Acute Cholangitis

Shimada, Hiroshi; Nihmoto, Shuichi; Matsuba, Akira; Nakagawara, Gizo

doi:10.1097/00004836-198804000-00019

Cited by 13 publications

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“…One of these 2 cases was ABO incompatible (and ABO incompatibility has an impact on venous thrombosis) [14,18,19 ]with well-controlled titers after liver transplantation, whereas the other case was compatible. A possible explanation for these findings is the mutual relationship between biliary stenosis and portal venous thrombosis via the hepatic sinusoid [20,21,22]. Close follow-up is still required in 1 case because of the portal thrombosis since this patient showed slightly delayed excretion in the anterior segment in biliary scintigraphy.…”

Section: Discussionmentioning

confidence: 99%

Liver Transplantation for Congenital Biliary Dilatation: A Single-Center Experience

et al. 2010

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Background: Congenital biliary dilatation is a rare disease. Although the possibility of refractory cholangitis and/or the frequency of malignant tumors legitimize hepatobiliary surgery, repeated cholangitis and biliary obstruction result in secondary liver cirrhosis even after polysurgery. There are no definitive guidelines on liver transplantation for congenital biliary dilatation. Patients: A total of 1,101 liver transplantation recipients were enrolled in this study. Eleven patients with congenital biliary dilatation including 5 patients with Caroli’s disease were retrospectively analyzed in detail. Results: Nine of 11 patients underwent initial operations before liver transplantation while 2 patients with Caroli’s disease received liver transplantation as initial surgery, with good outcomes. All patients had intractable symptoms caused by liver cirrhosis, and growth delay was considerable in patients aged <20 years. Histopathological analysis of the native liver revealed hepatic fibrosis (≧F2). One patient with ABO incompatibility died. One patient with Caroli’s disease accompanied with intrahepatic carcinoma survives 11.8 years after liver transplantation without any recurrences. Conclusions: Patients with congenital biliary dilatation with refractory symptoms and complications secondary to liver failure are appropriate candidates for liver transplantation. We suggest that liver transplantation is an effective therapeutic option for patients with congenital biliary dilatation with due consideration to many accompanying factors, such as clinical course, growth delay, image findings and histopathological analysis.

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