Acute and Late Genitourinary Toxicity after 72 Gy of Conventionally Fractionated Conformal Radiotherapy for Localised Prostate Cancer: Impact of Individual and Clinical Parameters

Stanković, Vesna; Džamić, Zoran; Pekmezović, Tatjana; Tepavčević, Darija Kisić; Dožić, Marko; Sarić, Milan; Vučković, Sandra; Nikitović, Marina

doi:10.1016/j.clon.2016.04.041

Cited by 24 publications

(22 citation statements)

References 43 publications

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“…Results from a multivariate analysis conducted by Stankovic et al [42] revealed current smoking to be a significant prognostic factor for acute genitourinary toxicity of any grade (P ¼ .036) and grades 2 (P ¼ .003). The authors estimated that current smokers were at 17 times an increased risk of developing an acute genitourinary toxicity from radiation than former and nonsmokers (P ¼ .003).…”

Section: Treatment-related Outcomesmentioning

confidence: 98%

“…PC may be treated with prostatectomy, radiation including brachytherapy or external beam radiation treatment, chemotherapy and/or hormonal treatment. Current smoking has been associated with enhanced side effects from several of these treatments, which include genitourinary and gastrointestinal symptoms [15,19,21,[41][42][43].…”

Section: Treatment-related Outcomesmentioning

confidence: 99%

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Adverse Health Outcomes Associated with Postdiagnosis Smoking in Prostate Cancer Patients: A Literature Review

Ganesh

Zaki

Chan

et al. 2017

Journal of Medical Imaging and Radiation Sciences

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Section: Treatment-related Outcomesmentioning

confidence: 98%

Section: Treatment-related Outcomesmentioning

confidence: 99%

Adverse Health Outcomes Associated with Postdiagnosis Smoking in Prostate Cancer Patients: A Literature Review

Ganesh

Zaki

Chan

et al. 2017

Journal of Medical Imaging and Radiation Sciences

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“…Smoking, previous abdominopelvic surgeries and the use of diuretics significantly affect the occurrence of acute genitourinary toxicity grade ≥ 2. Risk factors for the development of late genitourinary complications (i.e., cystitis, hematuria, urethral stricture, or bladder contracture) are higher radiation dose, previous urinary problems, transurethral interventions, and acute genitourinary complications [15,17].…”

Section: Volumetric Modulated Arc Therapymentioning

confidence: 99%

Modern radiotherapy in the treatment of localized prostate cancer

2021

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Prostate cancer (PC) is one of the most prevalent cancers in men and the second leading cause of cancerrelated deaths, after lung cancer. The incidence and mortality from PC worldwide are correlated with increasing age. The treatment of patients is multidisciplinary, with radiotherapy being an integral part, whether applied as an independent method or in combination with surgery or systemic therapy. The technological progress in the middle of the last century, opened up new possibilities in the planning and conducting radiotherapy started the new era of radiotherapy called modern radiotherapy. Today, highly conformal external beam techniques such as intensity-modulated radiotherapy (IMRT) and volume-modulated arc therapy (VMAT) are used as the gold standard in PC radiotherapy. They enable the precise definition of tumor volume based on modern diagnostic procedures, with maximum sparing of the surrounding organs. Advanced conformal techniques have also led to an escalation of the tumor dose, thus achieving better local control of the disease with significant reduction of early and late complications of treatment, the quality of life of PC patients is preserved. In addition to technological progress, modern radiotherapy includes monitoring the side effects of radiotherapy, and assessment of clinical and individual parameters that affect sensitivity and response to radiation. This should enable personalized radiotherapy with optimization of the treatment for each patient, which is one of the goals of modern oncology.

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“…The importance of dose escalation for tumor control in the management of localized prostate cancer after External beam radiotherapy (EBRT) as a definitive treatment has been shown in numerous trials where by increasing the radiation dose then the developing complications caused by injury to organs at risk (bladder, prostatic urethra and rectum) also increase [5].…”

Section: Introductionmentioning

confidence: 99%

Influence of Dosimetric Considerations in Evaluating Second Cancer Risks in Prostate Cancer

Elgendy¹,

Attia²,

Attalla³

et al. 2018

IJMPCERO

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Influence of dosimetric considerations in evaluating second cancer risks in prostate cancer. Material and methods: Fifteen patients in this study suffering from early stage of prostate cancer, each patient underwent three plans: 1) Three-dimensional conformal radiation therapy (3DCRT), 2) Rotation therapy (Arc therapy), and 3) intensity-modulated radiation therapy (IMRT) plan. Estimate secondary metastasis risk models: Excess Relative Risk (ERR) and Excess absolute risk (EAR) based on age of exposure by taking dosimetry data from Dose Volume Histograms (DVHs) to calculate risk models. Result: The second cancer risk models (ERR and EAR) for organs at risk OARs decrease with increasing age of exposure for 3D-CRT, ARC and IMRT and there is no significant difference for ERR and EAR model for developing second cancer risk in 3D-CRT, ARC and IMRT.

show abstract

Acute and Late Genitourinary Toxicity after 72 Gy of Conventionally Fractionated Conformal Radiotherapy for Localised Prostate Cancer: Impact of Individual and Clinical Parameters

Cited by 24 publications

References 43 publications

Adverse Health Outcomes Associated with Postdiagnosis Smoking in Prostate Cancer Patients: A Literature Review

Adverse Health Outcomes Associated with Postdiagnosis Smoking in Prostate Cancer Patients: A Literature Review

Modern radiotherapy in the treatment of localized prostate cancer

Influence of Dosimetric Considerations in Evaluating Second Cancer Risks in Prostate Cancer

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