Acute coronary syndrome presenting after pseudoephedrine use and regression with beta-blocker therapy

Akay, Serhat; Ozdemir, Metehan

doi:10.1016/s0828-282x(08)70200-9

Cited by 21 publications

(13 citation statements)

References 4 publications

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“…As the highest dose represents half the LD 50 , we could be reasonably assured that any effects of PSE would be evident, but the dose was not high enough to cause seizure or death in the absence of HBO. It should be noted that high doses of PSE have been shown to cause cardiovascular complications (Akay and Ozdemir ; Fidan et al. ) and that these may affect LS by altering circulation or cerebral perfusion; however, we posit that this is simply an additional mechanism by which PSE may affect divers and does not confound interpretation of the results.…”

Section: Discussionmentioning

confidence: 67%

Female rats are more susceptible to central nervous system oxygen toxicity than male rats

et al. 2014

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Tonic–clonic seizures typify central nervous system oxygen toxicity (CNS‐OT) in humans and animals exposed to high levels of oxygen, as are encountered during scuba diving. We previously demonstrated that high doses of pseudoephedrine (PSE) decrease the latency to seizure (LS) for CNS‐OT in young male rats. This study investigated whether female rats respond similarly to PSE and hyperbaric oxygen (HBO). We implanted 60 virgin stock (VS) and 54 former breeder (FB) female rats with radio‐telemetry devices that measured brain electrical activity. One week later, rats were gavaged with saline or PSE in saline (40, 80, 120, 160, or 320 mg/kg) before diving to five atmospheres absolute in 100% oxygen. The time between reaching maximum pressure and exhibiting seizure was LS. Vaginal smears identified estrus cycle phase. PSE did not decrease LS for VS or FB, primarily because they exhibited low LS for all conditions tested. VS had shorter LS than males at 0, 40, and 80 mg/kg (−42, −49, and −57%, respectively). FB also had shorter LS than males at 0, 40, and 80 mg/kg (−60, −86, and −73%, respectively). FB were older than VS (286 ± 10 days vs. 128 ± 5 days) and weighed more than VS (299 ± 2.7 g vs. 272 ± 2.1 g). Males tested were younger (88 ± 2 days), heavier (340 ± 4.5 g), and gained more weight postoperatively (7.2 ± 1.6 g) than either VS (−0.4 ± 1.5 g) or FB (−1.6 ± 1.5 g); however, LS correlated poorly with age, body mass, change in body mass, and estrus cycle phase. We hypothesize that differences in sex hormones underlie females' higher susceptibility to CNS‐OT than males.

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Section: Discussionmentioning

confidence: 67%

Female rats are more susceptible to central nervous system oxygen toxicity than male rats

et al. 2014

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“…Case reports suggesting that pseudoephedrine could cause tachycardia, coronary artery spasm and MI, during its use for symptomatic treatment, have been published [4,5,15]. It is interesting to note that these suggested complications were seen in cases without coronary disease.…”

Section: Discussionmentioning

confidence: 99%

Effect of Pseudoephedrine on Cardiac Rhythm of Children with Rhinitis

et al. 2011

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“…Pseudoefedrina, componente comum em antigripais, suplementos dietéticos e chás de ervas chineses, apresenta efeitos simpaticomiméticos com impacto no sistema cardiovascular. IAM com coronariografia normal iniciado após ingestão de medicamentos com pseudoefedrina já foi descrito 30 .…”

Section: Síndrome Coronariana Aguda E Coronariografia Normalunclassified

Value of Cardiac Magnetic Resonance Image in the Approach of the Patient with Suspect Acute Coronary Syndrome and Normal Angiography

Santana¹

2014

Arquivos Brasileiros De Cardiologia - Imagem Cardiovascular

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Resumo E s t i m a -s e q u e p a c i e n t e s a d m i t i d o s c o m d o rtorácica, níveis elevados de troponina e alterações eletrocardiográficas com coronariografia normal ou discretamente alterada representem 2,6% a 19% dos casos inicialmente diagnosticados como infarto agudo do miocárdio. Nessa situação, o diagnóstico adequado é um desafio para o cardiologista. A ressonância magnética cardiovascular tem sido usada como um importante instrumento para definição entre infarto agudo do miocárdio real e uma doença que simule esse diagnóstico, conduzindo ao tratamento adequado e melhora no prognóstico. Resumo E s t i m a -s e q u e p a c i e n t e s a d m i t i d o s c o m d o rtorácica, níveis elevados de troponina e alterações eletrocardiográficas com coronariografia normal ou discretamente alterada representem 2,6% a 19% dos casos inicialmente diagnosticados como infarto agudo do miocárdio. Nessa situação, o diagnóstico adequado é um desafio para o cardiologista. A ressonância magnética cardiovascular tem sido usada como um importante instrumento para definição entre infarto agudo do miocárdio real e uma doença que simule esse diagnóstico, conduzindo ao tratamento adequado e melhora no prognóstico.

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Acute coronary syndrome presenting after pseudoephedrine use and regression with beta-blocker therapy

Cited by 21 publications

References 4 publications

Female rats are more susceptible to central nervous system oxygen toxicity than male rats

Female rats are more susceptible to central nervous system oxygen toxicity than male rats

Effect of Pseudoephedrine on Cardiac Rhythm of Children with Rhinitis

Value of Cardiac Magnetic Resonance Image in the Approach of the Patient with Suspect Acute Coronary Syndrome and Normal Angiography

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