Acute cadmium administration to rats exerts both immunosuppressive and proinflammatory effects in spleen

Demenesku, Jelena; Mirkov, Ivana; Ninkov, Marina; Aleksandrov, Aleksandra Popov; Zolotarevski, Lidija; Kataranovski, Dragan; Kataranovski, Milena

doi:10.1016/j.tox.2014.10.012

Cited by 57 publications

(33 citation statements)

References 73 publications

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“…This finding disagrees with Dwivedi and Flora [29]. Reduction of spleen weight in the current study reflects a toxic effect of As which led to an alteration of oxidative stress-related indices and complex immunemodulatory effects causing a change in the responsiveness of spleen cells to apoptosis [30].…”

Section: Discussioncontrasting

confidence: 99%

Immunotoxic and Genotoxic Effects of Arsenic and Ameliorative Potential of Quercetin and Probiotics in Wistar Rat

Alahmari¹

2017

AJLS

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Abstract:Arsenic is a significant environmental public health concern. The aim of the present study is to investigate the possible immunotoxic and genotoxic roles of arsenic and the ameliorative effects of quercetin and probiotics as natural antioxidants. This study was performed on male adult Wistar rats divided into six groups: control, NaAsO 2 -treated, quercetintreated, probiotic-treated, NaAsO 2 and quercetin-treated, and NaAsO 2 and probiotics-treated. Blood samples collected from all animals were prepared for some oxidative, immunological and genetic aspects. Administration of arsenic decreased body and spleen weight, reduced serum antioxidant defense parameters and DNA content, increased liver, kidney, and brain weights, plasma malondialdehyde (MDA), myeloperoxidase (MPO), and serum cytokines (IL-1β, IL-6, TNF-α and IFN-γ). Adding quercetin to arsenic was effective in restoring the altered values of cytokines (IL-1β and IL-6), MPO, MDA, catalase (CAT) and reduced glutathione (GSH) induced by arsenic, whereas the presence of probiotics was effective in reducing genotoxicity and improving the changes of cytokines (TNF-α and IFN-γ) and superoxide dismutase (SOD). Quercetin and probiotics are excellent antioxidant therapies, through their ability to suppress reactive oxygen species ROS production, which may contribute to arsenic toxicity.

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Section: Discussioncontrasting

confidence: 99%

Immunotoxic and Genotoxic Effects of Arsenic and Ameliorative Potential of Quercetin and Probiotics in Wistar Rat

Alahmari¹

2017

AJLS

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“…It is nonessential and known to be toxic even at low concentrations [3][4]. Both acute and chronic exposure to Cd results in damage to plants, animals, and humans, including injury to the liver, lungs, testes, renal dysfunction, anemia, osteoporosis, DNA damage, neurodegenerative diseases, intestinal damage, and immunosuppressive and pro-inflammatory effects mainly due to oxidative stress [4][5][6][7][8][9]. Many approaches have been employed to reduce cadmium toxicity, including antioxidant therapy, chelation therapy, and the use of synthetic antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Ameliorative Potential of the Aloe barbadensis Aqueous Fraction on Oxidative Stress Markers and Biochemical Parameters in Cadmium-Intoxicated Rabbits

Hussain

Chaudhry

Anjum

et al. 2016

Pol. J. Environ. Stud.

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This study was conducted to evaluate the possible protective effects of the flavonoid-rich fraction of Aloe barbadensis leaf skin on cadmium (Cd)-induced toxicity in male albino rabbits. Cadmium is a notable environmental pollutant due to its wider range of toxic manifestations. The aqueous fraction of aloe extract (AAF) showed higher phenolics, flavonoids, and antioxidant capacity among other fractions, suggesting its rationale use in this study. Twenty-four rabbits were randomly divided into four groups, including the control group (receiving only vehicle), the Cd group (receiving Cd, 5.1 mg/kg/day), the AAF groups (receiving AAF, 200 mg/Kg/day), and the Cd+AAF group (receiving the same concentrations as the Cd and AAF groups). Oral treatment over a period of 40 days significantly increased (p<0.05) biochemical marker enzymes, including transaminases (AST, ALT), alkaline phosphatase, γ-glutamyl transferase, creatinine, and urea, while total bilirubin (Tb) and albumin were decreased on days 10, 20, 30, and 40 in the Cd group as compared to control. A significant decrease (p<0.05) in enzyme levels and increases in Tb and albumin for Cd+AAF were observed as compared to Cd-treated rabbits. Contents of superoxide dismutase, catalase, and vitamins C and E in liver and kidney tissues were significantly increased (p<0.05), while cadmium content was significantly decreased (p<0.05) for Cd+AAF rabbits as compared to Cd-intoxicated rabbits. Values of all the parameters in only the AAF group were near to control. The histopathological studies for liver and kidney have also supported the Cd+AAF group markedly reducing the toxicity of Cd in both tissues to near normal. Thus, the results suggest that the flavonoid-rich fraction of AAF may

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“…Current results indicated a minor decrease in Zn and an increase in Fe between groups C and P. Nevertheless, current results did not detect any significant differences. The spleen is not a target organ for Cd toxicity; however, it accumulates Cd and suppresses both T cell and innate immunity (Demenesku et al 2014). In the exposed group P, an increase in Cd spleen concentrations was noted.…”

Section: Resultsmentioning

confidence: 99%

Can the Hyperaccumulating Plant Arabidopsis halleri in Feed Influence a Given Consumer Organism (Rattus norvegicus var. alba)?

Válek

Sloup

Jankovská

et al. 2015

Bull Environ Contam Toxicol

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Zinc and cadmium concentrations in rat (Rattus norvegicus var. alba) tissues were analyzed by inductively coupled plasma optical emission spectrometry. Rats were fed the zinc and cadmium hyperaccumulating plant, Arabidopsis halleri. When compared to the control group, a Cd increase in all tissues (liver, kidneys, small intestine, spleen, testes, muscle), with the exception of bone tissue was observed. In comparison to the control group, the kidneys, liver and small intestine contained 375, 162, and 80 times more Cd, respectively. Differences between zinc concentrations in rats fed with A. halleri and those of the control group were significant only in the small intestine and kidney tissues. Results suggest using the hyperaccumulating plant A. halleri as a feed stresses the consumer organism not through its Zn content, but through its Cd content.

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Acute cadmium administration to rats exerts both immunosuppressive and proinflammatory effects in spleen

Cited by 57 publications

References 73 publications

Immunotoxic and Genotoxic Effects of Arsenic and Ameliorative Potential of Quercetin and Probiotics in Wistar Rat

Immunotoxic and Genotoxic Effects of Arsenic and Ameliorative Potential of Quercetin and Probiotics in Wistar Rat

Investigating the Ameliorative Potential of the Aloe barbadensis Aqueous Fraction on Oxidative Stress Markers and Biochemical Parameters in Cadmium-Intoxicated Rabbits

Can the Hyperaccumulating Plant Arabidopsis halleri in Feed Influence a Given Consumer Organism (Rattus norvegicus var. alba)?

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