Acute and Subchronic Toxicity Profile of Euphorbia pulcherrima Methanol Extract on Wistar Albino Rats

Abstract

This work was designed to evaluate the acute and subchronic toxicity ofE. pulcherrimamethanol extract. Mean lethal dose (LD50) and subchronic toxicity were determined using Lorke’s method to assess the effect of the extract on kidney and liver functions along histopathology assessment of the liver and kidney, respectively. The LD50determined was 3807.89 mg/kg both orally and intraperitoneally. The kidney function parameters indicated elevation of the serum urea above the normal value in both control and the group treated with 10 mg/kg of the extract with mean values of 7.92 ± 1.19 and 7.86 ± 1.14 mMol/L, respectively. The creatinine and electrolytes were within the normal values. The results of ALAT, ASAT, ALP, T protein albumin, and bilirubin in all cases were within the normal values. Kidney, liver function parameters, and relative organ weight were statistically insignificant across all groups. This shows that various concentrations ofE. pulcherrimaextract did not influence negatively the liver and kidney function parameters. Further studies are required to rule out the observed mild hepatic histological changes among a few members of the groups treated with 100 and 1000 mg/kg/day and any possible hepatoprotective and nephron-protective potential the extract may possess.

In vivo and in silico investigations of the toxicological and analgesic properties of unprocessed Aloe vera gel in experimental rat models

“…Hemoglobin was measured immediately after blood collection. All the experiments were performed according to the standard guidelines with slight modifications [13,14].…”

Antiviral Activity of Euphorbia Lectin Against Herpes Simplex Virus 1 and its Antiproliferative Activity Against Human Cancer Cell-Line

“…Whole plant or stem were collected and thoroughly washed with 2% sodium hypochlorite solution and subsequently with sterial distilled water. After sterilization, the stems were dried and grounded to powder [21].…”

Toxicological, Bioassay-Guided Fractionation and Antibacterial Activity of Methanol Stem Extract of Terminalia microptera on Oral Bacteria Pathogens

“…This is on the grounds that the traditional herbal practitioners find it difficult to determine the actual or effective safe dose and delayed or adverse effects resulting from prolong use of these extracts. 35 This study was therefore aimed at evaluating the toxicological, bioassay-guided fractionation and antibacterial activity of methanol stem extract of Terminalia microptera on oral bacterial pathogens.…”