Acute coronary syndrome secondary to coronary artery aneurysms: Case reports and review

Jariwala, Pankaj; Padmakumar, Edla Arjun; Krishnaprasad, Adluri Rajeshwara

doi:10.1016/j.ihjccr.2018.03.002

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…The abnormal diameter of the coronary artery is twice or more than the normal diameter, which is a coronary aneurysm (Syed, 1997;Pahlavan and Niroomand, 2006;Jariwala et al, 2018) (Coronary Artery Aneurysm, CAA).…”

Section: Introductionmentioning

confidence: 99%

Hemodynamic Mechanism of Coronary Artery Aneurysm High Occurrence on Right Coronary Artery

Wang

Xie

et al. 2020

Front. Physiol.

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The abnormal diameter of the coronary artery is twice or more than the normal diameter, which is a coronary artery aneurysm (CAA). According to the clinical statistics, CAA shows high occurrence on right coronary artery (RCA). The most common cause of CAA in adults is atherosclerosis, which destroys the elastic fibers in the middle layer of the blood vessel. Under the intravascular pressure, the weak wall bulges outward and form CAA. This article aims to explain the hemodynamic mechanism of coronary artery aneurysm shows high occurrence on RCA. Occurrence of CAA was simulated by the volume growth of coronary artery. Firstly, a 0-3D multi-scale model of normal coronary artery was constructed to obtain the hemodynamic environments of coronary artery. Then, fluid-structure interaction of normal and atherosclerotic blood vessel was performed to obtain volume growth rate of the coronary artery. Atherosclerosis was simulated by modifying Young's modulus in middle layer of the blood vessel. Finally, creep simulation was performed to compare the deformation of the blood vessels under the accumulation of time. Under normal condition, the volume growth rate of the RCA is 2.28 times and 1.55 times of the LAD and the LCX. After atherosclerosis, the volume growth rate of the RCA was 2.69 times and 2.12 times of the LAD and the LCX. And the volume growth rate of the RCA was 3.85 times and 3.45 times of the LAD and the LCX after further deepening of atherosclerosis. The expansion time above the average volume growth rate of the RCA, the LAD and the LCX respectively were 0.194, 0.168 and 0.179 s. The RCA is 2.06 times the original, the LAD and LCX are 1.53 times and 1.56 times after 10 years in creep simulation. It can be concluded that the RCA is more prone to aneurysms originated from the larger expansion of the RCA under normal physiological condition, and the larger expansion is magnified under atherosclerosis condition with destroyed vessel elasticity, and further magnified during the time accumulated viscoelastic creep to develop to aneurysm eventually.Keywords: coronary artery aneurysm, high occurrence on right coronary artery, geometric multi-scale model, fluid-structure interaction, creep simulation Frontiers in Physiology | www.frontiersin.org 1

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Section: Introductionmentioning

confidence: 99%

Hemodynamic Mechanism of Coronary Artery Aneurysm High Occurrence on Right Coronary Artery

Wang

Xie

et al. 2020

Front. Physiol.

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Diagnostic workup and treatment options for aneurysmal coronary artery disease

Barioli,

Visco,

Pellizzari

et al. 2024

Vessel Plus

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Coronary artery aneurysms and coronary ectasia are defined as focal or diffuse dilation of the coronary arteries, respectively. Although frequently silent and detected as incidental findings at coronary angiography or computed tomography, coronary aneurysms have been associated with different clinical conditions, including silent ischemia and acute coronary syndromes, and with poor clinical outcomes. The optimal management still remains unsettled, as randomized data are lacking and treatment with either surgical or percutaneous procedures faces significant challenges. This review aims to provide an update on the classification, etiopathogenesis, diagnostic workup, and treatment of aneurysmal coronary disease.

show abstract

Acute coronary syndrome secondary to coronary artery aneurysms: Case reports and review

Cited by 2 publications

References 41 publications

Hemodynamic Mechanism of Coronary Artery Aneurysm High Occurrence on Right Coronary Artery

Hemodynamic Mechanism of Coronary Artery Aneurysm High Occurrence on Right Coronary Artery

Diagnostic workup and treatment options for aneurysmal coronary artery disease

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