Acute and subacute toxicity of Cassia occidentalis L. stem and leaf in Wistar rats

Abstract

Our results showed that acute or subacute administration of Cassia occidentalis is not toxic in male and female Wistar rats, suggesting a safety use by humans.

Sub-acute Toxicity of Aqueous Extracts of Tephrosia vogelii, Vernonia amygdalina and Senna occidentalis in Rats

“…These results support previous findings that the SO leaf extract is hepatoprotective [39]. On the contrary, in a previous study, there was no change in liver enzymes and haematological parameters in female and male rats for SO at doses as high as 2500 mg/kg/day [28]. Their study therefore, did not report any toxicity of SO in the male or female rats.…”

“…It has good antimicrobial, anti-mutagenic, anti-inflammatory, anti-diabetic and anti-malarial activity [18][19][20]. Acute toxicity studies of leaves of TV [21], VA [15,22,23] and seeds of SO [24][25][26][27][28] have been studied in different animals. The objective of this study was to determine the sub-acute toxicity due to prolonged administration of these three commonly used plants in rats.…”

Acute and Sub-acute Toxicity of <i>Crataegus Aronia Syn. Azarolus</i> (L.) Whole Plant Aqueous Extract in Wistar Rats

“…Hence, the administration of the extracts in increasing amounts enables the evaluation of the acute and sub-acute toxicity limits. Therefore, the test should be carried out for three doses and for both sexes, taking into account other factors such as age, weight, species, diet and environmental conditions (Silva et al, 2011).…”

In vitro and in vivo antifungal activity, liver profile test, and mutagenic activity of five plants used in traditional Mexican medicine

“…These observations, as well as the serum levels of bilirubin and transaminases, established the absence of hepatocellular damage induced by the extracts. Histological analysis and biochemical parameters are essential for evaluating the toxicological risk of substances with biological activity because any changes in one of these parameters in animal studies can provide a high predictive value of potential damage in humans (Carvalho et al, 2011;Olson et al, 2000;Silva et al, 2011).…”