Acute cerebellitis in paediatric patients: Our experience

Íñiguez, J.P. García; Pisón, J. López; Revilla, P. Madurga; Gañán, I. Montejo; Cajal, M. Domínguez; Galindo, L. Monge; Marco, S.B. Sánchez; Jiménez, M.C. García

doi:10.1016/j.nrleng.2018.12.006

Cited by 10 publications

(12 citation statements)

References 23 publications

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“…Treatment modalities used reflect those in other studies and include both medical treatments such as high-dose corticosteroids, antivirals, intravenous immunoglobulin, and surgical interventions like external ventricular drainage and posterior fossa surgical decompression. 31 There is a need for guidelines for investigation and management of ACA/AC/AFC, such as those available for encephalitis. 32 This study represents cases ascertained nationally over a 6-year period across Australia, providing clinicians with an overall picture of the ACA/AC/ AFC spectrum in a post-varicella vaccine era.…”

Section: Discussionmentioning

confidence: 99%

Postinfectious Acute Cerebellar Syndromes in Children: A Nationally Ascertained Case Series From Australia 2013–2018

et al. 2022

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Introduction Postinfectious acute cerebellar syndromes show a wide spectrum of acute severity and can occur with acute febrile illness or vaccine receipt. Varicella has historically been the most common cause, associated with up to 25% of cases in large cohorts. This study aimed to describe the spectrum of syndromes in a setting with high varicella vaccine coverage. Method Data were collected on children initially identified as “suspected encephalitis” subsequently designated “not-encephalitis” at participating children's hospitals in the Paediatric Active Enhanced Disease Surveillance (PAEDS) network, Australia, as part of the Acute Childhood Encephalitis study. A comprehensive descriptive analysis was undertaken on prospectively identified, national series of children with postinfectious acute cerebellar syndromes from 2013 to 2018. Cases were classified using a previously validated severity score, and the outcome was assessed at 12 months using the Liverpool Outcome Scale score. Results A total of 20 cases (65% were vaccinated for varicella) were included, of which 70% were subcategorized as acute cerebellar ataxia (ACA), 20% acute cerebellitis (AC), and 10% acute fulminant cerebellitis (AFC). An acute febrile illness was noted in 55% and none were related to varicella or were temporally related to varicella vaccination or other childhood vaccines. A subset (total of 7 children) followed up at 12 months all showed reduced Liverpool Outcome Scale scores. Discussion The study provides an overall description of this uncommon spectrum of neurologic syndromes and shows the infrequency of varicella zoster virus as a cause in a vaccinated population.

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Section: Discussionmentioning

confidence: 99%

Postinfectious Acute Cerebellar Syndromes in Children: A Nationally Ascertained Case Series From Australia 2013–2018

et al. 2022

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“…However, cases of AC presenting with intracranial hypertension but no cerebellar symptoms have been reported occasionally and they accounted for 3/9, 5/9, and 2/15 of the total AC cases in 3 recently reported AC series. [6][7][8] The majority of cases of AC reported in the literature are attributed to postinfectious inflammation based on the fact that there is a preceding infectious disease in 92% of the cases. The median of days from preceding infectious disease to AC was 7 days.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Headache and Vomiting in an 8-Year-Old Girl

Duna

Felipe‐Rucián

Vila

et al. 2022

Clin Pediatr (Phila)

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“…Bei einem Cerebellitis-Patienten mit einem Vertikalnystagmus bei einem erhöhten intrakraniellen Duck und einer Senkung der Kleinhirntonsillen zeigte sich eine Abduzensparese [ 12 ].…”

Section: Magnetresonanztomographieuntersuchungen Als Wesentliche Diag...unclassified

Augensymptome bei Cerebellitis durch COVID-19

Schmidt

2022

Ophthalmologie

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Das Krankheitsbild der akuten Cerebellitis wurde in den letzten Jahren zunehmend beachtet. Zwei unterschiedliche Verläufe wurden beobachtet: Eine milde Verlaufsform mit leichten ataktischen Störungen (als postinfektiöse, selbstlimitierende Krankheit) und eine fulminante Verlaufsform der Cerebellitis, bei der das vergrößerte Kleinhirn den Aquaeductus Sylvii komprimiert und zu einer intrakraniellen Drucksteigerung mit einem obstruktiven Hydrozephalus und zu einer Hernienbildung der Kleinhirntonsillen im Foramen magnum führt. Dabei kann der Verlauf bei zu späten neurochirurgischen Sofortmaßnahmen letal sein. Eine Cerebellitis wurde als Folge einer Virusinfektion und durch autoimmun hervorgerufene Entzündungen beobachtet. Zahlreiche Mitteilungen befassten sich mit einer Cerebellitis bei Kindern, seltener bei Erwachsenen. An neuroophthalmologischen Befunden wurden häufig Nystagmus (horizontaler Blickrichtungsnystagmus, Vertikalnystagmus, „Down-beat“-Nystagmus, periodisch alternierender Nystagmus), Stauungspapillen, seltener Abduzens- oder Fazialisparese, Photophobie, sehr selten ein Opsoklonus-Myoklonus-Syndrom beschrieben. Wiederholt wurde eine Cerebellitis mit neuroophthalmologischen Befunden während der COVID-19-Pandemie bei Erwachsenen mitgeteilt.

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Acute cerebellitis in paediatric patients: Our experience

Cited by 10 publications

References 23 publications

Postinfectious Acute Cerebellar Syndromes in Children: A Nationally Ascertained Case Series From Australia 2013–2018

Postinfectious Acute Cerebellar Syndromes in Children: A Nationally Ascertained Case Series From Australia 2013–2018

Headache and Vomiting in an 8-Year-Old Girl

Augensymptome bei Cerebellitis durch COVID-19

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