Acute and late side-effects after low dose-rate brachytherapy for prostate cancer; incidence, management and technical considerations

Helou, Joelle; Charas, Tomer

doi:10.1016/j.brachy.2021.03.014

Cited by 8 publications

(10 citation statements)

References 92 publications

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“…Beside the enormous direct cost to the healthcare system, cancer diagnosis and treatment often have long-term health and financial costs for patients and their families. Complex late effects, both physical (e.g., fatigue, pulmonary, cognitive, neurological, secondary cancer, sexual and cardiac effects,) and psychosocial (e.g., anxiety, depression, fear of recurrence), require ongoing medical care and can substantially affect the quality of life of cancer survivors [ 8 , 9 , 10 , 11 , 12 ]. The indirect burden of cancer spans indirect economic costs, such as productivity losses, carer time, and reduced household income, as well as intangible costs that cannot be measured in monetary terms, such as disruption to family life and involuntary lifestyle changes [ 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Cancer Survivors’ Long-Term Health Service Costs in Queensland, Australia: Results of a Population-Level Data Linkage Study (Cos-Q)

Merollini

Gordon

et al. 2022

IJERPH

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Worldwide, the number of cancer survivors is rapidly increasing. The aim of this study was to quantify long-term health service costs of cancer survivorship on a population level. The study cohort comprised residents of Queensland, Australia, diagnosed with a first primary malignancy between 1997 and 2015. Administrative databases were linked with cancer registry records to capture all health service utilization. Health service costs between 2013–2016 were analyzed using a bottom-up costing approach. The cumulative mean annual healthcare expenditure (2013–2016) for the cohort of N = 230,380 individuals was AU$3.66 billion. The highest costs were incurred by patients with a history of prostate (AU$538 m), breast (AU$496 m) or colorectal (AU$476 m) cancers. Costs by time since diagnosis were typically highest in the first year after diagnosis and decreased over time. Overall mean annual healthcare costs per person (2013–2016) were AU$15,889 (SD: AU$25,065) and highest costs per individual were for myeloma (AU$45,951), brain (AU$30,264) or liver cancer (AU$29,619) patients. Our results inform policy makers in Australia of the long-term health service costs of cancer survivors, provide data for economic evaluations and reinforce the benefits of investing in cancer prevention.

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Section: Introductionmentioning

confidence: 99%

Cancer Survivors’ Long-Term Health Service Costs in Queensland, Australia: Results of a Population-Level Data Linkage Study (Cos-Q)

Merollini

Gordon

et al. 2022

IJERPH

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“…We have also experienced ischemic enterocolitis after LDR‐B, and defecation as well as urination control is important 14 . Dysuria and hematuria in LDR‐B are reported in 7%–13% and 0%–14% of cases, respectively 13 . Furthermore, within the first postoperative years, dysuria often occurs within 1–2 months, and hematuria is relatively rare, occurring in 0.2% of cases 10 .…”

Section: Discussionmentioning

confidence: 94%

A seed link connector protruding into the bladder formed a bladder stone

Aoyama,

Izumi,

Makino

et al. 2024

IJU Case Reports

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IntroductionLow‐dose‐rate brachytherapy is performed for localized prostate cancer. We report the first case of a bladder stone encompassing the seed migrated into the bladder in a patient treated with low‐dose‐rate brachytherapy.Case presentationA man was diagnosed with prostate cancer and underwent low‐dose‐rate brachytherapy. After 2 months, dysuria occurred, and ultrasonography revealed a needle‐shaped high‐intensity protruding from the prostate into the bladder. Cystoscopy examination found a seed link connector. With the possibility of natural dissolution of the seed link, careful observation was chosen. However, 16 months later, hematuria occurred, and an X‐ray revealed a bladder stone encompassing the seed. Compared with the X‐ray right after seeding, the seed located near the right bladder neck had fallen. The seed was removed by transurethral bladder lithotripsy.ConclusionSeeds should be carefully located within the prostate, otherwise a bladder stone may be formed encompassing the seed.

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“…For example, radiation therapy may cause urinary retention due to radiation-induced inflammation and scarring of the lower urinary tract, while radical prostatectomy may lead to urinary incontinence. 26,27 These consequences of prostate cancer may thus have contributed to the increased use of catheters in older men.…”

Section: Discussionmentioning

confidence: 99%

Regional variation in urinary catheter use in the Netherlands from 2012 to 2021: a population-based cohort

van Veen,

Scheepe,

Blok

2023

Therapeutic Advances in Urology

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Objectives: Our aim was to evaluate trends and regional differences in the use of indwelling and intermittent urinary catheters in the community setting in the Netherlands from 2012 to 2021. Design and methods: For this population-based cohort study, data on catheter use was collected from the Drug and Medical Devices Information System of the National Healthcare Institute of the Netherlands. This database contains information on the Dutch insured population, which was 100% of the total population in 2018. Users were divided into 12 provinces according to the Nomenclature of Territorial Units for Statistics codes. The number of catheter users was adjusted for the total population of the provinces by sex and age, and was expressed by users per 100,000 people. Negative binomial regression (NBR) was used to test for differences in clean intermittent catheter (CIC) and indwelling catheter (IDC) users across Dutch provinces. Results: Between 2012 and 2021, IDC users increased by 44.6% from 41,619 to 60,172, and CIC users increased by 27.3% from 34,204 to 43,528. The greatest increases were mainly observed among IDC users over 85 years old and male CIC users over 65 years old. NBR showed significant differences for IDC and CIC users between the 12 provinces. CIC incidence was higher in Drenthe and Groningen (Northern Netherlands) compared to Zuid-Holland (Southern Netherlands). IDC incidence was higher in seven provinces dispersed throughout the Netherlands compared to Noord-Holland. Conclusion: CIC and IDC users have continued to increase in recent years; this was especially observed among older men. In addition, there were regional differences in the number of CIC and IDC users; CIC was more prominent in the northern region of the Netherlands, and IDC varied between multiple provinces. Practice variation in urinary catheterization may result from patient population differences or healthcare provider preferences and their alignment with guidelines.

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Acute and late side-effects after low dose-rate brachytherapy for prostate cancer; incidence, management and technical considerations

Cited by 8 publications

References 92 publications

Cancer Survivors’ Long-Term Health Service Costs in Queensland, Australia: Results of a Population-Level Data Linkage Study (Cos-Q)

Cancer Survivors’ Long-Term Health Service Costs in Queensland, Australia: Results of a Population-Level Data Linkage Study (Cos-Q)

A seed link connector protruding into the bladder formed a bladder stone

Regional variation in urinary catheter use in the Netherlands from 2012 to 2021: a population-based cohort

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