Acute and fulminant hepatitis induced by flutamide: Case series report and review of the literature

Brahm, Javier; Brahm, Magdalena; Segovia, Roberto; Latorre, R; Zapata, Rodrigo; Poníachik, Jaime; Buckel, E.; Contreras, Luis

doi:10.1016/s1665-2681(19)31595-9

Cited by 49 publications

(3 citation statements)

References 26 publications

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“… 55 This is concerning as PCOS is already a condition with intrinsic metabolic and lipid abnormalities, which could be further exacerbated by bicalutamide therapy. Flutamide has also been associated with hepatotoxicity, 56 which was reflected in this systematic review where three women dropped out from the study by Falsetti et al. 30 due to flutamide-induced hepatotoxicity.…”

Section: Discussionmentioning

confidence: 92%

Efficacy and safety of anti-androgens in the management of polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials

et al. 2023

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Section: Discussionmentioning

confidence: 92%

Efficacy and safety of anti-androgens in the management of polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials

et al. 2023

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“…Spironolactone is often preferred due to its anti-inflammatory effects and ability to counteract adverse side effects of OCP. However, the use of antiandrogens is limited due to their potential major side effects, which must be carefully considered before prescribing these drugs to patients [44][45][46]. Metformin is widely used since it improves insulin sensitivity, restores ovarian function, improving the metabolic and hormonal profile [42].…”

Section: The Management Of Hyperandrogenism In Polycystic Ovary Syndromementioning

confidence: 99%

The role of berberine in polycystic ovary syndrome — a summary of knowledge

Jurgiel,

Graniak,

Opyd

et al. 2024

Ginekol Pol

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Polycystic ovary syndrome (PCOS) is a widely prevalent condition that affects approximately 5-10% of women of reproductive age. Although first described in the 18 th century, a detailed account of the disease was not provided until Stein and Leventhal's 1935 report. Due to the varied symptomatology of PCOS, treatment must be tailored and often involves using multiple drugs for optimal pharmacotherapy. Berberine, an alkaloid with a longstanding history of use, has gained popularity as a potential treatment option for PCOS. Previous studies have demonstrated that berberine can improve hormonal imbalances by reducing testosterone and FAI, increasing SHBG, and mitigating the clinical symptoms of androgen excess, including hirsutism and acne. Moreover, berberine enhances the therapeutic effects of other drugs commonly used in PCOS, such as metformin and oral contraceptive pills. It is generally well-tolerated with a favourable safety profile. However, further research is warranted to establish conclusive evidence regarding berberine's mechanistic underpinnings, therapeutic potential, and long-term safety as a PCOS treatment modality.

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“…1 2 Flutamide exerts its anti-androgenic effect by inhibiting androgen uptake and preventing androgen binding. 3 Although drug-induced haemolytic anaemia is rare, it can be fatal. 4 5 Immunemediated destruction of red blood cells (RBCs) is the predominant cause of drug-induced haemolytic anaemia.…”

Section: Introductionmentioning

confidence: 99%

Haemolytic anaemia induced by flutamide: a case report

Sun

Zhu

et al. 2021

Eur J Hosp Pharm

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Flutamide-induced haemolytic anaemia is rare but can be fatal. We describe the case of an 88-year-old man with prostatic carcinoma who, in addition to clinically obvious jaundice, developed haemolytic anaemia after undergoing treatment with flutamide for 5 days. When flutamide was replaced with temporary adrenocortical hormone treatment and blood transfusion, the blood indices and liver function of the patient improved gradually. We emphasise the need for routine monitoring of blood counts for patients undergoing flutamide treatment, and highlight the importance of discontinuing flutamide immediately when haemolytic anaemia occurs.

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Acute and fulminant hepatitis induced by flutamide: Case series report and review of the literature

Cited by 49 publications

References 26 publications

Efficacy and safety of anti-androgens in the management of polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials

Efficacy and safety of anti-androgens in the management of polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials

The role of berberine in polycystic ovary syndrome — a summary of knowledge

Haemolytic anaemia induced by flutamide: a case report

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