Acute and subacute toxicity of Schinus terebinthifolius bark extract

Lima, Liliane Bezerra de; Vasconcelos, Carlos Fernando Brasileiro de; Maranhão, H.M.L.; Leite, Valéria Moura Moreira; Ferreira, Pablo A.; Andrade, Bruno Augusto Benevenuto De; Araújo, Erica Lôpo de; Xavier, Haroudo Sátiro; Lafayette, Simone S.L.; Wanderley, Almir Gonçalves

doi:10.1016/j.jep.2009.09.013

Cited by 31 publications

(37 citation statements)

References 22 publications

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“…Although a slight decrease was observed, the results reported here indicated that concentration levels of these both enzymes in treated animals did not show a significant difference compared to the negative control (p > 0.05). This finding showed that the aqueous leaf extract at these tested oral doses may not cause liver, heart or kidney damages as also previously reported by [29] [30]. Moreover, the hepatic function of these animals can be considered to be maintained [31].…”

Section: Effects Of the Aqueous Extract Of B Sumatrana Leaves On Thesupporting

confidence: 86%

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Study of Antiparasitic and Cytotoxicity of the Aqueous, the 80% Methanol Extract and Its Fractions, and the Acute Toxicity of the Aqueous Extract of <i>Brucea sumatrana</i> (Simaroubaceae) Leaves Collected in Mai-Ndombe, Democratic Republic of Congo

Ehata¹,

Lumpu²,

Munduku³

et al. 2016

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Results from the in vitro evaluation of the antiparasitaire activity of the aqueous extract, the 80% methanol extract and its fractions from the leaves of Brucea sumatrana against Trypanosoma brucei brucei, T. cruzi, Leishmania infantum, the multidrugresistant K1 and chloroquine-sensitive NF54 strains of Plasmodium falciparum indicated that all samples from the leaves extract presented interesting antiparasitaire activity at different extents. The 80% methanol extract, its chloroform acid, petroleum ether and 80% methanol soluble fractions and the aqueous extract exhibited strong activity against Trypanosoma b. brucei, T. cruzi, L. infantum and the multidrug-resistant K1 strain of P. falciparum with IC 50 values from <0.25 to 4.35 µg/ml as well as against chloroquine-sensitive NF54 strain of P. falciparum with IC 50 values ranging from <0.02 to 2.0.4 µg/ml. Most samples were cytotoxic against MRC-5 cell lines (0.2 < cytotoxic concentration 50(CC 50 ) < 34.24 µg/ml) and showed good selective effect against all tested parasites. In acute toxicity, the aqueous extract was found to be non-toxic and its LD 50 was estimated to be greater than 5 g/kg. In addition, it did not significantly modify the concentration levels of some evaluated biochemical How to cite this paper: Ehata, M.T., Lumpu, S.N., Munduku, C.K., Kabangu, O.K., Cos, P., Maes, L., Apers, S., Vlietinck, A.J., Pieters, L. and Kanyanga, R.C. (2016) 94and hematological parameters in treated rats. These results constitute a scientific validation supporting and justifying the traditional use of the leaves of B. sumatrana for the treatment of malaria, sleeping sickness and at some extent Chagas disease.

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Section: Effects Of the Aqueous Extract Of B Sumatrana Leaves On Thesupporting

confidence: 86%

“…Since it is produced in the liver, its decrease in serum may arise from liver and kidney diseases [29]. Fortunately, a slight decrease of the concentration level of albumin was observed, but did not show significant difference compared to untreated groups (p > 0.05).…”

Section: Effects the Aqueous Extract Of B Sumatrana Leaves On The Comentioning

confidence: 87%

Study of Antiparasitic and Cytotoxicity of the Aqueous, the 80% Methanol Extract and Its Fractions, and the Acute Toxicity of the Aqueous Extract of <i>Brucea sumatrana</i> (Simaroubaceae) Leaves Collected in Mai-Ndombe, Democratic Republic of Congo

Ehata¹,

Lumpu²,

Munduku³

et al. 2016

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“…The hematological and biochemical analysis did not show significant differences in any of the parameters examined in female or male groups, except in two male groups, in which the treatment with S. terebinthifolius (0.25 and 0.625 g/kg) induced an increase of mean corpuscular volume values (2.9 and 2.6 %, respectively). These variations are within the physiological limits described for the specie and does not have clinical relevance (Lima et al, 2009).…”

Section: Toxicologysupporting

confidence: 55%

Brazilian Pepper Tree: Review of Pharmacology

Patočka¹,

Almeida²

2017

Mil. Med. Sci. Lett.

