Acute coronary syndrome and renal impairment: a systematic review

Mauro, Marco Di; Fiorentini, Vincenzo; Mistrulli, Raffaella; Veneziano, Francesco Antonio; Luca, Leonardo De

doi:10.31083/j.rcm2302049

Cited by 6 publications

(5 citation statements)

References 63 publications

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“…Heart and kidney injuries can cause each other and the superposition of injuries is amplified. 35 , 36 As serum creatinine levels are the most commonly used measure of kidney function, it may have an influential impact on cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Age–Bilirubin–International Normalized Ratio (INR)–Creatinine (ABIC) Score, a Potential Prognostic Model for Long-Term Mortality of CAD Patients After PCI

Wang

Pan

Zheng

et al. 2023

JIR

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Background Given that age, international normalized ratio (INR), total bilirubin, and creatinine are reported to be independent risk factors for predicting outcome in patients with coronary artery disease (CAD), it is possible that the age–bilirubin–INR–creatinine (ABIC) score might be a potential prognostic model for patients with CAD. Methods A total of 6046 CAD patients after percutaneous coronary intervention (PCI) from the retrospective cohort study (Identifier: ChiCTR-ORC-16010153) were evaluated finally. The primary outcome long-term mortality and secondary endpoints mainly major adverse cardiovascular and cerebrovascular events (MACCEs) were recorded. Multivariate Cox regression models were used to determine risk factors for mortality and MACCEs. Results The ABIC score was significantly higher in the death group than in the survival group. After adjusting for other CAD risk factors, the ABIC score was identified to be an independent risk factor for long-term mortality by multivariate Cox analysis. When in the high ABIC group, the incidence of all-cause mortality would increased 1.7 times (adjusted HR=1.729 (1.347–2.218), P <0.001), and 1.5 times for cardiac death (adjusted HR=1.482 (1.126–1.951), P =0.005). Conclusion The present study indicated that ABIC score≥7.985 predicts high long-term mortality and cardiac death risk for PCI patients. The ABIC score might be a potential prognostic model for patients with PCI.

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Section: Discussionmentioning

confidence: 99%

Age–Bilirubin–International Normalized Ratio (INR)–Creatinine (ABIC) Score, a Potential Prognostic Model for Long-Term Mortality of CAD Patients After PCI

Wang

Pan

Zheng

et al. 2023

JIR

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“…Chronic kidney diseases patients have a higher risk of ischemia and AMI and a worse prognosis, especially in dialysis patients. Both cardiac and renal insufficiency can aggravate the prognosis and lead to disease progression [ 28 ]. Type 2 diabetes is another critical factor, increasing the risk of major adverse cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

Performance of the Risk Scores for Predicting In-Hospital Mortality in Patients with Acute Coronary Syndrome in a Chinese Cohort

Bai,

Li,

Yang

et al. 2023

Rev. Cardiovasc. Med.

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Background:The prognosis of patients with acute coronary syndrome (ACS) varies greatly, and risk assessment models can help clinicians to identify and manage high-risk patients. While the Global Registry of Acute Coronary Events (GRACE) model is widely used, the clinical pathways for acute coronary syndromes (CPACS), which was constructed based on the Chinese population, and acute coronary treatment and intervention outcomes network (ACTION) have not yet been validated in the Chinese population. Methods: Patients with ACS who underwent coronary angiography or percutaneous coronary intervention from 2011 to 2020, were retrospectively recruited and the appropriate corresponding clinical indicators was obtained. The primary endpoint was in-hospital mortality. The performance of the GRACE, GRACE 2.0, ACTION, thrombolysis in myocardial infarction (TIMI) and CPACS risk models was evaluated and compared. Results: A total of 19,237 patients with ACS were included. Overall, in-hospital mortality was 2.2%. ACTION showed the highest accuracy in predicting discriminated risk (c-index 0.945, 95% confidence interval [CI] 0.922-0.955), but the calibration was not satisfactory. GRACE and GRACE 2.0 did not significantly differ in discrimination (p = 0.1480). GRACE showed the most accurate calibration in all patients and in the subgroup analysis of all models. CPACS (c-index 0.841, 95% CI 0.821-0.861) and TIMI (c-index 0.811, 95% CI 0.787-0.835) did not outperform (c-index 0.926, 95% CI 0.911-0.940). Conclusions: In contemporary Chinese ACS patients, the ACTION risk model's calibration is not satisfactory, although outperformed the gold standard GRACE model in predicting hospital mortality. The CPACS model developed for Chinese patients did not show better predictive performance than the GRACE model.

