Acute and long-term genotoxicity of deltamethrin to insulin-like growth factors and growth hormone in rainbow trout

Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity

“…However, it is critically important to explore further classes of potent CAIs in order to detect compounds with a different inhibition profiles as compared to the sulfonamides and their bioisosteres and to find novel applications for the inhibitors of these widespread enzymes, in particular tumor-related isoforms. Studies regarding interactions of different proteins and enzymes are of particular interest for toxicologists and medicinal chemists [41][42][43][44][45][46][47][48] and many such investigations exist in the literature [49][50][51][52][53][54][55] . The discovery of novel inhibitors of CAs has also gained great attention in the recent years.…”

Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI

“…The interactions between specific enzymes and various types of inhibitors are of great importance and corresponding investigations have become very popular in the recent years. These substances are sometimes useful in medicinal applications, whereas they have undesirable effects on both human metabolism and other organisms [9][10][11][12][13][14][15][16][17][18][19][20][21] . Carbonic anhydrase inhibitors or activators have several medical applications, such as in the treatment of glaucoma, as diuretics, in the management of several neurological disorders, including epilepsy, possibly in the treatment of Alzheimer's disease, whereas several agents are in clinical evaluations as antiobesity or antitumor drugs/diagnostic tools [3][4][5][6][7] .…”

Heavy metal ion inhibition studies of human, sheep and fish α-carbonic anhydrases

“…Most metal ions are toxic to humans, animals, plants and other living organisms. Because of bioaccumulation, man and other organisms are at great risk of health hazards associated with toxic metals [13][14][15][16][17][18][19][20][21][22] . Several studies shown that people in different regions of the world are being exposed to…”