Acute and chronic toxicity of 2,4-D and fipronil formulations (individually and in mixture) to the Neotropical cladoceran Ceriodaphnia silvestrii

Silva, Laís C.M.; Moreira, Raquel Aparecida; Pinto, Thandy Junio da Silva; Ogura, Allan Pretti; Yoshii, Maria Paula Cardoso; Lopes, Laís F. P.; Montagner, Cassiana Carolina; Goulart, Bianca Veloso; Daam, Michiel A.; Espíndola, Evaldo Luiz Gaeta

doi:10.1007/s10646-020-02275-4

Cited by 41 publications

(15 citation statements)

References 74 publications

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“…Atualmente ele representa 10% do mercado global de fitossanitários (Kim et al, 2019;Chang & Tsai, 2020). No estado de São Paulo o fipronil e o herbicida 2,4-D são os compostos químicos mais utilizados nas lavouras (Silva et al, 2020). A rápida e expoente adoção desse composto químico foi devido à resistência que insetos-pragas haviam adquirido as outras classes de agroquímicos disponíveis no mercado até então (organofosforados, carbamatos e piretróides), além de suas vantagens físico-químicas, quando em comparação a outros agrotóxicos, que viabilizou a sua utilização sob diferentes formas de aplicação (Leemans et al, 2019;Li et al, 2020).…”

Section: • Fipronilunclassified

“…Entre os organismos afetados pela utilização do fipronil no ambiente temos os insetos polinizadores. Nesses animais o fipronil bloqueia os canais de cloro presentes no receptor GABA (ácido γ-aminobutírico), causando seu acúmulo nas junções sinápticas e a interrupção da transmissão neural do organismo, levando a uma hiperexcitação nervosa e a morte (Liang et al, 2019;Silva et al, 2020;Li et al, 2020). No caso dos vertebrados, os efeitos imediatos do contato com os fitossanitários são menos evidentes devido a reduzida afinidade aos receptores neuronais desses animais (Zhang et al, 2018), o que favorece ainda mais a sua utilização em larga escala.…”

Section: • Fipronilunclassified

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Fitossanitários e doenças hepáticas: Um desafio à saúde pública no Brasil

Molica

Barreto

Moraes

2021

RSD

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A saúde pública de uma população depende de seus costumes, de sua genética e do meio ambiente em que se insere. No Brasil, a política econômica dependente do agronegócio estimula a utilização de fitossanitários e/ou defensivos agrícolas, o que pode ser negativo ao equilíbrio de ecossistemas e à saúde de sua população. Esses compostos químicos tiveram seu uso difundido na chamada Revolução Verde na década de 1960. No território brasileiro vários defensivos agrícolas são vendidos que, além do controle de pragas agrícolas, causam danos ao meio ambiente e a organismos não-alvo. Considerando-se as anomalias que acometem a saúde da população, as doenças hepáticas podem ser causadas pelo uso indiscriminado de fitossanitários. Caracterizadas pela Organização Mundial da Saúde como uma das 10 causas primárias de morte em diferentes países, essas anomalias possuem várias etiologias entre as quais a exposição a drogas e a toxinas ambientais. Uma vez estabelecido o quadro clínico das anomalias hepáticas, estas podem progredir a quadros mais deletérios e até mesmo conduzir os indivíduos ao óbito. Embora muito estudada, tratamentos realmente eficazes no controle e/ou cura das doenças hepáticas se embasam na alteração do estilo de vida, como a redução da exposição a compostos químicos. Nesse contexto, a atenção às políticas públicas e aos hábitos populacionais na utilização dos fitossanitários pode ser considerada uma importante aliada no controle e/ou prevenção do surgimento de doenças hepáticas. No presente estudo, abordaremos aspectos gerais sobre os fitossanitários mais utilizados no Brasil, assim como seus efeitos adversos à saúde hepática da população.

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Section: • Fipronilunclassified

Fitossanitários e doenças hepáticas: Um desafio à saúde pública no Brasil

Molica

Barreto

Moraes

2021

RSD

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“…Tests were performed at the following nominal concentrations: 5 µg a.i./L for fipronil and 500 µg a.i./L for 2,4-D prepared from a stock solution of 3.2 mg a.i./L and 1 g a.i./L, respectively. The concentrations of tested pesticides were chosen taking into account the ecological relevance of their environmental occurrence, after reviewing the literature for concentrations reported in surface waters and also based on the results of acute and chronic toxicity tests performed with these compounds to obtain dose-response curves for C. silvestrii (Silva et al 2020). Tests were performed in a semistatic manner, using treatment solutions that were renewed every 2 days.…”

Section: Chronic Toxicitymentioning

confidence: 99%

“…To compare the sensitivity of the cladoceran species, used as the test organism to the fipronil pesticide with that of other species of invertebrates and vertebrates and also its sensitivity to the herbicide 2,4-D with that of primary producers and also invertebrates and vertebrates, species sensitivity distribution curves (SSD) were built using the NOEC (no observed effect concentration) values of the reproduction tests with C. silvestrii previously obtained in the study by Silva et al (2020) with the corresponding values for other species. Data used in the comparison were extracted mainly from the USEPA ECOTOX database (http://cfpub .epa.gov/ ecoto x/) and complemented with data from literature for phytoplankton, macrophytes, invertebrates and freshwater vertebrates, especially focusing on parameters for NOEC and EC 10 .…”

