Acute cadmium exposure and ovarian steroidogenesis in cycling and pregnant rats

Piasek, Martina; Laskey, John W.

doi:10.1016/0890-6238(94)90032-9

Cited by 98 publications

(59 citation statements)

References 51 publications

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“…Cadmium-induced ovarian toxicity such as hemorrhagic necrosis and endothelial damage in the vessels has been reported in rats (19). In some animal studies, serum estradiol was measured as an indicator of ovarian damage in rats (20)(21)(22). A cadmium injection affected pregnancy estrogen in rats (21).…”

Section: Discussionmentioning

confidence: 99%

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Urinary Cadmium and Serum Levels of Estrogens and Androgens in Postmenopausal Japanese Women

Nagata

Nagao

Shibuya

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Recent laboratory studies have suggested that cadmium is an estrogenic compound and may be a potential risk factor for breast cancer. Methods: We investigated the relationship between urinary cadmium concentrations and serum concentrations of estrone, testosterone, and dehydroepiandrosterone sulfate in 164 postmenopausal Japanese women. Results: There was a significant positive association between the urinary cadmium and serum testosterone levels after controlling for age and body mass index. The mean testosterone level was 28% higher in women with high urinary cadmium (z z z3.00 Mg/g creatinine) than in those with

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Section: Discussionmentioning

confidence: 99%

“…In some animal studies, serum estradiol was measured as an indicator of ovarian damage in rats (20)(21)(22). A cadmium injection affected pregnancy estrogen in rats (21). Under in vitro cadmium exposure, testosterone, but not estradiol, was affected in proestrus rats (22).…”

Section: Discussionmentioning

confidence: 99%

Urinary Cadmium and Serum Levels of Estrogens and Androgens in Postmenopausal Japanese Women

Nagata

Nagao

Shibuya

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…It was shown that cadmium interfered with normal gonadal function, as a significant reduction was observed in hormonal levels in vivo (Piasek and Laskey, 1994;Paksy et al, 1997;Piasek et al, 2002;Sen Gupta et al, 2004a) as well as in vitro (Mgbonyebi et al, 1998;Piasek and Laskey, 1999;Piasek et al, 2002). Cadmium has also been shown to stimulate the synthesis of ovarian luteal progesterone at low doses; however, at high doses, the synthesis was inhibited (Henson and Chedrese, 2004).…”

Section: Introductionmentioning

confidence: 99%

Cadmium up-regulates transcription of the steroidogenic acute regulatory protein (StAR) gene through phosphorylated CREB rather than SF-1 in K28 cells

Park

Gomes

et al. 2015

J. Toxicol. Sci.

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-Cadmium is a widely used heavy metal in industry and affects the male reproductive system of animals, including humans, as a result of occupational and environmental exposures. However, the molecular mechanism underlying its effect on steroidogenesis in gonads remains unclear. In this study, we demonstrated that exposure of K28 mouse testicular Leydig tumor cells to cadmium led to a significant increase in the mRNA level, promoter activity and protein level of the steroidogenic acute regulatory protein (StAR), an essential factor for steroid biosynthesis. It has been well documented that StAR gene transcription is regulated by multiple transcription factors, including cAMP-responsive element binding protein (CREB) family members and SF-1. Cadmium treatment caused an increase in CREB phosphorylation but did not alter the CREB protein level in the nucleus. EMSA studies revealed that cadmiuminduced phosphorylated CREB formed specific complexes with the proximal region of the StAR gene promoter. Furthermore, co-transfection with a CREB expression plasmid significantly increased cadmium-induced StAR promoter activity. However, the nuclear level and the affinity of SF-1 protein for the StAR proximal promoter were dramatically decreased upon exposure to cadmium. Taken together, these results suggest that cadmium up-regulates StAR gene expression through phosphorylated CREB rather than through SF-1 in mouse testicular Leydig cells.

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“…While the biological mechanisms by which these metals may exert adverse reproductive effects have not been fully elucidated, toxicologic studies have provided some insights. Both lead and cadmium have been associated with altered steroidogenesis, decreased gonadotrophin binding and serum gonadotrophin levels in rats (Wiebe et al, 1988;Piasek and Laskey, 1994;Paksy et al, 1997;Priya et al, 2004;Nampoothiri and Gupta, 2006), and lead is associated with altered follicular growth and maturation in mice (Junaid et al, 1997). Cadmium has been shown to activate estrogen (ERa) and androgen receptors and inhibit the binding of estradiol (E 2 ) to ERa (Young et al, 1977;Garcia-Morales et al, 1994;Stoica et al, 2000;Johnson et al, 2003;Brama et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

The association between cadmium, lead and mercury blood levels and reproductive hormones among healthy, premenopausal women

et al. 2011

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background: Cadmium, lead and mercury have been identified in human follicular fluid and ovarian tissue, and have been associated with adverse reproductive outcomes in epidemiologic studies; however, few studies have examined the relationship between blood metal levels and reproductive hormones.methods: Among 252 premenopausal women aged 18-44 years, we examined the association between blood metal levels (cadmium, lead and mercury), cycle length, and reproductive hormones [FSH, LH, estradiol (E 2 ) and progesterone] measured at clinically relevant time points in the menstrual cycle. The association between metal levels (continuous) and hormone levels was assessed using linear regression with hormone levels (natural) log transformed and the results interpreted as the percentage difference in hormone level per unit increase in metal level.results: Median (interquartile range) cadmium, lead and mercury levels were 0.30 mg/l (0.19, 0.43), 0.87 mg/dl (0.68, 1.20) and 1.10 mg/l (0.58, 2.10), respectively. Each 1 mg/l increase in cadmium levels was associated with a 21% [95% confidence interval (CI): 22.9, 49.9] increase in early follicular phase E 2 levels after adjusting for age, race/ethnicity, lead and mercury. This association decreased when restricted to never smokers (10%; 95% CI: 219.5, 51.3). Cadmium was also associated with a non-significant 9% (95% CI: 20.2, 19.9), or 2.7 day, increase in cycle length among never smokers. No associations were observed between lead or mercury and the outcomes in adjusted analyses.conclusions: Further evaluation of the association between cadmium, E 2 and cycle length is warranted, taking into consideration cigarette smoke and its multiple components.

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Acute cadmium exposure and ovarian steroidogenesis in cycling and pregnant rats

Cited by 98 publications

References 51 publications

Urinary Cadmium and Serum Levels of Estrogens and Androgens in Postmenopausal Japanese Women

Urinary Cadmium and Serum Levels of Estrogens and Androgens in Postmenopausal Japanese Women

Cadmium up-regulates transcription of the steroidogenic acute regulatory protein (StAR) gene through phosphorylated CREB rather than SF-1 in K28 cells

The association between cadmium, lead and mercury blood levels and reproductive hormones among healthy, premenopausal women

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