Acute and subchronic oral toxicity of fluoranthene in F-344 rats

Knuckles, Maurice E.; Inyang, Frank; Ramesh, Aramandla

doi:10.1016/s0147-6513(03)00110-6

Cited by 24 publications

(16 citation statements)

References 25 publications

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“…As in the case of HDBB, the male-predominant induction of toxicity in rats has been reported for many other substances, such as adenine (Ogirima et al, 2006), acetaminophen (Raheja et al, 1983), dapsone (Coleman et al, 1990), fluoranthene (Knuckles et al, 2004), 3-nitropropionic acid (Nishino et al, 1998), and mercuric chloride (Muraoka and Itoh, 1980). Various causes of such genderrelated differences are indicated mainly for toxicokinetic determinants.…”

Section: Malementioning

confidence: 95%

“…Gender-related differences in susceptibility to toxicity have been documented for other substances; for example, a subchronic toxicity study in rats showed that fluoranthene, a polycyclic aromatic hydrocarbon, had greater effects on males than females, especially on the kidneys (Knuckles et al, 2004). In contrast, female rats exhibited greater susceptibility to hypothalamic cholinesterase inhibitory and hypothermic effects of a carbamate cholinesterase inhibitor, rivastigmine (Wang et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Gonadal Influence on the Toxicity of 2-(2′-Hydroxy-3′,5′-di-tert-butylphenyl) benzotriazole in Rats

Hirata-Koizumi

Matsuyama

Imai

et al. 2008

Drug and Chemical Toxicology

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Previously, we showed that susceptibility of male rats to the toxicity of an ultraviolet absorber, 2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole (HDBB), was nearly 25 times higher than that of females. In the current study, we investigated the role of sex steroids in the mediation of the gender-related difference using castrated rats. Male and female castrated CD(SD) rats were given HDBB by gavage at 0, 0.5, 2.5, or 12.5 mg/kg/day for 28 days. No deaths, clinical signs of toxicity, or changes in body weight or food consumption were found at any doses. Blood biochemical changes suggestive of hepatic damage, such as increased levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase, were detected at 12.5 mg/kg/day in males. Absolute and relative liver weight increased at 0.5 mg/kg/day and above in males and at 12.5 mg/kg/day in females. In the liver, histopathological changes, such as nucleolar enlargement, increased mitosis, hypertrophy in hepatocytes, and/or focal necrosis were observed at 0.5 mg/kg/day and above in males, and at 2.5 mg/kg/day and above in females. These findings indicate that castration markedly reduced the gender-related differences in toxicity of HDBB in rats.

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Section: Malementioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Gonadal Influence on the Toxicity of 2-(2′-Hydroxy-3′,5′-di-tert-butylphenyl) benzotriazole in Rats

Hirata-Koizumi

Matsuyama

Imai

et al. 2008

Drug and Chemical Toxicology

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“…The oral cancer risk (1:10 4 excess lifetime cancer risk for oral exposure) for FLA was calculated as 50 Ag/kg body weight [5]. FLA was also reported to cause lung and liver tumors [6], apoptosis in T cells [7], decrease in white blood counts and tubular casts in kidneys [8]. When inhaled or ingested, FLA becomes activated in biological systems and, as a consequence, the reactive metabolites formed cause toxicity [9].…”

Section: Introductionmentioning

confidence: 99%

Effect of dietary fat on metabolism and DNA adduct formation after acute oral exposure of F-344 rats to fluoranthene☆

Walker

Addai

Mathis

et al. 2007

The Journal of Nutritional Biochemistry

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“…For example, a recent subchronic toxicity study using F344 rats showed that fluoranthene, a polycyclic aromatic hydrocarbon, had greater effects on males than females (especially on the kidneys) (Knuckles et al, 2004). In contrast, it was reported that female rats exhibited a greater Downloaded by [RMIT University] at 16:56 10 August 2015…”

Section: Malementioning

confidence: 99%

A 28-Day Repeated Dose Toxicity Study of Ultraviolet Absorber 2-(2′-Hydroxy-3′,5′-di-tert-butylphenyl) benzotriazole in Rats

Hirata-Koizumi

Watari²,

Mukai³

et al. 2007

Drug and Chemical Toxicology

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To examine the possible repeated-dose toxicity of an ultraviolet absorber, 2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole (HDBB), CD(SD)IGS rats were administered HDBB by gavage at a dose of 0 (vehicle: corn oil), 0.5, 2.5, 12.5, or 62.5 mg kg(-1) day(-1) for 28 days. At the completion of the administration period, a decrease in red blood cells, hemoglobin, and hematocrit was noted only in males at 2.5 mg/kg and more. Blood biochemical changes were noted at 0.5 mg/kg and more in males and at 62.5 mg/kg in females. Histopathologic changes were observed principally in the liver (vacuolar degeneration and hypertrophy of hepatocytes, bile duct proliferation, etc.) and in the heart (degeneration and hypertrophy of myocardium and cell infiltration). These changes were noted at 0.5 mg/kg and more in males and at 12.5 mg/kg and more in females. At higher doses, hypertrophy of tubular epithelium in the kidneys and diffuse follicular cell hyperplasia in the thyroids in both sexes and increased severity of basophilic tubules in the kidneys and extramedullary hematopoiesis in the spleen in males were also detected. After the 14-day recovery period, these changes mostly recovered in females but not in males. Based on these findings, no observed adverse effect level (NOAEL) was concluded to be less than 0.5 mg kg(-1) day(-1) in male rats and 2.5 mg kg(-1) day(-1) in female rats.

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Acute and subchronic oral toxicity of fluoranthene in F-344 rats

Cited by 24 publications

References 25 publications

Gonadal Influence on the Toxicity of 2-(2′-Hydroxy-3′,5′-di-tert-butylphenyl) benzotriazole in Rats

Gonadal Influence on the Toxicity of 2-(2′-Hydroxy-3′,5′-di-tert-butylphenyl) benzotriazole in Rats

Effect of dietary fat on metabolism and DNA adduct formation after acute oral exposure of F-344 rats to fluoranthene☆

A 28-Day Repeated Dose Toxicity Study of Ultraviolet Absorber 2-(2′-Hydroxy-3′,5′-di-tert-butylphenyl) benzotriazole in Rats

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