Acute and delayed intracranial hemorrhage in head-injured patients on warfarin versus direct oral anticoagulant therapy

Hughes, Patrick G.; Alter, Scott M.; Greaves, Spencer W.; Mazer, Benjamin A; Solano, Joshua J.; Shih, Richard D.; Clayton, Lisa M; Trinh, Nhat Q; Lottenberg, Lawrence; Hughes, Mary J.

doi:10.4103/jets.jets_139_20

Cited by 3 publications

(1 citation statement)

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“…[ 19 , 20 ] Hughes et al . [ 21 ] reported a lower incidence of delayed tICH with the use of warfarin as compared to direct oral anticoagulants. In a meta-analysis of eleven studies, it was found that the use of warfarin increased the mortality risk from blunt trauma head by 2 times, [ 22 ] while in another study, it was found that the use of antiplatelet agents increased the risk of progression of tICH by 2 times and is an independent risk factor for increased morbidity and vegetative states.…”

Section: Discussionmentioning

confidence: 99%

Analysis of traumatic intracranial hemorrhage and delayed traumatic intracranial hemorrhage in patients with isolated head injury on anticoagulation and antiplatelet therapy

Raymond

Sterling

Roberts

et al. 2023

JNRP

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Objectives: Anticoagulants and antiplatelet (ACAP) agents are increasingly and frequently used, especially in the elderly. The present study was carried out to assess the prevalence of delayed traumatic intracranial hemorrhage (dtICH) after a normal result on an initial head computed tomography (CT) in adults who were taking ACAP medication. Materials and Methods: The present retrospective included all adult patients who arrived in the emergency department between January 2017 and January 2021 with a history of fall from the patient’s own height, while being on ACAP medication with an isolated head injury. The Institutional Review Board approved the study with a waiver of consent. The primary outcome measures were prevalence of dtICH in patients who had initial normal CT scan brain and were on ACAP medication. Results: There were 2137 patients on ACAP medication, of which 1062 were male, and 1075 were of the female gender. The mean age of the patients was 82.1 years. About 8.2% had positive first CT scans (176/2137), while 0.023 (27/1149) had dtICH. The most common positive finding on the CT scan was subarachnoid hemorrhage followed by subdural hemorrhage. Male gender positively correlated with increased risk for first CT being positive (P = 0.033). Patient’s with comorbidity of cirrhosis and chemotherapy had higher risk of dtICH (P = 0.47, 0.011). Conclusion: There was a very low (0.023%) prevalence of dtICH. Dual therapy or Coumadin therapy made up the majority of tICH. Cirrhosis and chemotherapy were associated with the risk of a repeat CT scan being positive with an initial CT scan negative.

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