Acute Anuric Renal Failure in Nonfulminant Hepatitis A Infection

Jamil, Shazia; Massry, Shaul G.

doi:10.1159/000013360

Cited by 15 publications

(3 citation statements)

References 12 publications

(11 reference statements)

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“…[8][9][10][11][12][13][14][15][16][17][18] However, recent studies in Korea have suggested that AKI is not a rare complication having incidence rate from 3% up to 7.2%. [2][3][4][5] In this study, the rates of AKI were 7.6% in whole hepatitis A cases, and 5.8% in nonfulminant cases.…”

Section: Discussionmentioning

confidence: 99%

Clinical features and outcomes of acute kidney injury among patients with acute hepatitis A

Choi

Song

Han

et al. 2011

Journal of Clinical Virology

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Section: Discussionmentioning

confidence: 99%

Clinical features and outcomes of acute kidney injury among patients with acute hepatitis A

Choi

Song

Han

et al. 2011

Journal of Clinical Virology

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“…This lesion is essentially due to direct cytotoxic actions of Correlation between bilirubin and creatinine levels in patients treated by dialysis or not. Updated graph according to Faust et al [3] with additional cases [1,2,4,6] and the present observation intrarenal accumulated bilirubin and bile salts [7]. Immune complex glomerulonephritis cannot be excluded as etiologic factor or cofactor of renal injury in our patient but the absence of proteinuria and hematuria are strong reasons against an active glomerular process.…”

Section: Discussionmentioning

confidence: 58%

Cholestatic hepatitis A complicated by acute renal insufficiency

Wolf

Oneta²,

Jornod³

et al. 2001

Z Gastroenterol

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31 cases of non-fulminant hepatitis A complicated by acute renal insufficiency are reported in the literature. Two-thirds of those patients needed dialysis, usually when depending on the severity of their hyperbilirubinemia. This report concerns the first published case of non-fulminant cholestatic hepatitis A complicated by acute renal insufficiency in which a spontaneous remission of renal function occurred without need for dialysis despite a very severe hyperbilirubinemia.

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“…The mechanism of AHA‐associated ARF is uncertain. However, several pathogenic mechanisms such as glomerulonephritis, acute tubular necrosis and HRS have been implicated [15]. The various pathological findings of AHA‐associated ARF suggest a variety of mechanisms that may be associated with ARF.…”

Section: Discussionmentioning

confidence: 99%

Clinical features of acute renal failure associated with hepatitis A virus infection

Jung

Kim

Jeong

et al. 2009

Journal of Viral Hepatitis

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Acute hepatitis A (AHA) is one of the most common infectious diseases; it is usually a self-limiting disease affecting the liver. Although extrahepatic manifestations are not common, some cases have been reported associated with acute renal failure. We reviewed the clinical features of patients with AHA complicated by acute renal failure (ARF group) and compared them with patients with noncomplicated AHA (non-ARF group). The medical records of 208 consecutive patients with AHA who were diagnosed between January 2003 and October 2008 were reviewed. We identified 15 patients (7.2%) with ARF associated with AHA. There were no differences between the ARF and non-ARF group with regard to gender and age. The peak value of alanine aminotransferase (ALT) (median: 6060 IU/L vs 1792 IU/L, P < 0.001), prothrombin time (PT) (International normalized ratio, median 1.72 vs 1.10, P < 0.001), and total bilirubin level (median: 9.6 mg/dL vs 6.3 mg/dL, P = 0.04) were significantly higher in the ARF than in the non-ARF group. Twelve patients (80%) recovered completely with haemodialysis (seven patients, 46.7%) or only conservative management (five patients, 33.3%), while one patient underwent liver transplantation because of fulminant hepatic failure, and two patients died because of fulminant hepatic failure. There were no deaths among patients with noncomplicated AHA in the non-ARF group. Five patients underwent kidney biopsy; two patients were diagnosed with acute tubular necrosis, two patients with acute interstitial nephritis with IgA nephropathy and one patient with acute tubulointerstitial nephritis. All patients in the ARF group had microscopic haematuria and proteinuria (100%vs 31.1%, P < 0.001). Urine sodium levels were more than 10 mEq/L in 10 patients. The findings of high urinary sodium concentrations, microscopic haematuria and proteinuria did not support the diagnosis of hepatorenal syndrome (HRS). Patients with AHA with ARF had higher ALT levels, more prolonged PTs, and higher total bilirubin levels. The prognosis for these patients was poorer than for those without ARF. However, the patients with ARF and nonfulminant AHA had recovered with proper treatment and should not be confused with patients that have HRS.

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Acute Anuric Renal Failure in Nonfulminant Hepatitis A Infection

Cited by 15 publications

References 12 publications

Clinical features and outcomes of acute kidney injury among patients with acute hepatitis A

Clinical features and outcomes of acute kidney injury among patients with acute hepatitis A

Cholestatic hepatitis A complicated by acute renal insufficiency

Clinical features of acute renal failure associated with hepatitis A virus infection

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