Acute bronchiolitis

Bush, Andrew; Thomson, Anne

doi:10.1136/bmj.39374.600081.ad

Cited by 75 publications

(86 citation statements)

References 17 publications

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“…Even if there is no exact evidence for administration of nebulized epinephrine to infants with a diagnosis of AB; according to AAP guidelines, more studies are needed to consider for treatment of outpatients 6 . Multiple comparisons of symptomatic therapies in varying doses have been undertaken and outcomes have varied widely even within the same country [10][11][12][13][14] . There is no agreed therapeutic standard of care worldwide.…”

mentioning

confidence: 99%

Rational drug use for acute bronchiolitis in emergency care

Uysalol¹,

Haşlak²,

Özünal³

et al. 2017

Turk J Pediatr

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Despite the large variety of inhaled treatment options of acute bronchiolitis, there is no generally agreed treatment regime. This study aimed to determine the most appropriate treatment option. This was a double-blind randomized prospective clinical trial and has been performed in emergency department. The mean age of the 378 infants included in the study was 7.63 ± 4.6 months, and 54.8% (207) were boys. Patients were randomized by using the lottery method for simple random sample into 5 different treatment options; 3% hypertonic saline, nebulized adrenaline, nebulized adrenaline mixed with 3% hypertonic saline, nebulized salbutamol, and as control group; normal saline (0.9% NaCl). From the first treatment time until discharge time; treatment durations, adverse events and readmission rates within the first fifteen days were recorded for each patient. Nebulized adrenaline mixed with 3% hypertonic saline, as compared with other options, were associated with a significantly higher discharge rate at 4 th hours (p<0.001) and shorter length of hospital stay (p=0.039). However, there was no significant difference between options with regard to adverse events, discharge rates at 24 th hours, and readmission rates within the first fifteen days. The superiority of discharge rates at 4 hours of nebulized adrenaline mixed with 3% hypertonic saline, was evaluated as 'better acute response' and can be helpful to reduce hospitalization needs. Additionally, this option seems to be more effective to reduce length of hospital stay.

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mentioning

confidence: 99%

Rational drug use for acute bronchiolitis in emergency care

Uysalol¹,

Haşlak²,

Özünal³

et al. 2017

Turk J Pediatr

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“…3,4 In addition, practitioners are not unanimous on certain aspects of its management, particularly in prescription drugs used for aerosol; some authors claim that bronchodilators are not effective in bronchiolitis; other studies have shown that β2 mimetics are effective especially after the age of six months and if the child has already had episodes of wheezing dyspnea or history of personal or familial atopy. [5][6][7] Other authors have reported the efficiency of nebulized epinephrine and more recent studies have shown that nebulization of isotonic saline and hypertonic saline at 3% seems to be more effective than β2mimetics and epinephrine.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the efficiency of the nebulization of salbutamol, epinephrine and normal saline on treatment of bronchiolitis

et al. 2016

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“…Although <2% of infants with bronchiolitis require hospital admission, RSV is responsible for up to 75% of the hospitalizations for severe bronchiolitis in infants aged <1 year [2,4,6].…”

Section: Introductionmentioning

confidence: 99%

Respiratory morbidity of preterm infants of less than 33 weeks gestation without bronchopulmonary dysplasia: a 12-month follow-up of the CASTOR study cohort

et al. 2013

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SUMMARYThe aim of this study was to describe the incidence and risk factors for respiratory morbidity during the 12-month period following the first respiratory syncytial virus (RSV) season in 242 preterm infants [<33 weeks gestational age (GA)] without bronchopulmonary dysplasia and 201 full-term infants (39-41 weeks GA) from the French CASTOR study cohort. Preterm infants had increased respiratory morbidity during the follow-up period compared to full-terms; they were more likely to have wheezing (21% vs. 11%, P = 0·007) and recurrent wheezing episodes (4% vs. 1%, P = 0·049). The 17 infants (14 preterms, three full-terms) who had been hospitalized for RSV-confirmed bronchiolitis during their first RSV season had significantly more wheezing episodes during the follow-up period than subjects who had not been hospitalized for RSVconfirmed bronchiolitis (odds ratio 4·72, 95% confidence interval 1·71-13·08, P = 0·003). Male gender, birth weight <3330 g and hospitalization for RSV bronchiolitis during the infant's first RSV season were independent risk factors for the development of wheezing episodes during the subsequent 12-month follow-up period.

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Acute bronchiolitis

Cited by 75 publications

References 17 publications

Rational drug use for acute bronchiolitis in emergency care

Rational drug use for acute bronchiolitis in emergency care

Comparison of the efficiency of the nebulization of salbutamol, epinephrine and normal saline on treatment of bronchiolitis

Respiratory morbidity of preterm infants of less than 33 weeks gestation without bronchopulmonary dysplasia: a 12-month follow-up of the CASTOR study cohort

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