Acute cholecystitis secondary to dog bite

Elliott, James H.; Donaldson, Eric F.

doi:10.1016/j.ijscr.2019.02.012

Cited by 5 publications

(2 citation statements)

References 16 publications

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“…4 The clinical manifestations of C. canimorsus infections reported in Australia include bacteraemia, septic shock, acute cholecystitis, rupture of mycotic common iliac aneurysm and endophthalmitis. 6,[10][11][12][13][14][15] Worldwide, it also causes other disease entities including fever of unknown origin, cellulitis, pneumonia, endocarditis, septic arthritis and peritonitis associated with peritoneal dialysis. 3 C. canimorsus meningitis is considered rare, with a reported annual incidence of 0.03 per million in a population study in the Netherlands.…”

Section: Discussionmentioning

confidence: 99%

Culture‐negative Capnocytophaga canimorsus meningitis diagnosed by 16s ribosomal RNA polymerase chain reaction in an immunocompetent veterinarian and a review of the literature

Lam

Horvath

Amodeo

2023

Internal Medicine Journal

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Capnocytophaga canimorsus is a fastidious, capnophilic and facultative anaerobic Gram‐negative rod found commonly in the oral flora of dogs that may cause zoonotic infections such as cellulitis and eye infections. In immunocompromised patients, it may cause fulminant sepsis. Meningitis due to C. canimorsus is, however, a rare manifestation. This is the first reported case of C. canimorsus meningitis in Australia in an immunocompetent veterinarian diagnosed by 16s ribosomal RNA polymerase chain reaction.

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Section: Discussionmentioning

confidence: 99%

Culture‐negative Capnocytophaga canimorsus meningitis diagnosed by 16s ribosomal RNA polymerase chain reaction in an immunocompetent veterinarian and a review of the literature

Lam

Horvath

Amodeo

2023

Internal Medicine Journal

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“…Unlike the atypical pathogen and patient phenotypes, the clinical presentation was mostly in line with common C. canimorsus sepsis features, including acute kidney injury [8, 9, 11, 13, 14], coagulopathy [13], TTP [8, 13], liver dysfunction [13, 14], and septic shock [8, 11, 13], as well as petechial rash [8, 14] and abdominal pain [8, 13, 14] upon presentation to hospital. The initial afebrile presentation however has been less frequently reported [7, 11, 13], while cholecystitis appears to be a rare, but not unheard of C. canimorsus complication [14, 15].…”

Section: Discussionmentioning

confidence: 99%

Rapid diagnosis of Capnocytophaga canimorsus septic shock in an immunocompetent individual using real-time Nanopore sequencing: a case report

et al. 2019

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Background Rapid diagnosis and appropriate treatment is imperative in bacterial sepsis due increasing risk of mortality with every hour without appropriate antibiotic therapy. Atypical infections with fastidious organisms may take more than 4 days to diagnose leading to calls for improved methods for rapidly diagnosing sepsis. Capnocytophaga canimorsus is a slow-growing, fastidious gram-negative bacillus which is a common commensal within the mouths of dogs, but rarely cause infections in humans. C. canimorsus sepsis risk factors include immunosuppression, alcoholism and elderly age. Here we report on the application of emerging nanopore sequencing methods to rapidly diagnose an atypical case of C. canimorsus septic shock. Case presentation A 62 year-old female patient was admitted to an intensive care unit with septic shock and multi-organ failure six days after a reported dog bite. Blood cultures were unable to detect a pathogen after 3 days despite observed intracellular bacilli on blood smears. Real-time nanopore sequencing was subsequently employed on whole blood to detect Capnocytophaga canimorsus in 19 h. The patient was not immunocompromised and did not have any other known risk factors. Whole-genome sequencing of clinical sample and of the offending dog’s oral swabs showed near-identical C. canimorsus genomes. The patient responded to antibiotic treatment and was discharged from hospital 31 days after admission. Conclusions Use of real-time nanopore sequencing reduced the time-to-diagnosis of Capnocytophaga canimorsus in this case from 6.25 days to 19 h. Capnocytophaga canimorsus should be considered in cases of suspected sepsis involving cat or dog contact, irrespective of the patient’s known risk factors. Electronic supplementary material The online version of this article (10.1186/s12879-019-4173-2) contains supplementary material, which is available to authorized users.

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Capnocytophaga canimorsus– a potent pathogen in immunocompetent humans – systematic review and retrospective observational study of case reports

Mader

Lührs

Langenbeck

et al. 2019

Infectious Diseases

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Acute cholecystitis secondary to dog bite

Abstract: Highlights This is the second known case of Cholecystitis due to Capnocytophaga canimorsus. Accurate diagnosis of this condition requires thorough history and examination. Prolonged targeted antibiotic therapy may be required for symptom resolution.

Cited by 5 publications

References 16 publications

Culture‐negative Capnocytophaga canimorsus meningitis diagnosed by 16s ribosomal RNA polymerase chain reaction in an immunocompetent veterinarian and a review of the literature

Culture‐negative Capnocytophaga canimorsus meningitis diagnosed by 16s ribosomal RNA polymerase chain reaction in an immunocompetent veterinarian and a review of the literature

Rapid diagnosis of Capnocytophaga canimorsus septic shock in an immunocompetent individual using real-time Nanopore sequencing: a case report

Capnocytophaga canimorsus– a potent pathogen in immunocompetent humans – systematic review and retrospective observational study of case reports

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