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“…The frequency of chronic kidney injury which is known to increase cardiovascular events for many reasons, such as chronic inflammation, oxidative stress, endothelial dysfunction, and calcification increases up to 20%-25% in ACS patients. [9,10] As suggested by these findings, CAD is often accompanied by anemia and impaired renal function. This association, which is frequently seen in patients with ACS, has been evaluated in studies, and a relationship has been shown of anemia and impaired renal function with increased early and long-term mortality and adverse outcomes in patients with ACS.…”

Section: Demir Et Al • Medicine (2023) 102:41mentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

The relationship of the hemoglobin to serum creatinine ratio with long-term mortality in patients with acute coronary syndrome: A retrospective study

Demir,

Kahraman,

Sen

et al. 2023

Medicine

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Acute coronary syndrome (ACS) is an urgent clinical condition of cardiovascular diseases. The present study evaluated the predictive efficacy of the hemoglobin to serum creatinine ratio (Hgb/Cr) on long-term mortality in patients with ACS. The ratio, representing the proportion of the 2 values, is cheap, practical, and very easy to calculate at the bedside. Our study included 475 patients who were admitted to the coronary intensive care unit with a diagnosis of ACS and who underwent coronary angiography. The Hgb/Cr ratio was calculated by dividing the admission hemoglobin by the admission serum creatinine. All patient data were collected from the electronic hospital information system, patient files, and the hospital’s archive. A comparison of the patients laboratory findings revealed that the Hgb/Cr ratios differed significantly between the survivor and non-survivor group [16.6 (7.7–49) vs 13.8 (4.91–32.8), respectively; P < .001]. A univariate Cox regression analysis showed that the Hgb/Cr ratio was statistically significant in predicting long-term mortality (0.836; 95% confidence interval [CI]: 0.781–0.895; P < .001). After adjusting the model by adding clinically and statistically significant variables, the Hgb/Cr ratio was still an independent predictor of long-term mortality (0.886; 95% CI: 0.815–0.963; P = .004). The Hgb/Cr ratio’s discriminant ability was tested with an receiver operating characteristic curve analysis. The Hgb/Cr ratio’s area under the curve value was 0.679 (95% CI: 0.609–0.750; P < .001). A survival analysis using the Kaplan–Meier curve of the 2 Hgb/Cr ratio groups (according to cutoff value) revealed that the low-Hgb/Cr group had a significantly higher mortality rate than high-Hgb/Cr group. The Hgb/Cr ratio was found to be an independent predictor of long-term mortality in ACS patients.

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Acute coronary syndrome and renal impairment: a systematic review

Cited by 6 publications

References 63 publications

Age–Bilirubin–International Normalized Ratio (INR)–Creatinine (ABIC) Score, a Potential Prognostic Model for Long-Term Mortality of CAD Patients After PCI

Age–Bilirubin–International Normalized Ratio (INR)–Creatinine (ABIC) Score, a Potential Prognostic Model for Long-Term Mortality of CAD Patients After PCI

Performance of the Risk Scores for Predicting In-Hospital Mortality in Patients with Acute Coronary Syndrome in a Chinese Cohort

The relationship of the hemoglobin to serum creatinine ratio with long-term mortality in patients with acute coronary syndrome: A retrospective study

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