Section: Species Sensitivity Distributionsmentioning

confidence: 99%

Life-History Traits Response to Effects of Fish Predation (Kairomones), Fipronil and 2,4-D on Neotropical Cladoceran Ceriodaphnia silvestrii

Moreira

Pinto

Silva

et al. 2020

Arch Environ Contam Toxicol

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Aquatic environments are constantly exposed to a cocktail of contaminants mainly due to human activities. As polluted ecosystems may simultaneously present other multiple natural stressors, the objective of the present study was to evaluate joint effect of stressors (natural and anthropogenic) on life history traits of the Neotropical cladoceran, Ceriodaphnia silvestrii. For this purpose, the effects of water conditioned with predator kairomones (fish) and environmental concentrations (sublethal) of two pesticides widely used in sugarcane monoculture in Brazil, the insecticide Regent ® 800 WG (active ingredient-a.i. fipronil) and the herbicide DMA ® 806 BR (a.i. 2,4-D) were evaluated using chronic toxicity testing, isolated and in mixture, for this cladoceran species. The environmental risks of pesticides for tropical freshwater biota were also estimated from the risk quotient MEC/PNEC. Among the characteristics of the life history of C. silvestrii evaluated after 8 days of exposure, compared with the mean value of control, the age of primiparous females was not affected by any evaluated treatment. However, species average survival decreased in the treatment of kairomones mixed with fipronil (FK) and in the treatment with a mixture of fipronil, 2,4-D, and kairomones (MFKD). The body length of maternal females was shorter than in the control after exposure in treatments with only kairomones (K) and FK. Fecundity of this cladoceran was reduced when exposed to FK and MFKD treatments, and the intrinsic rate of population increase significantly decreased for organisms exposed to treatment with fipronil (F) and to mixtures of fipronil and 2,4-D (MFD), MFDK, and FK. The results indicated that the combination of anthropogenic and natural stressors causes changes in C. silvestrii life history traits, which can contribute to the decline in populations, and our preliminary risk assessment results are a matter of concern regarding biota conservation.

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“…According to their specific mode of action, their toxicity is not so significant on some model organisms (such as bacteria or crustaceans), especially in time-and environmental concentration-dependent toxicity tests [53][54][55]. Recently, there have been growing concerns about the presence of herbicides in drinking water affecting non-target organisms.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Herbicides to Marine Organisms Aliivibrio fischeri and Artemia salina

Vurm

Tajnaiová

Kofroňová

2021

Toxics

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The aim of this work was to determine the toxic effect of the most used herbicides on marine organisms, the bacterium Aliivibrio fischeri, and the crustacean Artemia salina. The effect of these substances was evaluated using a luminescent bacterial test and an ecotoxicity test. The results showed that half maximal inhibitory concentration for A. fischeri is as follows: 15minIC50 (Roundup® Classic Pro) = 236 µg.l−1, 15minIC50 (Kaput® Premium) = 2475 µg.l−1, 15minIC50 (Banvel® 480 S) = 2637 µg.l−1, 15minIC50 (Lontrel 300) = 7596 µg.l−1, 15minIC50 (Finalsan®) = 64 µg.l−1, 15minIC50 (glyphosate) = 7934 µg.l−1, 15minIC50 (dicamba) = 15,937 µg.l−1, 15minIC50 (clopyralid) = 10,417 µg.l−1, 15minIC50 (nonanoic acid) = 16,040 µg.l−1. Median lethal concentrations for A. salina were determined as follows: LC50 (Roundup® Classic Pro) = 18 µg.l−1, LC50 (Kaput® Premium) = 19 µg.l−1, LC50 (Banvel® 480 S) = 2519 µg.l−1, LC50 (Lontrel 300) = 1796 µg.l−1, LC50 (Finalsan®) = 100 µg.l−1, LC50 (glyphosate) = 811 µg.l−1, LC50 (dicamba) = 3705 µg.l−1, LC50 (clopyralid) = 2800 µg.l−1, LC50 (nonanoic acid) = 7493 µg.l−1. These findings indicate the need to monitor the herbicides used for all environmental compartments.

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Acute and chronic toxicity of 2,4-D and fipronil formulations (individually and in mixture) to the Neotropical cladoceran Ceriodaphnia silvestrii

Cited by 41 publications

References 74 publications

Fitossanitários e doenças hepáticas: Um desafio à saúde pública no Brasil

Fitossanitários e doenças hepáticas: Um desafio à saúde pública no Brasil

Life-History Traits Response to Effects of Fish Predation (Kairomones), Fipronil and 2,4-D on Neotropical Cladoceran Ceriodaphnia silvestrii

The Influence of Herbicides to Marine Organisms Aliivibrio fischeri and Artemia salina

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