Acute and chronic toxicity studies of hydromethanol leaf extract of Helianthus annuus Linn. in rats

Onoja, Samuel O.; Udem, Samuel Chukwuneke; Anaga, Aruh O.; Asuzu, Isaac Uzoma

doi:10.4103/1995-7645.242311

Cited by 9 publications

(9 citation statements)

References 3 publications

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“…More than two thousand species of medicinal plants have been scientifically recorded as herbal medicines for diabetes. These agents have been widely acknowledged to be safe with minimum side effects, efficacious, and affordable (22)(23)(24). This study investigated antihyperglycemic and haematological activities of S. lehmbachii ethanol leaf extract in alloxan-induced hyperglycemic rats for 21 days.…”

Section: Discussionmentioning

confidence: 99%

Antihyperglycaemic and haematological effects of ethanol extract of Salacia lehmbachii leaf in alloxan-induced diabetic Wistar rats

Akuodor

Udia

Ohadoma

et al. 2021

J Herbmed Pharmacol

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Introduction: Salacia lehmbachii is used traditionally for the treatment of diabetes mellitus. This study investigated the hypoglycaemic potentials of ethanol leaf extract of S. lehmbachii and its effects on alloxan-induced diabetic rats’ haematological parameters. Methods: A total of 36 male Wistar rats including normal, diabetic untreated, and diabetic treated ones were used in this study. Diabetes was induced by a single intraperitoneal injection of 150 mg/kg of alloxan. When confirmed diabetes, the rats were orally administered 100 mg/kg, 200 mg/kg, and 400 mg/kg daily of the leaf extract for 21 days. The blood glucose levels and haematological parameters were determined in diabetic treated rats compared with the controls. Results: The ethanol leaf extract of S. lehmbachii significantly reduced the blood glucose levels of alloxan-induced diabetic rats when compared with the diabetic control (P < 0.01). The extract also significantly (P < 0.01) improved the haematological parameters of treated rats at three doses employed. Conclusion: It can be concluded that the ethanol leaf extract of S. lehmbachii possesses antihyperglycaemic properties and could be considered a potential candidate for the development of new drugs in the treatment of anaemic conditions.

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Section: Discussionmentioning

confidence: 99%

Antihyperglycaemic and haematological effects of ethanol extract of Salacia lehmbachii leaf in alloxan-induced diabetic Wistar rats

Akuodor

Udia

Ohadoma

et al. 2021

J Herbmed Pharmacol

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“…Hepatocellular damage and functional capacity of the liver are evaluated by determining some enzymes and proteins in Table 4. The functional capacity of the kidney was evaluated via the determination of the serum urea and creatinine levels 1 . Clinical biochemistry tests are used in toxicology studies to generate data that are crucial for evaluating altered organ function or major toxic effects in tissues in experimental animals 33 .…”

Section: Discussionmentioning

confidence: 99%

“…Plant-derived medicines have been known as unique sources for delivering many bioactive lead compounds for the development of new medicines and also for the treatment and prevention of various ailments of the human body and are easily accessed, an affordable, efficacious and culturally acceptable form of drug 1 . Unani system of medicine advocates therapeutic uses of herbal, mineral, and metallic preparations in many diseases since century in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

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2020

IJPSR

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“…There is a growing interest in the use of herbal preparations in the management of disease conditions. About 80% of the world populace have used herbal preparation either as a supplement or a therapeutic agent (Ezuruike and Prieto, 2014;Onoja et al, 2018). Herbal preparations are perceived to be devoid of side effects, but this is not true especially when used for a prolonged time (Kunle et al, 2012;Ezeja et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Acute and sub-acute toxicity profile of methanol extract of Hura crepitans leaf on Wistar rats

et al. 2021

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This study investigated the toxicity profile of methanol extract of Hura crepitans leaf on albino rats. The up-and-down method at a dose limit of 2000 mg/kg was used in the oral acute toxicity test. Twenty-four (24) albino Wistar rats were randomly assigned to 4 groups (A –D, n = 6). Group A (control) received distilled water, while groups B-D received 100, 200 and 400 mg/kg of the extract, respectively. The rats were dosed once daily for 21 consecutive days and weighed weekly. Twenty-four hours after the last treatment on day 21, the rats were fasted overnight and blood was collected into EDTA and plain bottles for hematological evaluation and serum preparation respectively. A manual method was used to determine the full blood cell count, while Randox kit was used to estimate the serum markers of liver and kidney functions. The extract was tolerated by the rat; the LD50 was greater than 2000 mg/kg. At 21 days of treatment, the extract (100, 200 and 400 mg/kg) treated groups had 27.53, 25.98 and 25.33% weight gain respectively, while the distilled water treated group had 8.38% weight gain. The extract (200 and 400 mg/kg) reduced (p < 0.05) the packed cell volume, hemoglobin concentration and red cell count, serum aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase activities, but increased the total white blood cell in the treated groups when compared with the control group. This study suggests that methanol extract of Hura crepitans has hepatoprotective activity, promotes weight gain and could precipitate anemia when taken for a long period.

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Acute and chronic toxicity studies of hydromethanol leaf extract of Helianthus annuus Linn. in rats

Cited by 9 publications

References 3 publications

Antihyperglycaemic and haematological effects of ethanol extract of Salacia lehmbachii leaf in alloxan-induced diabetic Wistar rats

Antihyperglycaemic and haematological effects of ethanol extract of Salacia lehmbachii leaf in alloxan-induced diabetic Wistar rats

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Acute and sub-acute toxicity profile of methanol extract of Hura crepitans leaf on Wistar rats

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