Acute angle plication of optic nerve glioma as a mechanism of rapidly progressive visual loss

Tooley, Andrea A.; Rasool, Nailyn; Campbell, Ashley A.; Kazim, Michael

doi:10.1080/01676830.2020.1733027

Cited by 1 publication

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Optic glioma, which usually occurs in childhood, also leads to optic neuropathy and vision loss [ 200 , 201 ]. A recent study indicated that light plays an important role in glioma formation during eye development [ 202 ].…”

Section: Current Therapy For Retinal Degenerationmentioning

confidence: 99%

The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases

et al. 2022

View full text Add to dashboard Cite

Oxidative stress is mainly caused by intracellular reactive oxygen species (ROS) production, which is highly associated with normal physiological homeostasis and the pathogenesis of diseases, particularly ocular diseases. Autophagy is a self-clearance pathway that removes oxidized cellular components and regulates cellular ROS levels. ROS can modulate autophagy activity through transcriptional and posttranslational mechanisms. Autophagy further triggers transcription factor activation and degrades impaired organelles and proteins to eliminate excessive ROS in cells. Thus, autophagy may play an antioxidant role in protecting ocular cells from oxidative stress. Nevertheless, excessive autophagy may cause autophagic cell death. In this review, we summarize the mechanisms of interaction between ROS and autophagy and their roles in the pathogenesis of several ocular diseases, including glaucoma, age-related macular degeneration (AMD), diabetic retinopathy (DR), and optic nerve atrophy, which are major causes of blindness. The autophagy modulators used to treat ocular diseases are further discussed. The findings of the studies reviewed here might shed light on the development and use of autophagy modulators for the future treatment of ocular diseases.

show abstract

Section: Current Therapy For Retinal Degenerationmentioning

confidence: 99%