Acute brain reaction to DBS electrodes after deep brain stimulation: chronological observation

Abstract

We report here our chronological observations of acute brain reactions after DBS procedures, which we believe are neither infectious nor vascular, but are possibly caused by the mechanical breakdown of the blood-brain barrier by microelectrode recordings or by anchored DBS electrodes. These lesions are thought to constitute a self-limiting disorder requiring no further treatment.

Peri‐lead edema after deep brain stimulation surgery for Parkinson's disease: a prospective magnetic resonance imaging study

“…The approximate incidence of this finding was of 0.4% and thus the authors defined it as a rare complication. In past years other authors have described radiological findings consistent with peri-electrode edema in patients following DBS lead placement [2][3][4][5][6][7][8][9][10][11][12][13]. The literature indicates an extremely wide range from 0.4% [10] to 39% [2] for this complication.…”

“…In past years other authors have described radiological findings consistent with peri‐electrode edema in patients following DBS lead placement . The literature indicates an extremely wide range from 0.4% to 39% for this complication.…”

“…The most frequently reported complications include hemorrhage, infection and hardware failure [1]. In recent years, non-infectious, delayed-onset post-operative cerebral edema around DBS electrodes has been reported as a rare complication of DBS surgery by different groups worldwide [2][3][4][5][6][7][8][9][10][11][12][13]. According to the literature, its incidence ranges from 0.4% [10] to 39% [2], but methods for its detection are heterogeneous, including studies of computed tomography (CT) and magnetic resonance imaging (MRI) performed only in selected patients and at different time intervals after surgery.…”

“…According to the literature, its incidence ranges from 0.4% [10] to 39% [2], but methods for its detection are heterogeneous, including studies of computed tomography (CT) and magnetic resonance imaging (MRI) performed only in selected patients and at different time intervals after surgery. Most studies report post-operative edema as a symptomatic complication [3,[5][6][7][8][9][10][11]13], whereas others find it accidentally during routine imaging in asymptomatic patients [2,4,12]. The true prevalence of this entity is still unknown as no control MRI is routinely performed in the days after DBS surgery.…”

Cystic Lesions as a Rare Complication of Deep Brain Stimulation

“…These investigators suggested that the cause of cyst formation was tracked CSF during placement of the DBS lead or, alternatively, because of an autoimmune or inflammatory response to the DBS hardware. 4,5 Acute brain parenchymal reaction resulting from lead insertion has been suggested as a mechanism for rare findings of low-attenuation signal around the DBS lead after surgery by Kim et al 6 They described 7 cases of transient increased lowattenuation signals that circumferentially surrounded DBS electrodes. The signal extended into the subcortical white matter and was associated with unexpected and transient neurological symptoms during the immediate postoperative period.…”