Acute Cardiac Impairment Associated With Concurrent Chemoradiotherapy for Esophageal Cancer: Magnetic Resonance Evaluation

Reduction of heart volume during neoadjuvant chemoradiation in patients with resectable esophageal cancer

“…In contrast with our study, a previous study in 31 patients with esophageal cancer observed a decrease in left ventricle ejection fraction as measured by MRI during CRT [13]. These differences may be attributable to several factors.…”

Is cardiac toxicity a relevant issue in the radiation treatment of esophageal cancer?

“…3D functional cardiac imaging was used to evaluate cardiac toxicity in five papers [10][11][12][13][14]. Treatment details and patient numbers are again listed and marked as the last five papers in Table 1.…”

“…In a prospective study, 8 patients underwent additional ultrasound, MRI and myocardial SPECT to investigate 38 papers matching pubmed criteria 38 9 papers were excluded because of Russian, German or Japanese language 29 22 papers were excluded because they adressed radiotherapy planning issues (18), case reports (2), other toxiciƟes (1) punblished before 1980(1) 7 6 papers were included screening references from selected papers 13 13 papers were considered relevant [13]. Patients were subjected to cardiac MRIs before, during and shortly after therapy.…”

ACE inhibition attenuates radiation-induced cardiopulmonary damage

“…Although RIHT is regarded as a late side effect of radiotherapy, these recent preclinical http://dx.doi.org/10.1016/j.radonc.2014.11.017 0167-8140/Ó 2014 Elsevier Ireland Ltd. All rights reserved. and clinical [16] findings show that radiation can also affect hearts function early after irradiation, albeit without apparent clinical symptoms. As such, both lung and heart irradiation can cause pulmonary and cardiac toxicity through different mechanisms which consequentially lead to an intensified loss of cardiopulmonary performance after combined irradiation [15].…”