Acute Compartment Syndrome Following Thrombolysis For Acute Lower Limb Ischemia

Grip, Olivia; Petter, Lindahl; Håkan, Pärsson

doi:10.1016/j.avsg.2021.07.015

Cited by 6 publications

(2 citation statements)

References 36 publications

(60 reference statements)

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“…In healthy individuals, intramuscular pressures in the anterior tibial compartment were measured and found to be lower in females than in males during exercise 26 . In a larger retrospective study of patients undergoing thrombolysis for ALI, 9.4% of females and 12.7% of males underwent therapeutic fasciotomy, as a surrogate for clinical acute compartment syndrome, without reaching statistically significant difference between sexes 27 . Although challenging, large prospective studies with preset criteria and objective measures to diagnose acute compartment syndrome would be needed to establish whether sex is an important factor for the development of acute compartment syndrome after revascularization for ALI.…”

Section: Discussionmentioning

confidence: 99%

Sex differences in outcomes after revascularization for acute lower limb ischemia: Propensity score adjusted analysis

Karonen,

Eek,

Butt

et al. 2024

World j. surg.

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BackgroundPrevious reports have suggested higher rates of mortality and amputation for female patients in acute lower limb ischemia (ALI). The aims of the present study were to investigate if there is a difference in mortality, amputation, and fasciotomy between the sexes.MethodsA retrospective cohort study of consecutive patients undergoing index revascularization for ALI between 2001 and 2018 was conducted. A propensity score was created through a logistic regression with female/male sex as an outcome. Cox regression analyses for 90‐day and 1‐year mortality, combining major amputation/mortality, and logistic regression for major bleeding and fasciotomy, were performed. All analyses were performed with and without adjusting for propensity score.ResultsA total of 709 patients were included in the study of which 45.9% were women. Mean age was 72.1 years. Females were older and had higher rates of atrial fibrillation, embolic disease, and lower estimated glomerular filtration rate, while men more often had anemia and chronic peripheral arterial disease. Mortality at 1 year was 21.2% for women and 14.7% for men. The adjusted hazard ratio for 1‐year mortality was 0.99 (95% CI 0.67–1.46). Fasciotomy was performed in 7.1% of female and 12.8% of male patients; the adjusted odds ratio was 0.52 (95% CI 0.29–0.91).ConclusionSex was not found to be an independent risk factor for mortality or combined major amputation/mortality after revascularization for acute lower limb ischemia, whereas women had lower odds of undergoing fasciotomy. Whether women are underdiagnosed or do not develop acute compartment syndrome in the lower leg as often as men should be evaluated prospectively.

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Section: Discussionmentioning

confidence: 99%

Sex differences in outcomes after revascularization for acute lower limb ischemia: Propensity score adjusted analysis

Karonen,

Eek,

Butt

et al. 2024

World j. surg.

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“…Risk factors of compartment include prolonged ischemia time, young age, inadequate arterial collaterals, acute onset, and hypotension. 78 Diagnosis is based on clinical criteria including pain on flexion or passive extension of the foot, paraesthesia, anesthesia, paresis, or paralysis of the limb. Fasciotomy should be performed promptly because it relieves muscle compression, restores capillary blood flow, and restores the caliber of arteries and veins.…”

Section: Reperfusion Injury and Compartment Syndromementioning

confidence: 99%

Management of Acute Complications during Endovascular Procedures in Peripheral Arterial Disease: A Review

Kumar

Valakkada

Ayyappan

et al. 2022

Journal of Clinical Interventional Radiology ISVIR

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Endovascular therapy, as opposed to surgical bypass, has become the mainstay for peripheral arterial disease even in long segment occlusions. Complications can occur during the arterial access, catheter manipulation, balloon dilation, and/or stent placement. Given the high prevalence of comorbidities such as diabetes, hypertension, renal dysfunction, and coronary artery disease in these patients, early identification of procedural complications and initiation of treatment are of paramount importance. This review aims to provide comprehensive data on the identification and management of commonly encountered endovascular complications during endovascular interventions in peripheral arterial disease.

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Prophylactic and Therapeutic Fasciotomy for Acute Compartment Syndrome after Revascularization for Acute Lower Limb Ischemia—Renal and Wound Outcomes

Karonen¹,

Eek²,

Butt³

et al. 2023

Annals of Vascular Surgery

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Acute Compartment Syndrome Following Thrombolysis For Acute Lower Limb Ischemia

Cited by 6 publications

References 36 publications

Sex differences in outcomes after revascularization for acute lower limb ischemia: Propensity score adjusted analysis

Sex differences in outcomes after revascularization for acute lower limb ischemia: Propensity score adjusted analysis

Management of Acute Complications during Endovascular Procedures in Peripheral Arterial Disease: A Review

Prophylactic and Therapeutic Fasciotomy for Acute Compartment Syndrome after Revascularization for Acute Lower Limb Ischemia—Renal and Wound Outcomes

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