myocardial infarction

Ruge

Carlsson

Jansson

et al. 2018

Scandinavian Cardiovascular Journal

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Objective. Increased levels of circulating endostatin have been observed in patients with prevalent ischemic heart disease. However, the association between circulating endostatin, and incident myocardial infarction (MI) is less studied. Our main aim was to study the association between circulating endostatin and incident MI in the community adjusted for established cardiovascular risk factors in men and women. Design. Circulating endostatin was measured in a nested case control study based on three large community-based Swedish cohorts, including 533 MI cases, and 1003 age-, sex-and cohort-matched controls. Odds ratios (OR) with 95% confidence intervals (CI) were calculated with adjustments for established cardiovascular risk factors. Results. Higher endostatin was associated with a higher incidence of MI independently of established cardiovascular risk factors (OR 1.19, 95% CI 1.03-1.37, p ¼ .02), but this association was abolished after additional adjustment for C-reactive protein. Sex-stratified analyses suggest that the association was substantially stronger in women as compared to men. Conclusions. In our community based sample, higher endostatin predicted incident myocardial infarction predominantly in women but not independently of CRP. Thus, our findings do not support a broad utility of endostatin measurements for the prediction of incident myocardial infarction in clinical practice. ARTICLE HISTORY

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“…Significant advances have been made in the diagnosis and treatment of cardiovascular disease, but most have been tailored to the recognition and treatment of the disease in men [ 2 ]. Substantially less research has been done to study the growing issue of the disease in women [ 3 ]. Women tend to present with atypical symptoms and experience coronary artery disease (CAD) later in life than men.…”

Section: Introductionmentioning

confidence: 99%

2-Dimensional Speckle Tracking Echocardiography predicts severe coronary artery disease in women with normal left ventricular function: a case-control study

Hubbard

Calle

Barros-Gomes

et al. 2017

BMC Cardiovasc Disord

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BackgroundWomen who have coronary artery disease (CAD) often present with atypical symptoms that may lead to misdiagnosis. We assessed strain, systolic strain rate and left ventricular dyssynchrony with 2- dimensional- speckle tracking echocardiography to evaluate its use as a non-invasive method for detecting CAD in women with normal ejection fraction compared with healthy women controls with a normal angiogram.MethodsWe included 35 women with CAD confirmed by coronary angiography and a positive exercise stress echocardiography and 35 women in a control group with a low pretest probability of CAD, normal angiogram and a normal stress echocardiography with normal EF.ResultsStatistically significant 2D-STE findings for the CAD vs control groups were as follows for the mean of: global circumferential strain (CS) (−19.4% vs −22.4%, P = .02); global radial S (49% vs 34%, P = .03); global radial SR (2.4 s−1 vs 1.9 s−1, P = .05); global longitudinal LV S (GLS) (−14.3% vs −17.2%, P < .001). For mechanical dyssynchrony, SD of the GLS time-to-peak (TTP) was computed (99 vs 33 ms, P < .001). The receiver operating characteristic and area under the curve (AUC) were calculated. A cutoff value of 45 ms for 1 SD of the longitudinal S TTP had 97% sensitivity and 89% specificity (AUC, 0.96). GLS cutoff value of −15.87% had 71% sensitivity and 74% specificity; AUC, 0.74 in differentiating CAD and control groups. The combined GLS, CS, and SD of the longitudinal S TTP had an AUC of 0.96 (sensitivity 97%, specificity 86%). Interclass correlations of the GLS segment and GLS TTP measurements were 0.49 (95% CI, 0.227-0.868) and 0.74 (95% CI, 0.277-0.926), respectively.ConclusionIn women with a normal echocardiogram and LVEF, CAD can be identified by dyssynchrony and abnormal strain values, as evidenced by 2D-STE.

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Acute Coronary Syndromes: Differences in Men and Women

Cited by 63 publications

References 102 publications

Intensive gestational glycemic management and childhood obesity: a systematic review and meta-analysis

Intensive gestational glycemic management and childhood obesity: a systematic review and meta-analysis

The association between circulating endostatin levels and incident myocardial infarction

2-Dimensional Speckle Tracking Echocardiography predicts severe coronary artery disease in women with normal left ventricular function: a case-control study

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