Toxic endothelitis is endothelial dysfunction after topical, systemic or intraocular use of substances leading to corneal stromal edema, endothelial pigment deposits with anterior chamber reaction. Causative agents include topical Benzalkonium chloride, Chlorhexidine, Ultraviolet-A, oral amantidine and alcohol consumption. We report a rare case of 51 year old female patient with bilateral toxic endothelitis with inadvertent use of ayurvedic topical drug containing juice of Allium cepa-onion juice-1.68ml, juice of Zingiber officinale-ginger juice-1.66ml, juice of Citrus aurantifolia-lemon juice-1.66ml, honey-5.00ml, benzalkonium chloride (0.01%) and its successful management with short course of topical corticosteroids Delhi J Ophthalmol 2019;30;44-45; Doi http://dx.doi.org/10.7869/djo.478