Acute Atrophy of Bone (Osteoporosis) Simulating Hyperparathyroidism12

Albright, Fuller; Burnett, Charles H.; Cope, Oliver; Parson, Walther

doi:10.1210/jcem-1-9-711

Cited by 188 publications

(52 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4 The classic description of hypercalcemia complicating the immobilization of a patient without pre-existing metabolic bone disease was by Albright et al, 2 and he named the condition acute bone atrophy, as cited by Winters et al 5 Albright et al 2 also hypothesized that the skeletal structure during normal activity is subjected to manifold stresses and hormonal and nutritional influences. The balance of these factors maintains a steady state between bone formation and destruction.…”

Section: Discussionmentioning

confidence: 99%

“…1 However, these conditions are occasionally severe, producing a variety of symptoms, including seizures and respiratory arrest. 1 The first reported case of hypercalcemia due to immobilization was by Albright et al 2 in 1941. The patient was subjected to an array of investigations and treatment including parathyroidectomy before the diagnosis was made, as cited by Conley et al 1 Accident and injuries are major public health problems worldwide.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Determinants of hypercalcemia and hypercalciuria in immobilized trauma patients

et al. 2015

View full text Add to dashboard Cite

Hypercalcemia and hypercalciuria secondary to immobilization can be occasionally severe, producing an array of symptoms. This study looked at possible determinants of hypercalcemia and hypercalciuria in immobilized trauma patients. This is a prospective observational study carried out over a period of 7 months. Fifty-five immobilized trauma patients were evaluated weekly for 4 weeks for symptoms of hypercalcemia, total serum calcium and 24-h urinary calcium. The number of limbs immobilized had a significant relationship with hypercalcemia at the end of week 1 (Po0.001) and week 4 (P ¼ 0.008) and with hypercalciuria at the end of week 1 only (Po0.001). The number of bones fractured also had a significant relationship with hypercalcemia at the end of week 1 (P ¼ 0.005) and week 4 (P ¼ 0.019), as well as with hypercalciuria at the end of week 1 (Po0.001) and week 2 (P ¼ 0.036). Weight loss was significantly associated with hypercalcemia at the end of week 4 (P ¼ 0.014) and with hypercalciuria at the end of week 3 (Po0.001) and week 4 (Po0.001), whereas polyuria and polydipsia had a significant association with hypercalciuria at the end of week 2 (Po0.001) and week 3 (P ¼ 0.030). The number of limbs immobilized and bones fractured showed an early significant relationship with the development of hypercalcemia and hypercalciuria. Weight loss showed late association with hypercalcemia and hypercalciuria, whereas polyuria and polydipsia showed early association with hypercalciuria.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determinants of hypercalcemia and hypercalciuria in immobilized trauma patients

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Albright questioned whether the tu- mor might be responsible for ectopic production of parathyroid hormone. In the same year, Albright described a case of hypercalcemia in a 14 yr old boy who fractured his femur through a bone cyst in an athletic accident (12). After casting and bed rest, the patient developed severe hypercalcemia.…”

Section: Mineral Metabolismmentioning

confidence: 99%

Fuller Albright

Levine

Felsenfeld

2009

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

“…The impetus behind the next 40+ years of bone research in space may have come in the 1940's when the premier endocrinologist, Fuller Albright, called attention to the disturbed calcium metabolism evident in a young patient experiencing prolonged bed rest [1]. This was subsequently proven by Whedon and colleagues in studies demonstrating that musculoskeletal atrophy was due to the mechanical unloading of prolonged bed rest and not disease per se [2].…”

Section: Introductionmentioning

confidence: 99%

Adaptation of the Skeletal System During Long-Duration Spaceflight

Sibonga

Cavanagh

Lang

et al. 2007

Clinic Rev Bone Miner Metab

View full text Add to dashboard Cite

This review will highlight evidence from crew members flown on space missions >90 days to suggest that the adaptations of the skeletal system to mechanical unloading may predispose crew members to an accelerated onset of osteoporosis after return to Earth. By definition, osteoporosis is a skeletal disorder − characterized by low bone mineral density and structural deterioration − that reduces the ability of bones to resist fracture under the loading of normal daily activities. "Involutional" or agerelated osteoporosis is readily recognized as a syndrome afflicting the elderly population because of the insipid and asymptomatic nature of bone loss that does not typically manifest as fractures until after age 1 https://ntrs.nasa.gov/search.jsp?R=20080014098 2018-05-10T03:42:55+00:00Z ~60. It is not the thesis of this review to suggest that spaceflight-induced bone loss is similar to bone loss induced by metabolic bone disease; rather this review draws parallels between the rapid and earlier loss in females that occurs with menopause and the rapid bone loss in middle-aged crew members that occurs with spaceflight unloading and how the cumulative effects of spaceflight and ageing could be detrimental, particularly if skeletal effects are totally or partially irreversible.In brief, this report will provide detailed evidence that long-duration crew members, exposed to the weightlessness of space for the typical long-duration (4-6 months) mission on Mir or the International Space Station --1. Display bone resorption that is aggressive, that targets normally weight-bearing skeletal sites, that is uncoupled to bone formation and that results in areal BMD deficits that can range between 6-20% of preflight BMD; 2. Display compartment-specific declines in volumetric BMD in the proximal femur (a skeletal site of clinical interest) that significantly reduces its compressive and bending strength and which may account for the loss in hip bone strength (i.e., force to failure); 3. Recover BMD over a post-flight time period that exceeds spaceflight exposure but for which the restoration of whole bone strength remains an open issue and may involve structural alteration; and 4. Display risk factors for bone loss --such as the negative calcium balance and down-regulated calcium-regulating hormones in response to bone atrophy --that can be compounded by the constraints of conducting mission operations (inability to provide essential nutrients and vitamins).The full characterization of the skeletal response to mechanical unloading in space is not complete. In particular, countermeasures used to date have been inadequate and it is not yet known 2 whether more appropriate countermeasures can prevent the changes in bone that have been found in previous flights, Knowledge gaps related to the effects of prolonged (> 6months) space exposure and to partial gravity environments are substantial, and longitudinal measurements on crew members after spaceflight are required to assess the full impact on skeletal recovery.

show abstract

Acute Atrophy of Bone (Osteoporosis) Simulating Hyperparathyroidism12

Cited by 188 publications

References 0 publications

Determinants of hypercalcemia and hypercalciuria in immobilized trauma patients

Determinants of hypercalcemia and hypercalciuria in immobilized trauma patients

Fuller Albright

Adaptation of the Skeletal System During Long-Duration Spaceflight

Contact Info

Product

Resources

About