Acute but not chronic hyperoxia increases metabolic rate without altering the cardiorespiratory response in Atlantic salmon alevins

Polymeropoulos, Elias T.; Elliott, Nicholas; Frappell, Peter B.

doi:10.1016/j.aquaculture.2018.12.041

Cited by 7 publications

(3 citation statements)

References 37 publications

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“…The findings from one-day-old alevins, which displayed increased expression of metabolic genes after bathing, may be due to handling the stress of having increased metabolic activity. An increase in metabolic activity has been shown before when trout alevins were stressed by acute hypoxia [97].…”

Section: Metabolic Genesmentioning

confidence: 84%

Immunostimulant Bathing Influences the Expression of Immune- and Metabolic-Related Genes in Atlantic Salmon Alevins

Figueiredo

Kristoffersen

Bhat

et al. 2021

Biology

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Disease resistance of fish larvae may be improved by bath treatment in water containing immunostimulants. Pattern recognition receptors, such as TLR3, TLR7, and MDA5, work as an “early warning” to induce intracellular signaling and facilitate an antiviral response. A single bath of newly hatched larvae, with Astragalus, upregulated the expression of IFNα, IFNc, ISG15, MDA5, PKR, STAT1, TLR3, and TLR7 immune genes, on day 4 post treatment. Similar patterns were observed for Hyaluronic acid and Poly I:C. Increased expression was observed for ISG15, MDA5, MX, STAT1, TLR3, TLR7, and RSAD2, on day 9 for Imiquimod. Metabolic gene expression was stimulated on day 1 after immunostimulant bath in ULK1, MYC, SLC2A1, HIF1A, MTOR, and SIX1, in Astragalus, Hyaluronic acid, and Imiquimod. Expression of NOS2 in Poly I:C was an average fourfold above that of control at the same timepoint. Throughout the remaining sampling days (2, 4, 9, 16, 32, and 45 days post immunostimulant bath), NOS2 and IL1B were consistently overexpressed. In conclusion, the immunostimulants induced antiviral gene responses, indicating that a single bath at an early life stage could enable a more robust antiviral defense in fish. Additionally, it was demonstrated, based on gene expression data, that cell metabolism was perturbed, where several metabolic genes were co-regulated with innate antiviral genes.

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Section: Metabolic Genesmentioning

confidence: 84%

Immunostimulant Bathing Influences the Expression of Immune- and Metabolic-Related Genes in Atlantic Salmon Alevins

Figueiredo

Kristoffersen

Bhat

et al. 2021

Biology

View full text Add to dashboard Cite

show abstract

“…growth [2]). It is owing to this ecological relevance as well as potential benefits in aquaculture that efforts have intensified to unravel the physiological impacts of hyperoxia in fish [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of enhanced cardiorespiratory performance under hyperoxia differ with exposure duration in yellowtail kingfish

Morgenroth,

McArley,

Khan

et al. 2024

Proc. R. Soc. B.

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Hyperoxia has been shown to expand the aerobic capacity of some fishes, although there have been very few studies examining the underlying mechanisms and how they vary across different exposure durations. Here, we investigated the cardiorespiratory function of yellowtail kingfish ( Seriola lalandi ) acutely (~20 h) and chronically (3–5 weeks) acclimated to hyperoxia (~200% air saturation). Our results show that the aerobic performance of kingfish is limited in normoxia and increases with environmental hyperoxia. The aerobic scope was elevated in both hyperoxia treatments driven by a ~33% increase in maximum O 2 uptake (MO 2max ), although the mechanisms differed across treatments. Fish acutely transferred to hyperoxia primarily elevated tissue O 2 extraction, while increased stroke volume-mediated maximum cardiac output was the main driving factor in chronically acclimated fish. Still, an improved O 2 delivery to the heart in chronic hyperoxia was not the only explanatory factor as such. Here, maximum cardiac output only increased in chronic hyperoxia compared with normoxia when plastic ventricular growth occurred, as increased stroke volume was partly enabled by an ~8%–12% larger relative ventricular mass. Our findings suggest that hyperoxia may be used long term to boost cardiorespiratory function potentially rendering fish more resilient to metabolically challenging events and stages in their life cycle.

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“…When compared to normoxia, hyperoxia had similar but less effective influences, with weight gain and decreasing in growth rate and increasing in feed conversion ratio, but all of these differences were less than hypoxia (Aksakal and Ekinci, 2021) [27] . The long-term implications of hyperoxia are still unknown (Polymeropoulos et al, 2019) [28] .…”

Section: Introductionmentioning

confidence: 99%

Effects of dissolved oxygen concentration on freshwater fish: A review

Ali¹,

Anushka²,

Mishra³

2022

Int. J. Fish. Aquat. Stud.

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Dissolved Oxygen (DO) is one of the most important factors for aquatic animals as especially for those who derive dissolved oxygen from the water. DO levels indicate the quality of water. Many biotic and abiotic factors may influence DO concentration like mixing of different water bodies, upwelling, atmospheric exchange, respiration, photosynthesis, ice cover, pollution and some physical factors like salinity and temperature. The fluctuations in DO levels in water affect fish physiology. In this review, we will focus on the impact of DO on freshwater fish-physiology. A detailed literature survey is given based on DO and freshwater fish swimming, feeding, disease management, survival, respiration, metabolism, growth, reproduction, health parameters, immunity and stress of freshwater fishes.

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Acute but not chronic hyperoxia increases metabolic rate without altering the cardiorespiratory response in Atlantic salmon alevins

Cited by 7 publications

References 37 publications

Immunostimulant Bathing Influences the Expression of Immune- and Metabolic-Related Genes in Atlantic Salmon Alevins

Immunostimulant Bathing Influences the Expression of Immune- and Metabolic-Related Genes in Atlantic Salmon Alevins

Mechanisms of enhanced cardiorespiratory performance under hyperoxia differ with exposure duration in yellowtail kingfish

Effects of dissolved oxygen concentration on freshwater fish: A review

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