Acute and separate modulation of motor and cognitive performance in parkinsonian rats by bilateral stimulation of the subthalamic nucleus

Temel, Yasin; Visser‐Vandewalle, Veerle; Aendekerk, Brenda; Rutten, Bart P. F.; Tan, Sonny; Scholtissen, Bart; Schmitz, Christoph; Blokland, Arjan; Steinbusch, Harry W.M.

doi:10.1016/j.expneurol.2004.12.025

Cited by 100 publications

(62 citation statements)

References 59 publications

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“…To investigate weight variation and nutritional state in PD we used the 6-OHDA rat model with bilateral lesion of the striatum that has been validated as an experimental model of PD [17,26,27]. In this study we also investigated the influence of DBS-STN on the nutritional state of parkinsonian rats.…”

Section: Discussionmentioning

confidence: 99%

“…To investigate the additional effect of DBS in the 6-OHDA striatal rat model of PD a model of electrode implantation and of bilateral high frequency stimulation at the level of the STN was used [17,32,42]. Insertion of the electrodes did not cause any significant changes in the metabolic parameters tested, therefore ruling out any effect on structures others than the ones being targeted by stimulation.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies discuss the non-motor effects of DBS-STN and the mechanism underling DBS-STN appears to be more complex than a simple inactivation of the structure [16][17][18][19]. In recent years, several studies have been performed to try to address this issue, namely experimental studies [20,21].…”

Section: Deep Brain Stimulation Of Subthalamic Nucleus (Dbs-stn) Offersmentioning

confidence: 99%

“…To study weight variation and feeding behavior in PD, we used the rat model of PD with bilateral injection of 6-OHDA into striatum which leads to retrograde degeneration of dopaminergic neurons in substantia nigra and bilateral DBS-STN stimulation [17,32].…”

Section: Deep Brain Stimulation Of Subthalamic Nucleus (Dbs-stn) Offersmentioning

confidence: 99%

“…An experimental group of Parkinsonian animals with 6-OHDA striatal lesion with 4 intrastriatal injections of 6-OHDA (2 per hemisphere) as previously described with DBS-STN stimulation was constituted in order to analyze the effect of striatal lesion and neurostimulation on feeding behavior and weight variation [17,27,32].…”

Section: -Hydroxidopamine Lesion and Electrode Implantationmentioning

confidence: 99%

See 4 more Smart Citations

Evaluation of Metabolic State in Striatal Rat Model of Parkinson’s Disease: before and after Deep Brain Stimulation

Guimarães¹,

Moura²,

Silva³

et al. 2013

J Obes Weight Loss Ther

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Deep Brain Stimulation Of Subthalamic Nucleus (Dbs-stn) Offersmentioning

confidence: 99%

Section: Deep Brain Stimulation Of Subthalamic Nucleus (Dbs-stn) Offersmentioning

confidence: 99%

Section: -Hydroxidopamine Lesion and Electrode Implantationmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of Metabolic State in Striatal Rat Model of Parkinson’s Disease: before and after Deep Brain Stimulation

Guimarães¹,

Moura²,

Silva³

et al. 2013

J Obes Weight Loss Ther

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A gradual increase of iron toward the medial‐inferior tip of the subthalamic nucleus

Hollander

Keuken

Bazin

et al. 2014

Human Brain Mapping

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The subthalamic nucleus (STN) is an important node of the cortico-basal ganglia network and the main target of deep brain stimulation (DBS) in Parkinson's disease. Histological studies have revealed an inhomogeneous iron distribution within the STN, which has been related to putative subdivisions within this nucleus. Here, we investigate the iron distribution in more detail using quantitative susceptibility mapping (QSM), a novel magnetic resonance imaging (MRI) contrast mechanism. QSM allows for detailed assessment of iron content in both in vivo and postmortem tissue. Twelve human participants and 7 postmortem brain samples containing the STN were scanned using ultra-high field 7 Tesla (T) MRI. Iron concentrations were found to be higher in the medial-inferior tip of the STN. Using quantitative methods we show that the increase of iron concentration towards the medial-inferior tip is of a gradual rather than a discrete nature.

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High‐frequency stimulation of the subthalamic nucleus restores neural and behavioral functions during reaction time task in a rat model of Parkinson's disease

Wang

Gao

et al. 2009

J of Neuroscience Research

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Deep brain stimulation (DBS) has been used in the clinic to treat Parkinson’s disease (PD) and other neuropsychiatric disorders. Our previous work has shown that DBS in the subthalamic nucleus (STN) can improve major motor deficits, and induce a variety of neural responses in rats with unilateral dopamine (DA) lesions. In the present study, we examined the effect of STN DBS on reaction time (RT) performance and parallel changes in neural activity in the cortico-basal ganglia regions of partially bilateral DA- lesioned rats. We recorded neural activity with a multiple-channel single-unit electrode system in the primary motor cortex (MI), the STN, and the substantia nigra pars reticulata (SNr) during RT test. RT performance was severely impaired following bilateral injection of 6-OHDA into the dorsolateral part of the striatum. In parallel with such behavioral impairments, the number of responsive neurons to different behavioral events was remarkably decreased after DA lesion. Bilateral STN DBS improved RT performance in 6-OHDA lesioned rats, and restored operational behavior-related neural responses in cortico-basal ganglia regions. These behavioral and electrophysiological effects of DBS lasted nearly an hour after DBS termination. These results demonstrate that a partial DA lesion-induced impairment of RT performance is associated with changes in neural activity in the cortico-basal ganglia circuit. Furthermore, STN DBS can reverse changes in behavior and neural activity caused by partial DA depletion. The observed long-lasting beneficial effect of STN DBS suggests the involvement of the mechanism of neural plasticity in modulating corticobasal ganglia circuits.

show abstract

Acute and separate modulation of motor and cognitive performance in parkinsonian rats by bilateral stimulation of the subthalamic nucleus

Cited by 100 publications

References 59 publications

Evaluation of Metabolic State in Striatal Rat Model of Parkinson’s Disease: before and after Deep Brain Stimulation

Evaluation of Metabolic State in Striatal Rat Model of Parkinson’s Disease: before and after Deep Brain Stimulation

A gradual increase of iron toward the medial‐inferior tip of the subthalamic nucleus

High‐frequency stimulation of the subthalamic nucleus restores neural and behavioral functions during reaction time task in a rat model of Parkinson's disease

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