Acute changes in endothelin-1 after hemodialysis for chronic renal failure

Ross, Robert D.; Kalidindi, Vijay; Vincent, Julie A.; Kassab, Joseph; Dabbagh, Shermine; Hsu, Julie M.; Pinsky, William W.

doi:10.1016/s0022-3476(09)90047-6

Cited by 23 publications

(14 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agreement with an earlier report by Koyama et al [4], others have also found a decrease in plasma ET-1 concentrations on hemodialysis [7, 8], in contrast to those who reported unchanged [5, 11, 13]or even increased [14]plasma ET-1 after a hemodialysis session. In addition, it was not clarified whether volume loss associated with ultrafiltration or hemodialysis is responsible for changes in plasma ET-1 associated with hemodialysis [11, 13, 14, 15, 16]. …”

Section: Introductionsupporting

confidence: 92%

“…Indeed, we did not apply isolated ultrafiltration in our study so that changes observed after the first stage of the dialysis session can be attributable to a combination of ultrafiltration and hemodialysis. On the other hand, Ross et al [14]who studied a population of hemodialyzed children, similarly to Peco-Antic et al [15], found a correlation between the magnitude of volume loss and dialysis-induced rises of ET-1. This is consistent with the analogical correlation in our hypertensive ESRF patients and suggests that not blood depuration but ultrafiltration is pathophysiologically linked to augmentation of ET-1 production during a dialysis session.…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Effect of a Hemodialysis Session on Plasma Levels of Endothelin-1 in Hypertensive and Normotensive Subjects with End-Stage Renal Failure

Surdacki

Sułowicz

Wieczorek-Surdacka

et al. 1999

Nephron

View full text Add to dashboard Cite

Background: Elevated plasma endothelin-1 (ET-1) was found in end-stage renal failure (ESRF). However, there are discordant reports on the influence of hypertension on plasma ET-1 in ESRF and on the effect of hemodialysis on ET-1 concentrations. Aim: To compare the time course of plasma ET-1 during hemodialysis in hypertensive (HT) and normotensive (NT) ESRF patients. Methods: Plasma ET-1 and mean blood pressure (MP) were measured in 12 HT patients and 11 matched NT patients on maintenance hemodialysis at baseline (B), after a 2.5–3.5 h hemodialysis with ultrafiltration (P1) and after a subsequent 1 h isovolumic dialysis (P2). Results: In HT patients, plasma ET-1 increased at P1 with no further change after P2 (B vs. P1 and P2, p < 0.05). In NT patients, ET-1 levels were similar at B, P1 and P2. In HT, but not in NT subjects, volume loss correlated with change of ET-1 at P1. In HT patients, MP fell during P1 and tended to return towards baseline at P2. In NT patients, MP dropped after P1 and remained lower also at P2. Conclusion: Hypertensive ESRF subjects exhibit potentiated ET-1 release on hemodialysis, possibly stimulated by volume depletion with sympathetic activation, which may attenuate hypotensive hemodialysis effects thus contributing to hypertension in ESRF.

show abstract

Section: Introductionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 95%

Effect of a Hemodialysis Session on Plasma Levels of Endothelin-1 in Hypertensive and Normotensive Subjects with End-Stage Renal Failure

Surdacki

Sułowicz

Wieczorek-Surdacka

et al. 1999

Nephron

View full text Add to dashboard Cite

show abstract

“…125 I]ET-1, human 3-[iodotyrosyl 6 -125 I]ET-3, and human 3-[iodotyrosyl 13 -125 I]BigET-1-38 were from Amersham, UK. Specific activities were approximately 2000 Ci/mmol and purity was Ͼ90%.…”

Section: Source Of Reagentsmentioning

confidence: 99%

Critical Factors in the Radioimmunoassay of Endothelin-1, Endothelin-3, and Big Endothelin-1 in Human Plasma

Shaw

Schmid

Casty

2000

Analytical Biochemistry

View full text Add to dashboard Cite

“…Dear Sir, In uremic patients, hemodialysis (HD) may change plasma endothelin 1 (ET-1) lev els [1,2], but. at present, little is known about its causes and consequences.…”

mentioning

confidence: 99%