Acute anterior uveitis in a patient with sacroiliitis and acne conglobata

Villaverde, Virginia; Hidalgo, Ventura; Cortés, Iván Enrique Porto; Fonseca, Adriana Rodrigues; Gijón-Baños, J; Martı́n-Mola, Emilio

doi:10.1093/rheumatology/38.8.797

Cited by 7 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Association of SAPHO syndrome and uveitis was first reported by Villaverde et al [ 20 ] in a 40-year-old male patient with sacroiliitis, acne conglobata, and acute anterior uveitis. The author suggested that the SAPHO syndrome was part of the spondyloarthropathy spectrum, and uveitis might also be a common extra-articular manifestation of SAPHO syndrome.…”

Section: Discussionmentioning

confidence: 87%

A Case of SAPHO Syndrome Complicated by Uveitis with Good Response to Both TNF Inhibitor and JAKinib

Baisya

Gavali

Tyagi

et al. 2023

Case Reports in Rheumatology

View full text Add to dashboard Cite

Introduction. SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome is a rare autoinflammatory condition describing the constellation of inflammatory skin, bone, and joint manifestations which result in diagnostic difficulty and therapeutic challenge. Case. Here, we present a case of a young male diagnosed with SAPHO syndrome with osteoarticular and cutaneous involvement from an early age in his life. He suffered diagnostic challenges for a long time and was hence inadequately treated. He had minimal response to conventional DMARDs but showed excellent response to TNF inhibitor (adalimumab). Later, he defaulted treatment and presented with acute anterior uveitis which was also dramatically improved with adalimumab and tofacitinib although financial constraint was always an issue for the patient. Conclusion. The uniqueness of this case was that the patient had a multiorgan involvement including osteoarticular system, skin, and eye. Both TNFi (adalimumab) and JAKinib (tofacitinib) had a good response to all organs with a net improvement in the quality of life of this patient.

show abstract

Section: Discussionmentioning

confidence: 87%

A Case of SAPHO Syndrome Complicated by Uveitis with Good Response to Both TNF Inhibitor and JAKinib

Baisya

Gavali

Tyagi

et al. 2023

Case Reports in Rheumatology

View full text Add to dashboard Cite

show abstract

“…PRP type VI related to HIV has been associated with AC [100,101,102,103] often with follicular spicules or spines and explosive AC. PRP has been related to HS in two cases.…”

Section: Pitriasis Rubra Pilaris (Prp) and Acmentioning

confidence: 99%

Diseases associated with hidranitis suppurativa: part 2 of a series on hidradenitis

Scheinfeld¹

2013

Dermatology Online Journal

View full text Add to dashboard Cite

Hidradenitis suppurativa (HS), a pathologic follicular disease, impacts patients' lives profoundly and usually occurs in isolation. The diseases with the strongest association are obesity, depression, and pain. HS is associated with many diseases including acne conglobata (AC), dissecting cellulitis, pilonidal cysts, and obesity. Pyoderma fistulans sinifica (fox den disease) appears to be the same entity as Hurley Stage 2 of 3 HS. The rate of acne vulgaris in HS patients mirrors unaffected controls. The most common, albeit still uncommon, association is with seronegative, haplotype unlinked arthritis (most importantly B27), in particular spondolyarthritis. Crohn disease and HS occur together at a rate that varies from 0.6% to 38% in retrospective cases series. Ulcerative colitis occurred with HS in 14% of patients in one series. The next most common association is with pyoderma gangrenosum, but this association is likely under-reported. Synovitis-Acne-Pustulosis Hyperostosis-Osteitis (SAPHO) syndrome, which is rare, has more than 10 reports linking it to HS. Nine case reports have linked Dowling-Degos disease (DDD) to HS and two reports related HS to Fox-Fordyce disease (FF), but because both occur in the axilla this might be a mere coincidence. HS is rarely associated with ophthalmic pathology. Specifically, more than 5 reports link it to Keratitis-Ichthyosis-Deafness syndrome (KID); greater than10 cases link it to interstitial keratitis and 2 cases are linked to Behçet's disease. The presence of proteinuria and acute nephritis link HS to the kidney, especially since and reports have documented resolution of HS after renal transplant. Florid steatocystoma multiplex, Sjogren Syndrome, and HS have been linked and their reports likely underestimate their coincidence because all these entities involve occlusion (albeit by different mechanisms). Three reports link HS and amyloid, but both share some common genetic underpinnings and thus the coincidence of these diseases is likely underreported. Pyoderma vegetans has been noted in 2 cases of HS and 4 cases of Inflammatory Bowel Disease (IBD) and is likely a clue to the linkage of the pathology of IBD and HS. Pityriasis rubra pilaris, in particular Type VI related to HIV, has a relationship more commonly with acne conglobata, but with HS also. Single case reports of diseases associated with HS include systemic lupus erythematosus, acromegaly, Down syndrome, Bazex-Dupre´-Christol, and prurtis ani, but these might be coincidences. Pyogenic Arthritis, Pyoderma gangrenosum, and Acne (PAPA Syndrome) and Pyoderma gangrenosum, Acne, and Suppurative Hidradenitis (PASH Syndrome) are pyodermic-arthritic syndromes that are associated with HS. Erythema nodosum and granulomatous lobular mastitis have been reported with HS but the significance of these reports is uncertain. Because of scarring, HS can result in lymphedema including scrotal elephantiasis and verrucous lymphedema. HS is sometimes accompanied by obesity, hypertension, and anemia and can be considered a disease in the s...

show abstract

“…Although prior surgery can result in scleritis, the delay of 8 years and presence of systemic inflammation in our case led our Ophthalmologists to consider acne a more likely cause. Anterior uveitis in a patient with AC has been described, but no previous cases have been reported with scleritis . Management of NS should be aggressive to prevent ocular complications, focusing on the underlying condition and the damage caused by ocular inflammation.…”

mentioning

confidence: 95%