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SummaryBrazilian pepper tree (Schinus terebinthifolius Raddi) from the Anacardiaceae family is native to Central and South America. In folk medicine, S. terebinthifolius has been used as a remedy for ulcers, respiratory problems, wounds, rheumatism, gout, diarrhea, skin ailments and arthritis, as well as to treat tumors and leprosy. The Brazilian pepper tree has various biological properties and it is a source of many bioactive compounds. Several classes of compounds can be found in extracts obtained from these plants, such as terpenes and flavonoids. Essential oils obtained by steam distillation or extraction by solvents from berries or leafs is rich in monoterpenes and shows interesting antioxidant activity. It has displayed good-to-very strong in vitro antifungal actions against numerous fungi, as well as Candida. The essential oil and leaves have demonstrated in vitro antibacterial activity against numerous bacterial strains.

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“…In our work, we observed discrete biochemical and histological changes after the administration of dolabelladienotriol, showing that some injuries might occur and might not be completely reversible. In fact, others have shown that applications of plant extracts or their products can cause changes in the tissues of organs such as the liver, kidney and others (Baliga et al, 2004;Lima et al, 2009;Mariz et al, 2006;Mukinda & Syce, 2007;Omar et al, 1996;Rauber et al, 2006). The rationale for choosing acyclovir (de Miranda et al, 1981) as the control (50 mg/kg) was to compare dolabelladienotriol with a drug already used as an antiviral agent against HSV-1 in the clinical setting.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice

Garrido¹,

Teixeira²,

Teixeira³

et al. 2011

Rev. bras. farmacogn.

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Dolabelladienotriol is a product extracted from the brown marine alga Dictyota pfaffii from Brazil that has been shown to have antiviral activity and low cytotoxicity. Our studies have evaluated the acute toxicity of dolabelladienotriol in BALB/c mice for ten days after administration of a single dose. Among the parameters considered were behavior, weight, biochemical and histological analyses of blood samples taken at three different times (Bs.0, Bs.1 and Bs.2) and optical microscopic examination of organs like liver, kidney, stomach and small intestine. Mice deaths were not observed at any dose during the ten day period. There were some changes in the biochemical analysis results for urea nitrogen (BUN) and alanine aminotransferase (ALT), but the changes were not significantly different from the reference levels of the animals before administration of the substance. Histological analyses of tissues were very similar for all animals. The alterations in liver and kidney tissues did not affect the animals´ behavior at any concentration, not even at 50 mg/kg, where the most significant changes in tissues were seen. This study indicates that dolabelladienotriol has low toxicity in administered dose range.

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Acute and subacute toxicity of Schinus terebinthifolius bark extract

Abstract: The acute and subacute administration of the dried extract of Schinus terebinthifolius bark did not produced toxic effects in Wistar rats.

Cited by 31 publications

References 22 publications

Study of Antiparasitic and Cytotoxicity of the Aqueous, the 80% Methanol Extract and Its Fractions, and the Acute Toxicity of the Aqueous Extract of <i>Brucea sumatrana</i> (Simaroubaceae) Leaves Collected in Mai-Ndombe, Democratic Republic of Congo

Study of Antiparasitic and Cytotoxicity of the Aqueous, the 80% Methanol Extract and Its Fractions, and the Acute Toxicity of the Aqueous Extract of <i>Brucea sumatrana</i> (Simaroubaceae) Leaves Collected in Mai-Ndombe, Democratic Republic of Congo

Brazilian Pepper Tree: Review of Pharmacology

Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice

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Acute and subacute toxicity of Schinus terebinthifolius bark extract

Abstract: The acute and subacute administration of the dried extract of Schinus terebinthifolius bark did not produced toxic effects in Wistar rats.

Cited by 31 publications

References 22 publications

Study of Antiparasitic and Cytotoxicity of the Aqueous, the 80% Methanol Extract and Its Fractions, and the Acute Toxicity of the Aqueous Extract of &lt;i&gt;Brucea sumatrana&lt;/i&gt; (Simaroubaceae) Leaves Collected in Mai-Ndombe, Democratic Republic of Congo

Study of Antiparasitic and Cytotoxicity of the Aqueous, the 80% Methanol Extract and Its Fractions, and the Acute Toxicity of the Aqueous Extract of &lt;i&gt;Brucea sumatrana&lt;/i&gt; (Simaroubaceae) Leaves Collected in Mai-Ndombe, Democratic Republic of Congo

Brazilian Pepper Tree: Review of Pharmacology

Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice

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Study of Antiparasitic and Cytotoxicity of the Aqueous, the 80% Methanol Extract and Its Fractions, and the Acute Toxicity of the Aqueous Extract of <i>Brucea sumatrana</i> (Simaroubaceae) Leaves Collected in Mai-Ndombe, Democratic Republic of Congo

Study of Antiparasitic and Cytotoxicity of the Aqueous, the 80% Methanol Extract and Its Fractions, and the Acute Toxicity of the Aqueous Extract of <i>Brucea sumatrana</i> (Simaroubaceae) Leaves Collected in Mai-Ndombe, Democratic Republic of Congo