2018
DOI: 10.1097/md.0000000000009794
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Acute appendicitis complicated with necrotizing fasciitis in a patient with adult-onset Still's disease

Abstract: Rationale:Adult-onset Still disease (AOSD) is a rare systemic inflammatory disease of unknown etiology characterized by evanescent salmon-pink rash, spiking fever, arthralgia/ arthritis, and lymphadenopathy. AOSD sometimes was fatal when it is complicated by macrophage activation syndrome (MAS) or hemophagocytic lymphohistiocytosis (HLH). Nonetheless, the literature provides no recommendations for treatment of AOSD patients with severe sepsis.Patient concerns:A previously healthy 65-year-old man with history o… Show more

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Cited by 7 publications
(9 citation statements)
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“…Prior to the well referenced description of "perforating inflammation of the vermiform appendix" by Dr. Reginald Fitz in 1886, surgeons had been extirpating the appendix and discovering the evolution of appendicitis as a clinical disease process (9). The first surgeon on record, Claudius Amyand, eponymous for Amyand's hernia (an appendix identified within a hernia sac) identified an inflamed appendix in an inguinal hernia of a young boy in 1736 (10).…”
Section: Evolution Of Surgical Management Of Appendicitismentioning
confidence: 99%
“…Prior to the well referenced description of "perforating inflammation of the vermiform appendix" by Dr. Reginald Fitz in 1886, surgeons had been extirpating the appendix and discovering the evolution of appendicitis as a clinical disease process (9). The first surgeon on record, Claudius Amyand, eponymous for Amyand's hernia (an appendix identified within a hernia sac) identified an inflamed appendix in an inguinal hernia of a young boy in 1736 (10).…”
Section: Evolution Of Surgical Management Of Appendicitismentioning
confidence: 99%
“…8 Although wide‐spectrum antibiotic treatment is thought to be a safe management plan in treating appendicitis, it has a 7% failure rate, most commonly seen in immunosuppressed patients who mainly use corticosteroids. 9 …”
Section: Introductionmentioning
confidence: 99%
“…The disease is mainly observed in immunodeficient patients, in whom the mortality rate can be up to 30%. 4 , 8 , 9 Adult NF occurs more frequently in the abdomen, perineum, and limbs, but in children, especially infants, it usually occurs in the trunk. 13 NF in infants after acute appendicitis is rare and fatal, but exceptions have also been reported, which require prompt diagnosis with aggressive medical and surgical interventions.…”
Section: Introductionmentioning
confidence: 99%
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“…Moreover, it alone carries a 13.6% mortality [1]. On the other hand, a complicated perorated appendix with necrotizing fasciitis has a higher mortality rate, reaching 30-38% [8]. Early aggressive surgical debridement after diagnosis must take place to avoid systemic sepsis and enhance patient survival [1].…”
Section: Introductionmentioning
confidence: 99%