Acute Anoxic Cardiac Failure in Pulmonary Heart-Disease

Kellaway, Gavin

doi:10.1016/s0140-6736(59)90862-1

Cited by 17 publications

(4 citation statements)

References 24 publications

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“…In conclusion, this study support the early hypothesis by Kellaway [13] that the arterial 0 2 tension is a major deter minant of the impairment of renal Na+ excretion in pa tients affected by COPD. Oxygen therapy could improve the renal metabolism of Na+ in hypoxemic patients with normal blood C 0 2 levels and ameliorate the efficacy of di uretic therapy.…”

Section: Discussionsupporting

confidence: 90%

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Renal Sodium Excretory Function during Acute Oxygen Administration

Siati

Baldoncini²,

Coassin³

et al. 1993

Respiration

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To evaluate the effect of O₂ administration and O₂ removal on renal Na⁺ excretion, 12 hypoxemic eucapnic patients affected by chronic obstructive pulmonary disease (COPD) and 9 normal subjects were studied. After 1 h in the supine position, O₂ was administered for 3 h by a tight-fitting face-mask. Urine and blood samples for renal Na⁺ excretion evaluation were taken at times 0,60 and 180 min. After O₂ removal both the blood and the urine samples were taken again for a further 3 h. In normal subjects, urinary Na⁺ excretion did not vary after both O₂ administration and removal. On the contrary, in patients affected by COPD renal Na⁺ excretion significantly increased during O₂ administration (from basal values of 0.08 ± 0.01 to 0.17 ± 0.02 mEq/min at 180 min, p < 0.05), and returned to baseline levels (0.13 ± 0.03 mEq/min) after 3 h from O₂ removal. The basal fractional excretion of filtered Na⁺ was significant lower in hypoxemic patients than in normal subjects (0.72 ± 0.3% in patients with COPD vs. 0.95 ± 0.7% in normal subjects, p < 0.05), while, at the end of O₂ administration, it became higher in patients with COPD than in controls (1.62 ± 0.4% in patients with COPD vs. 0.89 ± 0.5 in control subjects, p < 0.001). In conclusion, our findings showed an oxygen-related increase of both the urinary Na⁺ excretion and the fractional excretion of filtered sodium in patients affected by COPD.

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Section: Discussionsupporting

confidence: 90%

“…Kellaway [13] suggested that hypoxia may be the major determinant of Na+ and water retention in pa tients with chronic respiratory failure [13]. Our data seem to support this hypothesis.…”

Section: Discussionsupporting

confidence: 80%

Renal Sodium Excretory Function during Acute Oxygen Administration

Siati

Baldoncini²,

Coassin³

et al. 1993

Respiration

View full text Add to dashboard Cite

show abstract

“…They have carbon dioxide retention in the blood and have become tolerant to higher than normal levels of carbon dioxide. If, however, the anoxia is relieved by the administration of continuous oxygen the stimulus to breathing may be reduced, hypoventilation increased and the patient move into a carbon dioxide narcosis (Platts and Whitaker 1954, Kellaway 1959, Motley et al 1947, Rossier et al 1960).…”

mentioning

confidence: 99%

“…Amiphenazole (Daptazole) has been used with better effect, 30mg. being given intramuscularly every hour or even as often as every 15 minutes when the need was great (Thomas 1959, Kellaway 1959). We have used such therapy for 48 hours with quite good results.…”

mentioning

confidence: 99%