Acute Brainstem Auditory Evoked Potential Abnormalities in Jaundiced Gunn Rats Given Sulfonamide

Shapiro, Steven M.

doi:10.1203/00006450-198803000-00015

Cited by 51 publications

(56 citation statements)

References 19 publications

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“…22 Notably, several studies have shown that hyperbilirubinemia-associated abnormalities in brainstem auditory evoked responses may be reversible with treatment of hyperbilirubinemia. 11,[22][23][24] We were unable to assess for ANSD in the present study because only a small number of participants had auditory nerve testing performed (most were tested with audiograms at their audiology visits).…”

Section: Discussionmentioning

confidence: 99%

Risk of Sensorineural Hearing Loss and Bilirubin Exchange Transfusion Thresholds

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Risk of Sensorineural Hearing Loss and Bilirubin Exchange Transfusion Thresholds

et al. 2015

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“…14,15 When infant jaundiced Gunn rats are given a sulfonamide to displace bilirubin from blood (albumin) into brain tissue, 16 there were acute increases in interwave intervals and decreases in amplitudes of ABR waves II and III, which correspond to waves III and V of the human, respectively. 17 These changes occur within an hour or two after toxicity, sometimes within minutes, and are reversible. 18 In more severely affected rats, the response from the auditory nerve, wave I, is affected.…”

Section: Localization Of Abnormalities In the Auditory System Neuroanmentioning

confidence: 99%

Bilirubin and the Auditory System

2001

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“…In the current study, we calculated in vivo CNS B F levels in Gunn rat pups during peak hyperbilirubinemia (postnatal d [15][16][17][18][19] (3,4) to assess how calculated in vivo B F levels compare with reported calculated in vitro B F toxic thresholds. The Gunn rat (5) offers an intriguing model to explore this matter as this animal spontaneously develops newborn jaundice differing from others that rely on artificial means of inducing hyperbilirubinemia (6).…”

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Calculated In Vivo Free Bilirubin Levels in the Central Nervous System of Gunn Rat Pups

Daood

Watchko

2006

Pediatr Res

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ABSTRACT:In vitro studies suggest a free bilirubin (B F ) concentration in the range of 71-770 nmol/L can induce neurotoxicity. In vivo data regarding central nervous system (CNS) B F levels have not been determined. We calculated in vivo CNS B F levels in Gunn rat pups (15-19 d old; heterozygous nonjaundiced Gunn rats (J/j) and homozygous jaundiced Gunn rats (j/j); saline or sulfadimethoxine treated) based on 1) total brain bilirubin (TBB) content, 2) brain albumin level, 3) CNS bilirubin binding capacity attributable to brain albumin determined using an ultrafiltration technique, and 4) published Gunn rat albumin-bilirubin binding constants (k). Gunn rat brain bilirubin binding capacity was ϳ22 ϫ 10 Ϫ3 mol/g, of which two thirds was accounted for by brain albumin. Using a Gunn rat pup in vivo, k of 9.2 L/mol, calculated CNS B F levels ranged from 72 to 112 nmol/L [95% confidence interval (CI)] in saline and from 59 to 156 nmol/L (95% CI) in sulfadimethoxine-treated J/j pups. These animals demonstrated no neurobehavioral abnormalities and normal cerebellar weight. Calculated CNS B F levels were severalfold higher (p Ͻ 0.001) in saline (95% CI: 556 -1110 nmol/L) and sulfadimethoxine-treated (95% CI: 3461-8985 nmol/L) j/j pups; the former evidenced reduced cerebellar weight; the latter both reduced cerebellar weight and acute neurobehavioral abnormalities. We conclude that calculated CNS B F values in j/j pups are substantially higher than those in J/j animals. Given the absence of CNS abnormalities in J/j pups, the presence of such in j/j animals, and the CNS B F levels in these groups, we speculate that the CNS B F neurotoxicity threshold in vivo is subsumed within the range (71-770 nmol/L) reported in vitro. (Pediatr Res 60: 44-49, 2006)

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Acute Brainstem Auditory Evoked Potential Abnormalities in Jaundiced Gunn Rats Given Sulfonamide

Cited by 51 publications

References 19 publications

Risk of Sensorineural Hearing Loss and Bilirubin Exchange Transfusion Thresholds

Risk of Sensorineural Hearing Loss and Bilirubin Exchange Transfusion Thresholds

Bilirubin and the Auditory System

Calculated In Vivo Free Bilirubin Levels in the Central Nervous System of Gunn Rat Pups

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