Acute Bilateral Anterior Uveitis following Cyclophosphamide/ Bortezomid/ Dexamethasone (CyBorD) Protocol in a Newly Diagnosed Multiple Myeloma Patient with Concomitant Use of Zoledronic Acid

Karmiris, Efthymios; Vasilopoulou, Maria-Giannoula; Chalkiadaki, Evangelia

doi:10.1080/09273948.2020.1745245

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…The obtained substances may prove useful in the development of new pharmaceutically active substances [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ] and may be synthesized by the Ugi reaction ( Figure 1 ). Examples include protease inhibitors (Telaprevir, Crixivan, Indavir—against HIV) or kainic anesthetics (lidocaine, bupivacaine) [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. They can be used successfully in the treatment of bacterial infections, viral diseases, cardiovascular diseases, diabetes, osteoporosis, and neoplasms, with the use of calpain inhibitors and the proteasome-inhibiting drug Bortezomib ( Figure 1 ) [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ,…”

Section: Introductionmentioning

confidence: 99%

“…However, there are some disadvantages to using peptides and protein fragments as therapeutic agents related to the rapid degradation of peptides by proteases or lipases present in the cell [ 1 , 2 , 3 , 4 ]. According to the literature, slight chemical modifications of Ugi adducts indicate a huge biological difference in their formation and biological activity [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ].…”

Section: Introductionmentioning

confidence: 99%

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α-Amidoamids as New Replacements of Antibiotics—Research on the Chosen K12, R2–R4 E. coli Strains

et al. 2020

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A preliminary study of α-amidoamids as new potential antimicrobial drugs was performed. Special emphasis was placed on selection of structure of α-amidoamids with the highest biological activity against different types of Gram-stained bacteria by lipopolysaccharide (LPS). Herein, Escherichia coli model strains K12 (without LPS in its structure) and R1–R4 (with different length LPS in its structure) were used. The presented work showed that the antibacterial activity of α-amidoamids depends on their structure and affects the LPS of bacteria. Moreover, the influence of various newly synthesized α-amidoamids on bacteria possessing smooth and rought LPS and oxidative damage of plasmid DNA caused by all newly obtained compounds was indicated. The presented studies clearly explain that α-amidoamids can be used as substitutes for antibiotics. The chemical and biological activity of the analysed α-amidoamids was associated with short alkyl chain and different isocyanides molecules in their structure such as: tetr-butyl isocyanide or 2,5-dimethoxybenzyl isocyanide. The observed results are especially important in the case of the increasing resistance of bacteria to various drugs and antibiotics.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

α-Amidoamids as New Replacements of Antibiotics—Research on the Chosen K12, R2–R4 E. coli Strains

et al. 2020

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“…Cycloplegics are indicated for anterior uveitis [38 & ]. There are conflicting data on rechallenge with the same bisphosphonate; some reports indicate recurrence of symptoms while others do not [45,46]. Use of a different bisphosphonate or pretreatment with topical corticosteroid drops may also be adequate [47,48].…”

Section: Bisphosphonatesmentioning

confidence: 99%

Ocular involvement in allergic drug reactions

Fernandez

Phillips

Saeed

2023

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review Many systemic medications have been observed to cause ocular toxicity. A subset of these reactions is thought to involve immunomodulation or a hypersensitivity reaction. As new medications are developed, ocular adverse effects are becoming increasingly prevalent. Herein we review immune-mediated drug reactions affecting they eye with special attention to the hypersensitivity mechanisms leading to ocular toxicity. Recent findings Recent work has focused on mechanisms and risk of immune-mediated ocular adverse drug reactions including genetic susceptibility and loss of ocular immune privilege. Summary Given the consequences of immune-mediated ocular adverse drug reactions, clinicians must be aware of these to facilitate early recognition and management. The prompt involvement of an ophthalmologist for diagnosis and management is often essential to preserve vision and avoid long-term morbidity.

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Cyclopentolate/zoledronic-acid

2023

Reactions Weekly

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Acute Bilateral Anterior Uveitis following Cyclophosphamide/ Bortezomid/ Dexamethasone (CyBorD) Protocol in a Newly Diagnosed Multiple Myeloma Patient with Concomitant Use of Zoledronic Acid

Cited by 5 publications

References 6 publications

α-Amidoamids as New Replacements of Antibiotics—Research on the Chosen K12, R2–R4 E. coli Strains

α-Amidoamids as New Replacements of Antibiotics—Research on the Chosen K12, R2–R4 E. coli Strains

Ocular involvement in allergic drug reactions

Cyclopentolate/zoledronic-acid

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