Acute Corneal Calcification Following Chemical Injury

Abstract

The insolubility, elemental composition, and ultrastructural appearance suggest that the opacity was caused by calcium phosphate deposition. The absence of phosphorus from the listed components of the fire retardant suggests that the use of phosphate-buffered irrigation fluid or the subsequent use of phosphate-buffered drops may have contributed to the deposition of this insoluble crystalline deposit.

New insight into non-healing corneal ulcers: iatrogenic crystals

“…19,23 Bernauer et al 24 reported potential adverse effects of intensified sodium hyaluronate artificial tears in patients with various ocular surface conditions. The authors describe five cases of deep corneal calcium crystal deposition, ultimately requiring keratoplasty.…”

Surgical rehabilitation following severe ocular burns

“…The buffer and other excipients of the irrigating fluid and other topical medications should not be phosphate-based, as this can lead to acute corneal calcification. 5,6 Mechanisms of ocular damage and early intervention Understanding the mechanism of alkali injury has lead to a rational approach to management. Alkaline agents damage tissues by a variety of mechanisms.…”

Ultrasound biomicroscopy as a diagnostic method of corneal degeneration and inflammation

“…The etiology of corneal calcification has been classified as metastatic or dystrophic processes, although the mechanism is still unclear (38).…”

“…a) The superficial type appears as a band shaped keratopathy and refers to calcium deposition in the Bowman layer and superficial structures (36)(37)(38). The causes of superficial calcification of the cornea are unknown.…”

“…The tear pH may be more alkaline as a result of evaporation and desiccation (38,39). Dystrophic calcium deposition can occure in case of superficial inflammation or tissue injury (38)(39)(40)(41)(42)(43)(44).…”