Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage

Wilson, Jacob M.; Kim, Jeong‐Su; Lee, Sang Rok; Rathmacher, John A.; Dalmau, Brett; Kingsley, J. Derek; Koch, Heather; Manninen, Anssi H; Saadat, Raz L; Panton, Lynn B.

doi:10.1186/1743-7075-6-6

Cited by 52 publications

(73 citation statements)

References 25 publications

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“…The 100-mm horizontal line of the VAS did not have any marks or numbers, having just indications of ''no soreness'' at beginning and ''extreme soreness'' at end of the line. The soreness quantification was determined by the distance between the initial point line (0 mm) and the point marked by the subject (French et al 2008;White et al 2008;Wilson et al 2009). …”

Section: Muscle Soreness-vasmentioning

confidence: 99%

Low level laser therapy before eccentric exercise reduces muscle damage markers in humans

et al. 2010

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The purpose of the present study was to determine the effect of low level laser therapy (LLLT) treatment before knee extensor eccentric exercise on indirect markers of muscle damage. Thirty-six healthy men were randomized in LLLT group (n = 18) and placebo group (n = 18). After LLLT or placebo treatment, subjects performed 75 maximal knee extensors eccentric contractions (five sets of 15 repetitions; velocity = 60° seg(-1); range of motion = 60°). Muscle soreness (visual analogue scale--VAS), lactate dehydrogenase (LDH) and creatine kinase (CK) levels were measured prior to exercise, and 24 and 48 h after exercise. Muscle function (maximal voluntary contraction--MVC) was measured before exercise, immediately after, and 24 and 48 h post-exercise. Groups had no difference on kineanthropometric characteristics and on eccentric exercise performance. They also presented similar baseline values of VAS (0.00 mm for LLLT and placebo groups), LDH (LLLT = 186 IU/l; placebo = 183 IU/l), CK (LLLT = 145 IU/l; placebo = 155 IU/l) and MVC (LLLT = 293 Nm; placebo = 284 Nm). VAS data did not show group by time interaction (P = 0.066). In the other outcomes, LLLT group presented (1) smaller increase on LDH values 48 h post-exercise (LLLT = 366 IU/l; placebo = 484 IU/l; P = 0.017); (2) smaller increase on CK values 24 h (LLLT = 272 IU/l; placebo = 498 IU/l; P = 0.020) and 48 h (LLLT = 436 IU/l; placebo = 1328 IU/l; P < 0.001) post-exercise; (3) smaller decrease on MVC immediately after exercise (LLLT = 189 Nm; placebo = 154 Nm; P = 0.011), and 24 h (LLLT = 249 Nm; placebo = 205 Nm; P = 0.004) and 48 h (LLLT = 267 Nm; placebo = 216 Nm; P = 0.001) post-exercise compared with the placebo group. In conclusion, LLLT treatment before eccentric exercise was effective in terms of attenuating the increase of muscle proteins in the blood serum and the decrease in muscle force.

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Section: Muscle Soreness-vasmentioning

confidence: 99%

Low level laser therapy before eccentric exercise reduces muscle damage markers in humans

et al. 2010

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“…Parece que la dosis de HMB adecuada es de 3 g/día, distribuida en 3 tomas (27,28,30,34): una dosis antes del entrenamiento y las otras dos en dos de las comidas principales. Esta recomendación se basa en el menor aumento de los niveles de CK y LDH si se ingiere antes del entrenamiento (34).…”

Section: Dosisunclassified

“…Esta recomendación se basa en el menor aumento de los niveles de CK y LDH si se ingiere antes del entrenamiento (34). Debido a que el tiempo que tarda en alcanzarse el pico de HMB en sangre es diferente con la sal de calcio (HMB-Ca) que con la forma libre (HMB-FA), se recomienda que la dosis previa al entrenamiento sea 1 hora antes en el caso del HMB-Ca y 30 minutos antes en el caso del HMB-FA (22).…”

Section: Dosisunclassified

Ayudas ergogénicas en el deporte

Moriones¹,

Santos²

2017

Nutr Hosp

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Introduction: Very few nutritional supplements have scientifi cally demonstrated their effectiveness as an ergogenic aid. This review will examine creatine monohydrate (MC), the β-hydroxy-β-methylbutyrate (HMB), sodium bicarbonate (BS), the β-alanine and caffeine. Objectives: To analyze the effi cacy, mechanisms of action, dose, side effects and some sports that can benefi t from their consumption. Methods: Searching in PubMed bibliographic database reviews from the last 15 years and original articles from the last 5 years of the studied substances. Results: Doses of 20 mg/day for 4-7 days are effective in improving strength and muscular power and performance in short and repeated sprints. HMB at doses of 3 g/day for at least 2 weeks contributes to increased lean mass and fat-free mass. The intake of 0.3 g/kg of BS improves performance on tests of 400-1,500 meters in athletics and intermittent sprints. Meanwhile, doses of 80 mg/kg/day of β-alanine for 4-10 weeks may improve performance in high-intensity intermittent exercise. Finally, caffeine at doses of 2 mg/kg improves responsiveness and 3-6 mg/kg improves performance in endurance tests. Conclusions: The revised supplements have shown their effi cacy in physical performance, but it is needed to keep in mind that most studies have been conducted with recreational-level athletes. Generally, the better the individual´s fi tness level is the less improvement in physical performance the supplement shows. However, an increase of only 1% may sometimes allow the athlete to advance several positions in a fi nal. Finally, we should draw attention to the importance of optimizing nutrition before considering the introduction of sports supplements, especially in children and youth. All analyzed substances have scientifi c basis supporting its ergogenic effect. All of them can be found in the market with Certifi cate of Quality and Purity.

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“…Dos marcadores indiretos de DMIE, a avaliação da função muscular a partir do desempenho de força tem sido uma das mais utilizadas na literatura (PADDON-JONES, KEECH, JENKINS, 2001; VAN SOMEREN, EDWARDS, HOWATSON, 2005;HOWATSON et al, 2012;KIRBY et al, 2012 WILSON et al, 2009;KIRBY et al, 2012;HOWATSON et al, 2012;WALDRON et al, 2017).…”

Section: Marcadores Utilizados Na Avaliação Do Dmieunclassified

“…O consumo desse subproduto do aminoácido LEU é associado à redução do catabolismo muscular, ao aumento de força, à maior hipertrofia muscular e atenuação do DMIE (NISSEN et al,1996;PANTON et al, 2000;JOWKO et al, 2001;KNITTER et al, 2000;VAN SOMEREN, EDWARDS, HOWATSON, 2005;WILSON et al, 2014). A dose diária de HMβ utilizada na maioria dos estudos é de 3g (NISSEN et al, 1996;PANTON et al, 2000;KNITTER et al, 2000; VAN SOMEREN, EDWARDS, HOWATSON, 2005;WILSON et al, 2009;WILSON et al, 2013;WILSON et al, 2014). Essa dose é decorrente de estudos preliminares que apontaram sua superioridade quanto a doses menores, 1,5g (NISSEN et al, 1996) e ausência de efeitos adicionais com dose mais elevada, 6g (GALLANGHER et al, 2000).…”

Section: β-Hidroxi-β-metilburitato (Hmβ)unclassified

Estratégias nutricionais para minimizar o dano muscular induzido pelo exercício de força

Barbosa¹

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Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage

Cited by 52 publications

References 25 publications

Low level laser therapy before eccentric exercise reduces muscle damage markers in humans

Low level laser therapy before eccentric exercise reduces muscle damage markers in humans

Ayudas ergogénicas en el deporte

Estratégias nutricionais para minimizar o dano muscular induzido pelo exercício de força

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