Acute and subchronic toxicity profile of methanol extract of leaves of Fimbristylis miliacea (L.) Vahl

Roy, Roni; Liya, Israt Jahan; Roy, Jony; Basher, Mohammad Anwarul

doi:10.1016/j.toxrep.2023.02.006

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…Consequently, this study showed that supplementation with leaf protein concentrate of E. speciosa in both the challenged and unchallenged groups resulted in significantly higher erythron values compared to the negative control.This observation agrees with the findings of Ndem et al (2013) who indicated that E. speciosa leaf extract showed a similar antianaemic activity at 300 mg/kg and mg/kg respectively. According to Roy et al (2023) Aspartate aminotransferase and Alanine aminotransferase show rapidly increased levels when the liver is damaged for reasons such as hepatic cell necrosis, hepatitis, cirrhosis and intoxication with xenobiotics. Alanine amino transferase is a hepatic cytosolic enzyme, quite specific of liver injury, and released into the blood stream when there is liver cell necrosis, while AST is also found in some other organs such as the lungs, heart, skeletal muscle, and kidneys.…”

Section: Discussionmentioning

confidence: 99%

Anti-anaemic effects of leaf protein concentrate of Eremomastax speciosa (Hochst) Cufod. on some blood parameters of male Sprague-Dawley rats exposed to phenylhydrazine-induced anaemia

Nwaigwe,

Obiekwe

et al. 2023

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This study investigated the effects of leaf protein concentrate (LPC) of Eremomastax speciosa (Hochst.) Cufod on some haematological and serum profile of 45 male Sprague-Dawley rats divided into nine groups of five rats per group. The rats received fresh drinking water daily, with feed at 85% of ad-lib. The standard haematinic used was Ranferon-12®, at the dose of 0.3ml/kg body weight. The resultant groups were; Group1 (Positive control, received commercial feed) Group 2 (phenylhydrazine only or negative control), Group 3 (anaemia +haematinic), 4, 5 and 6 (anaemia +100 mg/kg, 200 mg/kg and 400 mg/kg of LPC respectively), Groups 7, 8, 9 (Untreated (or UT) +100 mg/kg, 200 mg/kg and 400 mg/kg of LPC respectively). The LPC was administered orally to the designated groups, while the controls received distilled water in place of the LPC. Anaemia was induced by intraperitoneal injection of phenylhydrazine at 40 mg/kg for 2 days. Samples for haematological and biochemical analysis were collected on days 9, 21 and 28 of the experiment. Results showed that the groups supplemented with LPC were better in terms of the haematology and serum biochemical values compared to the negative control, and this strongly supported the traditional use of E. speciosa leaf in the treatment of anaemia.

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Section: Discussionmentioning

confidence: 99%

Anti-anaemic effects of leaf protein concentrate of Eremomastax speciosa (Hochst) Cufod. on some blood parameters of male Sprague-Dawley rats exposed to phenylhydrazine-induced anaemia

Nwaigwe,

Obiekwe

et al. 2023

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28-day repeated-dose toxicity of orally administered Jinmao Jiedu granule in Sprague-Dawley rats

Ren,

Peng,

et al. 2024

Journal of Chromatography B

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Acute and subchronic toxicity profile of methanol extract of leaves of Fimbristylis miliacea (L.) Vahl

Cited by 2 publications

References 25 publications

Anti-anaemic effects of leaf protein concentrate of Eremomastax speciosa (Hochst) Cufod. on some blood parameters of male Sprague-Dawley rats exposed to phenylhydrazine-induced anaemia

Anti-anaemic effects of leaf protein concentrate of Eremomastax speciosa (Hochst) Cufod. on some blood parameters of male Sprague-Dawley rats exposed to phenylhydrazine-induced anaemia

28-day repeated-dose toxicity of orally administered Jinmao Jiedu granule in Sprague-Dawley rats

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