Acute and subacute toxicity of Salvia scutellarioides in mice and rats

Ramírez, Jorge H; Palacios, Mauricio; Tamayo, Oscar; Jaramillo, Roberto; Gutiérrez, Óscar

doi:10.1016/j.jep.2006.07.040

Cited by 12 publications

(6 citation statements)

References 8 publications

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“…Hence, the oral LD 50 value of extract may be interpreted to be higher than 2000 mg/kg, indicating that the extract is practically nontoxic in mice, as per the criterion of the OECD guidelines. This finding is in agreement with a related study in which the acute toxicity of Salvia scutellarioides extract was investigated in mice, using the up and down procedure of the OECD guidelines [36]. In the latter study also, treatment with 2000 mg/kg dose of S. scutellarioides extract did neither reveal any change in the general appearance of experimental animals nor does it caused mortality of animals up to the observation period of 14 days [36].…”

Section: Discussionsupporting

confidence: 91%

Anthelmintic effects and toxicity of Cynodon dactylon (L.) Pers. in rodent models

Yadav¹,

Nath²

2017

J Intercult Ethnopharmacol

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Section: Discussionsupporting

confidence: 91%

Anthelmintic effects and toxicity of Cynodon dactylon (L.) Pers. in rodent models

Yadav¹,

Nath²

2017

J Intercult Ethnopharmacol

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“…Aqueous extract of Salvia scutellarioides Kunth was administered on mice in two doses of 1 or 2 g/kg for 28 days (Ramirez et al, 2007). The administration showed no mortality.…”

Section: Toxicological Studiesmentioning

confidence: 99%

“…The study also claimed that if S. scutellarioides is taken together with other diuretics drug, it might worsen hypokalemia symptoms or increase in digoxin related arrhythmias in patients because of the herb-drug interactions. (Ramirez et al, 2007). Teucrium polium L. is known for its risk of hepatotoxicity due to hepatocyte necrosis occurs massively in the central lobular area such as lymphocyte inflammatory inflate, bile duct proliferation, and bile retention.…”

Section: Toxicological Studiesmentioning

confidence: 99%

A Review on the Potential Use of Medicinal Plants From Asteraceae and Lamiaceae Plant Family in Cardiovascular Diseases

2020

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Cardiovascular diseases are one of the most prevalent diseases worldwide, and its rate of mortality is rising annually. In accordance with the current condition, studies on medicinal plants upon their activity on cardiovascular diseases are often being encouraged to be used in cardiovascular disease management, due to the availability of medicinal values in certain dedicated plants. This review was conducted based on two plant families, which are Asteraceae and Lamiaceae, to study on their action in cardiovascular disease relieving activities, to review the relationship between the phytochemistry of Asteraceae and Lamiaceae families and their effect on cardiovascular diseases, and to study their toxicology. The medicinal plants from these plant family groups are collected based on their effects on the mechanisms that affect the cardiovascular-related disease which are an antioxidant activity, anti-hyperlipidemic or hypocholesterolemia, vasorelaxant effect, antithrombotic action, and diuresis effect. In reference to various studies, the journals that conducted in vivo or in vitro experiments, which were used to prove the specific mechanisms, are included in this review. This is to ensure that the scientific value and the phytochemicals of the involved plants can be seen based on their activity. As a result, various plant species from both Asteraceae and Lamiaceae plant family have been identified and collected based on their study that has proven their effectiveness and uses in cardiovascular diseases. Most of the plants have an antioxidant effect, followed by anti-hyperlipidemia, vasorelaxant, antithrombotic, and diuretic effect from the most available to least available studies, respectively. These are the mechanisms that contribute to various cardiovascular diseases, such as heart attack, stroke, coronary heart disease, and hypertension. Further studies can be conducted on these plant species by identifying their ability and capability to be developed into a new drug or to be used as a medicinal plant in treating various cardiovascular diseases.

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“…The sub-acute oral dose toxicity study of CO extract was performed inaccordance with the method described by the former researchers to evaluate the sub-acute toxicity [12,13]. On daily basis manner for 14 days, three different doses (250, 500 and 1000 mg/kg/day) of the CO extract were given orally to three groups of randomly selected male rats (6 each).…”

Section: Oral Toxicity In Rats By Repeated Dose Administrationmentioning

confidence: 99%

Evaluation of the Toxicological Profile of Commiphora opobalsamum in Wister Rats for Its Safety and Rational Use

Ahmad

Al-Salmi

Kamel

et al. 2021

JPRI

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Aim: To study acute and chronic toxicity profile of Commiphora opobalsamum (CO) in rats. Methods: Acute oral lethal effect and single oral dose toxicity of CO was determined in rats by comparison with standard control. In contrast repeated dose oral toxicity in rats were performed in four groups of rats, CO was orally administered to three groups of rats in graded doses (250, 500 and 1000 mg/kg/day) once daily for 14 daysVs standard control. The sub-acute toxicity of CO was observed on hematological, coagulation and biochemical parameters. Results: Acute oral lethal dose of CO in rats was demonstrated to be safe and higher than the tested dose i.e., 2000 mg/kg, moreover, single oral dose toxicity revealed no symptoms of toxicity. Furthermore, sub-acute toxicological effect on hematological analysis of CO rats groups treated withgraded dosed after 14 days treatment revealed insignificant decrease in complete blood count (CBC)in contrast with the control group (p>0.05) additionally the biochemical parameters includedanalysis of urea, creatinine, glucose; lipid profile and thyroid function markers fairly demonstrated insignificant differences utilizing the same methodology. Conclusion: Our current explorative study strongly substantiates that the CO extract have no significantoral toxicity in rats and even the results of 14 days oral treatment indicated that there were no obvious toxic effects at the dosage of 1000 mg/kg/day. The comprehensive sub-acute toxicological effect of CO extracts on hematological and coagulation parameters and biochemical parameters included analysis of urea, creatinine, glucose; lipid profile and thyroid function markers fairly demonstrated no significant harmful outcome even after 14 days treatment with CO.

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Acute and subacute toxicity of Salvia scutellarioides in mice and rats

Cited by 12 publications

References 8 publications

Anthelmintic effects and toxicity of Cynodon dactylon (L.) Pers. in rodent models

Anthelmintic effects and toxicity of Cynodon dactylon (L.) Pers. in rodent models

A Review on the Potential Use of Medicinal Plants From Asteraceae and Lamiaceae Plant Family in Cardiovascular Diseases

Evaluation of the Toxicological Profile of Commiphora opobalsamum in Wister Rats for Its Safety and Rational Use

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