2011
DOI: 10.1016/j.ahj.2011.02.010
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Acute and short-term hemodynamic effects of metoprolol in Eisenmenger syndrome: A preliminary observational study

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Cited by 5 publications
(3 citation statements)
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“…No data from RCT are available on the usefulness and safety of specific left-side HF therapies (β-blockers, angiotensin-converting enzyme-inhibitors, angiotensin receptor-neprilysin, sodium-glucose cotransporter-2 in-hibitors) in PAH [8,82,105]. A prospective study suggested that b-blockers therapy (metoprolol) may improve effort tolerance in selected ES patients [8,106]. Left-side HF therapies are not recommended in patients with PAH unless it is required by additional comorbidities (i.e., high blood pressure, coronary artery disease, associated left-side HF, or arrhythmia).…”
Section: Cardiac Drugs In Chd-related Pulmonary Arterial Hypertensionmentioning
confidence: 99%
“…No data from RCT are available on the usefulness and safety of specific left-side HF therapies (β-blockers, angiotensin-converting enzyme-inhibitors, angiotensin receptor-neprilysin, sodium-glucose cotransporter-2 in-hibitors) in PAH [8,82,105]. A prospective study suggested that b-blockers therapy (metoprolol) may improve effort tolerance in selected ES patients [8,106]. Left-side HF therapies are not recommended in patients with PAH unless it is required by additional comorbidities (i.e., high blood pressure, coronary artery disease, associated left-side HF, or arrhythmia).…”
Section: Cardiac Drugs In Chd-related Pulmonary Arterial Hypertensionmentioning
confidence: 99%
“…Another randomized controlled trial with patients who had undergone surgical correction of Tetralogy of Fallot found no effects of bisoprolol treatment on symptoms or haemodynamics, but increases in atrial natriuretic peptide and brain natriuretic peptide levels were observed . More recent single‐arm prospective studies found that β‐blockers improved NYHA functional class, RV ejection fraction and quality of life in patients with transposition of the great arteries, and they increased the 6 min walking distance in patients with Eisenmenger syndrome . However, the lack of comparative placebo groups does limit these studies.…”
Section: β‐Adrenoceptor Blockade In Right Heart Failure Related To Chdmentioning
confidence: 99%
“…49 More recent single-arm prospective studies found that -blockers improved NYHA functional class, RV ejection fraction and quality of life in patients with transposition of the great arteries, 50 and they increased the 6 min walking distance in patients with Eisenmenger syndrome. 51 However, the lack of comparative placebo groups does limit these studies. The contradictory results (in terms of the usefulness of -blocking treatment in RHF induced by CHD) may be explained by the heterogeneity of the patient group (for age and HF aetiology) as well as sample sizes and short follow-up periods.…”
Section: -Adrenoceptor Blockade In Right Heart Failure Related To Chdmentioning
confidence: 99%