Acute and sub-chronic toxicity study of Brahmi ghrita in rodents

Reddy, K. R. C.; Kumar, Vikas; Yadav, K. D. S.

doi:10.4103/0973-8258.126814

Cited by 4 publications

(1 citation statement)

References 22 publications

(22 reference statements)

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“…[374] Furthermore, various researchers conducted toxicity studies on various Bacopa monnieri formulations, such as Deo et al, compiled acute and subchronic toxicity studies of Brahmi ghrita in rodents and concluded that Brahmi ghrita is safe in rodents and mice at doses of 1, 2.5, and 5 g/kg, p.o. [375] Similarly, no evidence of toxicity was found in a 90-day subchronic oral toxicity study in rats of BacoMind, an enriched phytochemical composition derived from Bacopa monnieri, at doses of 85, 210, and 500 mg/kg, in terms of clinical effects, neurological examination, weight gain, or hematological parameters. There were no signs of degradation after a necropsy and histopathological examination.…”

Section: Bacopa Monnieri Toxicity Spectrum and Herb-drug Interactionsmentioning

confidence: 99%

In Quest of the Mysterious Holistic Vedic Herb Bacopa monnieri (L.) Pennell

Mondal¹,

Bhar²,

Mondal³

et al. 2023

Pharmacogn. Res.

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Throughout history, complementary and alternative therapies have been widely utilised. In recent years, there has been a surge in interest in the usage of herbal treatments all around the world. Various natural chemicals, such as those produced from plants, have been investigated as potential therapies for a myriad of ailments. The essence of this review was to methodically describe everything we know about Bacopa monnieri (L.) Pennell, a mysterious holistic Vedic herb belonging to the Plantaginaceae family, a well-known nootropic and effective memory enhancer, which has recently emerged as one of the most important medical herbs, widely used therapeutically in the Orient and growing in popularity around the world. Literature was gathered from sources such as Scopus, PubMed, Google Scholar, and ScienceDirect, and reviewed using the Prisma quality metacritic paradigm. It is now plainly obvious that current therapies fall short of meeting the demands of the vast majority of individuals with health problems, and traditional medicines are gaining appeal as a result of their reduced toxicity. Bacopa is a traditional herb used in Ayurvedic medicine to treat brain and nerve weariness, as well as in Siddha medicine to treat impaired memory. It's also used to cure brain and nerve exhaustion in Unani medicine. We improved Brahmi micropropagation and secondary metabolite biosynthesis by compiling pharmacobotanical and pharmacognostical descriptions, as well as ethnoarchaeological data and nanotechnology domination. This critique also highlights our contemporary information of pharmacological activity, preclinical and clinical investigations, significant bioactives, reported mechanisms of action, clinical effectiveness, safety, and the potential for herb-drug interactions. At the same time, the current incarnation of research at the plant is reviewed, as well as future research possibilities. Brahmi offers a lot of potential for treating a range of illnesses, including neuro-pharmacological, depression, inflammation, hepatoprotective, antidiabetic, and others. According to the presumptions of this review, further clinical trials and research are needed. While the impact of Brahmi as an anxiolytic and antidepressant has to be explored further, its potential as an anti-epileptic therapy and a treatment for antiepileptic drugs side effects is also being researched. Furthermore, Brahmi's antioxidant ability may explain, at least in part, the antistress, immunomodulatory, cognition-facilitating, anti-inflammatory, and anti-aging benefits documented in experimental animals and clinical circumstances, necessitating further study into its other therapeutic characteristics.

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Section: Bacopa Monnieri Toxicity Spectrum and Herb-drug Interactionsmentioning

confidence: 99%