Acute cerebral venous thrombosis

Unlock the C–N Bond Amidation of Enaminones: Metal-Free Synthesis of Enamides by Water-Assisted Transamidation

“…Eluent: V PET /V EA = 10/1; white solid (52.3 mg, 82% yield); mp 90−91 °C; 1 H NMR (400 MHz, CDCl 3 ): δ 12.86 (d,J = 10.8 Hz,1H),8.06 (t,J = 7.8 Hz,4H),7.99 (dd,J = 10.8,8.4 Hz,1H),7.75 (d,J = 8.0 Hz,2H),7.63 (t,J = 7.4 Hz,1H),7.55 (t,J = 7.6 Hz,2H),6.38 (d,J = 8.6 Hz,1H); 13 C{ 1 H} NMR (100 MHz, CDCl 3 ): δ 191. 9,165.3,141.3,141.0,133.3,131.8,129.1,128.2,128.0,125.8,125.7,100.4;19 F NMR (376 MHz,CDCl 3 ): δ −63.02; HRMS (ESI) m/z: [M + H] + calcd for C 17 H 13 F 3 NO 2 , 320.0893; found, 320.0907.…”

“…Reasonably, the synthesis of enamides itself remains a rather crucial issue in current synthetic science. As mainstream tactics, the enamides have been known to be accessible via direct addition of amides to alkynes, 7 the C−N cross coupling of amides with halo-or pseudohalo-alkenes, 8 the dehydration of N-alkyl amides, 9 addition reactions on ynamides, 10 as well as several other one-step or multistep tactics. 11 Despite the versatile modes of synthesis, one common feature of most known methods in the area is that at least one transition metal catalyst or reagent has been used.…”

Recent Developments on the Earth-Abundant-Metal-Catalyzed α,β-Dehydrogenation of Carbonyl Compounds

“…In 2023, König and Jain using tetrabutylammonium decatungstate (TBADT) as a hydrogen atom transfer agent and a cobaloxime complex as dehydrogenative agent to construct enamides from their saturated counterparts. 27 However, only a few substrates were examined, which afforded moderate product yields (Scheme 5). The triplet excited state *[W 10 O 32 ] 4abstracts a hydrogen atom from saturated substrate 41 leading to the production of alkyl radical 46 Scheme 3 Iron-catalyzed aerobic ,-dehydrogenation with an organo-cocatalyst composed of tert-butyl nitrite and N-hydroxyphthalimide…”