Acute bacterial meningitis: an analysis of factors influencing prognosis

Hodges, Glenn R.; Perkins, Robert L.

doi:10.1097/00000441-197511000-00003

Cited by 85 publications

(36 citation statements)

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“…However, even this is not absolutely reliable since it was also observed in two of the pneumococcal patients and one of the haemophilus patients. Petechial rashes in patients from these latter groups have been reported by other authors (Carpenter & Petersdorf, 1962;Hodges & Perkins, 1975;Jensen, Ranek & Rosdahl, 1969;Johnsson & Alvin, 1971;Laxer & Marks, 1977).…”

Section: Clinical Presentationsupporting

confidence: 66%

“…Meningitis due to uncommon organisms is much less frequent in our series than in comparable North American series (Carpenter & Petersdorf, 1962;Eigler et al 1961;Hodges & Perkins, 1975) (Table 2). In a community-based study of bacterial meningitis in Olmsted County, U.S.A. from 1935-79, Fraser, et al reported a trebling of disease due to unusual organisms when the years 1935-46 were compared with 1959-70 (Fraser, Henke & Feldman, 1973).…”

Section: Outcome -Pneumococcal Groupcontrasting

confidence: 39%

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Bacterial meningitis – ten years experience

Davey¹,

Cruikshank²,

McManus

et al. 1982

J. Hyg.

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SummaryBetween January 1968 and December 1977, 635 cases of acute bacterial meningitis were admitted to hospitals in the Birmingham Area Health Authority. The epidemiology of these cases was analysed and compared with the 270 cases which were admitted to the regional infectious diseases unit at East Birmingham Hospital (E.B.H.). In children and young adults the meningococcus was the commonest causative organism while over the age of 25 pneumococcal meningitis predominated. AlthoughHaemophilus influenzaewas the second commonest infecting organism it was a rare cause of meningitis in school children and adults, only four cases presenting in these age groups in the Birmingham Area.A detailed analysis was made of the symptoms, signs, laboratory investigations and clinical course of the 270 cases treated at E.B.H.The mortality in the patients with pneumococcal meningitis was 30%. In the meningococcal group it was 3·5% and in the haemophilus groups 7·7%.An analysis of the various treatment regimes employed in the 270 E.B.H. patients supports the view that a single antibiotic is sufficient for the therapy of most forms of bacterial meningitis. Intrathecal antibiotic administration is unnecessary in pyogenic meningitis caused by meningococci, pneumococci orH. influenzae.

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Section: Clinical Presentationsupporting

confidence: 66%

Section: Outcome -Pneumococcal Groupcontrasting

confidence: 39%

Bacterial meningitis – ten years experience

Davey¹,

Cruikshank²,

McManus

et al. 1982

J. Hyg.

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“…Fifty rabbits were divided into four groups: normal uninfected, normal infected, neutropenic uninfected, and neutropenic infected. On the day of the experiments, neutropenic rabbits had peripheral WBC counts of 550 ± 350/mm, 3 compared with 6500 ± 2020 WBCs/mm 3 in normal rabbits (P < .001). In neutropenic rabbits, granulocytes consistently accounted for <10% of the peripheral WBCs, compared with 35.2% ± 14.4% in normal rabbits (P < .001).…”

Section: Resultsmentioning

confidence: 92%

“…Morbidity and mortality from bacterial meningitis remain high [1][2][3][4]. Pneumococcal meningitis has, even in recent years, a death rate of almost 30070 [3,4].…”

mentioning

confidence: 99%

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Influence of Granulocytes on Brain Edema, Intracranial Pressure, and Cerebrospinal Fluid Concentrations of Lactate and Protein in Experimental Meningitis

Täuber

Borschberg²,

Sande³

1988

Journal of Infectious Diseases

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Brain water content (brain edema), intracranial pressure, and cerebrospinal fluid (CSF) concentrations of lactate and protein increased significantly during 24 h of experimental meningitis due to Streptococcus pneumoniae, but changes were similar in normal and neutropenic rabbits. In sterile meningitis induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP), low and high doses of fMLP were equally effective in inducing CSF pleocytosis, whereas only high doses of fMLP caused brain edema. High doses of fMLP injected intracisternally during pneumococcal meningitis also increased brain water content. The fMLP did not significantly increase intracranial pressure or CSF concentrations of lactate or protein in sterile or pneumococcal meningitis, nor did it cause brain edema in neutropenic animals. Thus, granulocytes may contribute to brain edema during meningitis if adequately stimulated, but intracranial pressure and CSF protein and lactate concentrations appear independent of granulocytes. Stimulation does not appear to occur early in meningitis, when granulocytes were without effect on brain edema.

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